Cited by 1,055MicroRNA in disease regulationCancer, Hypoxia, and MetabolismCancer-related molecular mechanisms research

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A MicroRNA Signature of Hypoxia

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Kulshreshtha, Ritu, Ferracin, Manuela, Wojcik, Sylwia E., Garzon, Ramiro, Alder, Hansjuerg, Agosto-Perez, Francisco J., Davuluri, Ramana, Liu, Chang-Gong, Croce, Carlo M., Negrini, Massimo, Calin, George A., Ivan, Mircea·2007·Molecular and Cellular Biology

DOI 10.1128/mcb.01395-06PMC PMC1820461

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Abstract

Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.

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Authors: Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., Calin, G. A., & Ivan, M.
Affiliations: Tufts Medical Center (US)
University of Ferrara (IT)
The Ohio State University (US)
Comprehensive Cancer Center, Ohio State University
Corresponding author: Ivan, Mircea
ORCID: Kulshreshtha, Ritu
Ferracin, Manuela
Wojcik, Sylwia E.
Garzon, Ramiro
Agosto-Perez, Francisco J.
Davuluri, Ramana
Croce, Carlo M.
Negrini, Massimo
Calin, George A.
Ivan, Mircea
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2007-03-01
Volume: 27
Issue: 5
Pages: 1859-1867
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.01395-06
PMC: PMC1820461
OpenAlex: W2116000203
Cited by: 1,055
References: 31
Citations by year: 2026: 11 · 2025: 19 · 2024: 26 · 2023: 32 · 2022: 45 · 2021: 50 · 2020: 43 · 2019: 54 · 2018: 38 · 2017: 70 · 2016: 63 · 2015: 73 · 2014: 91 · 2013: 93 · 2012: 81
FWCI: 16.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-34928, P30DK034928)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, hypoxia, hypoxia-inducible factor, miR-210, miR-26, miR-107, tumor microenvironment, tumor formation, apoptosis, miRNA expression profiling, non-coding RNA regulation
MeSH terms: Breast Neoplasms, Colonic Neoplasms, Female, Humans, Luciferases, Plasmids, Transfection, Cell Hypoxia, Apoptosis, Genes, Reporter, HT29 Cells, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, HCT116 Cells, Cell Line, Tumor, Chromatin Immunoprecipitation

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A MicroRNA Signature of Hypoxia

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