Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast
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The transporter Ccc1 imports iron into the vacuole, which is the major site of iron storage in fungi and plants. CCC1 mRNA is destabilized under low-iron conditions by the binding of Cth1 and Cth2 to the 3' untranslated region (S. Puig, E. Askeland, and D. J. Thiele, Cell 120:99-110, 2005). Here, we show that the transcription of CCC1 is stimulated by iron through a Yap consensus site in the CCC1 promoter. We identified YAP5 as being the iron-sensitive transcription factor and show that a yap5Delta strain is sensitive to high iron. Green fluorescent protein-tagged Yap5 is localized to the nucleus and occupies the CCC1 promoter independent of the iron concentration. Yap5 contains two cysteine-rich domains, and the mutation of the cysteines to alanines in each of the domains affects the transcription of CCC1 but not DNA binding. The fusion of the Yap5 cysteine-containing domains to a GAL4 DNA binding domain results in iron-sensitive GAL1-lacZ expression. Iron affects the sulfhydryl status of Yap5, which is indicative of the generation of intramolecular disulfide bonds. These results show that Yap5 is an iron-sensing transcription factor and that iron regulates transcriptional activation.
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A mutant lacking Ccc1 appeared in category 1, while its supposed regulator Yap5 seemed to play no role.
“A mutant lacking Ccc1, a transporter with a possible role in vacuolar iron sequestration (26), also appeared in this category, while its supposed regulator Yap5 (27) seemed to play no role (see Dataset S1 in the supplemental material).”
From A novel hybrid iron regulation network combines features from pathogenic and nonpathogenic yeasts (2016) · cites this paper as [27]
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- Authors
- Li, L., Bagley, D., Ward, D. M., & Kaplan, J.
- Affiliations
- University of Utah (US)
- Corresponding author
- Kaplan, Jerry
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-02-01
- Volume
- 28
- Issue
- 4
- Pages
- 1326-1337
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2258748
- OpenAlex
- W2106855898
- Cited by
- 121
- References
- 25
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 12 · 2013: 7 · 2012: 10
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK030534, DK30534, R37DK030534)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- iron imports, transcriptional activation, iron sensing, cysteine-rich domain, disulfide bonds, 3' untranslated region, promoter regulation, Saccharomyces cerevisiae
- MeSH terms
- Epitopes, Cell Nucleus, Cysteine, Iron, Lac Operon, Promoter Regions, Genetic, Protein Binding, RNA, Messenger, Saccharomyces cerevisiae, Vacuoles, Transcriptional Activation, Trans-Activators, Gene Expression Regulation, Fungal, Protein Structure, Tertiary, Genes, Reporter, Protein Transport, Cation Transport Proteins, Saccharomyces cerevisiae Proteins, Basic-Leucine Zipper Transcription Factors
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