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A MicroRNA Signature of Hypoxia
Open accessAbstract
Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.
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“miR-23a was induced under hypoxic circumstances and can ultimately act upon pro-apoptotic signals to promote tumor formation and oncogenic transformation [89].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [89]
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“Another factor that can induce miR-21 expression is hypoxia, a general feature of all solid tumors (30).”
From MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008) · cites this paper as [30]
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Self-citationJaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“to-alanine substitutions have been described previously (14, 15).”
MethodSelf-citationCombinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Self-citationmiRBase: microRNA sequences, targets and gene nomenclature
Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950
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Huang, L., Ma, Q., Li, Y., Li, B., & Zhang, L. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.024 · Cited by 136
The Genomics and Genetics of Oxygen Homeostasis
Semenza, G. L. (2020) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111119-073356 · Cited by 139
miR-210: Fine-Tuning the Hypoxic Response
Ivan, M., & Huang, X. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_10 · Cited by 137
Self-citationDiagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis
Xin Min, Z. H. O. U., Zhu, W., Li, H., Wen, W. X., Cheng, W., Wang, F., Wu, Y., Qi, L., Fan, Y., Chen, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep11251 · Cited by 135
MicroRNA and Target Protein Patterns Reveal Physiopathological Features of Glioma Subtypes
Lages, E., Guttin, A., El Atifi, M., Ramus, C., Ipas, H., Dupré, I., Rolland, D., Salon, C., Godfraind, C., deFraipont, F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020600 · Cited by 128
Ramalingam, P., Palanichamy, J. K., Singh, A. N., Das, P., Bhagat, M., Kassab, M. A., Sinha, S., & Chattopadhyay, P. (2013) · RNA · doi:10.1261/rna.041814.113 · Cited by 132
Wu, C., So, J., Davis‐Dusenbery, B. N., Qi, H. H., Bloch, D. B., Shi, Y., Lagna, G., & Hata, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05776-11 · Cited by 140
Costales, M. G., Suresh, B. M., Vishnu, K., & Disney, M. D. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.04.008 · Cited by 133
MicroRNA and Colorectal Cancer
Yang, L. G., Belaguli, N. S., & Berger, D. H. (2009) · World Journal of Surgery · doi:10.1007/s00268-008-9865-5 · Cited by 129
The NF-κB member p65 controls glutamine metabolism through miR-23a
Rathore, M. G., Saumet, A., Rossi, J.-F., de Bettignies, C., Tempé, D., Lecellier, C.-H., & Villalba, M. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.011 · Cited by 129
Changes in circulating microRNAs levels with exercise modality
Banzet, S., Chennaoui, M., Girard, O., Racinais, S., Drogou, C., Chalabi, H., & Koulmann, N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2013 · Cited by 129
Colleoni, F., Padmanabhan, N., Yung, H.-W., Watson, E. D., Cetin, I., Tissot van Patot, M. C., Burton, G. J., & Murray, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055194 · Cited by 128
Polytarchou, C., Iliopoulos, D., Hatziapostolou, M., Kottakis, F., Maroulakou, I. G., Struhl, K., & Tsichlis, P. N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0365 · Cited by 132
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells
Babar, I., Czochor, J. R., Steinmetz, A., Weidhaas, J. B., Glazer, P. M., & Slack, F. J. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.10.17681 · Cited by 128
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
Chan, M. C., Holt‐Martyn, J. P., Schofield, C. J., & Ratcliffe, P. J. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.01.001 · Cited by 128
Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2
Wu, N., Zhao, X., Liu, M., Liu, H., Yao, W., Zhang, Y., Cao, S., & Lin, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016264 · Cited by 126
Cell cycle progression in response to oxygen levels
Ortmann, B. M., Druker, J., & Rocha, S. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1645-9 · Cited by 131
Yang, W., Sun, T., Cao, J., Liu, F., Tian, Y., & Zhu, W. J. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.010 · Cited by 122
Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets
Codrici, E., Enciu, A., Popescu, I. D., Mihai, S., & Tănase, C. (2016) · Stem Cells International · doi:10.1155/2016/5728438 · Cited by 125
Kiernan, E. A., Smith, S. M. C., Mitchell, G. S., & Watters, J. J. (2016) · The Journal of Physiology · doi:10.1113/jp271502 · Cited by 125
MicroRNA and Protein Profiling of Brain Metastasis Competent Cell-Derived Exosomes
Camacho, L., Guerrero, P. A., & Marchetti, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073790 · Cited by 123
The tumour hypoxia induced non-coding transcriptome
Choudhry, H., Harris, A. L., & McIntyre, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.01.003 · Cited by 120
Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications
Cai, M., Kolluru, G. K., & Ahmed, A. (2017) · Journal of Pregnancy · doi:10.1155/2017/6972732 · Cited by 120
Chio, C. C., Lin, J., Cheng, H. A., Chiu, W., Wang, Y., Wang, J. J., Hsing, C., & Chen, R. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0965-5 · Cited by 118
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer
Bisso, A., Faleschini, M., Zampa, F., Capaci, V., Santa, J. D., Santarpia, L., Piazza, S., Cappelletti, V., Daidone, M. G., Agami, R., et al. (2013) · Cell Cycle · doi:10.4161/cc.24757 · Cited by 120
Dou, C., Zhou, Z., Xu, Q., Liu, Z., Zeng, Y., Wang, Y., Li, Q., Wang, L., Yang, W., Liu, Q., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0505-8 · Cited by 117
Zachara, N. E., Molina, H., Wong, K. Y., Pandey, A., & Hart, G. W. (2010) · Amino Acids · doi:10.1007/s00726-010-0695-z · Cited by 120
MicroRNAs in adipogenesis and as therapeutic targets for obesity
Alexander, R., Lodish, H. F., & Sun, L. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.561317 · Cited by 118
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Gee, H. E., Ivan, C., Călin, G. A., & Ivan, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5639 · Cited by 119
Self-citationMicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells
Chen, B., Liu, Y., Jin, X., Lu, W., Liu, J., Xia, Z., Yuan, Q., Zhao, X., Xu, N., & Liang, S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-443 · Cited by 117
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Orang, A., Petersen, J., McKinnon, R. A., & Michael, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.014 · Cited by 117
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Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 115
Molecular Pathways: microRNAs, Cancer Cells, and Microenvironment
Berindan‐Neagoe, I., & Călin, G. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2500 · Cited by 114
miR-21 in ischemia/reperfusion injury: a double-edged sword?
Xu, X., Kriegel, A. J., Jiao, X., Liu, H., Bai, X., Olson, J. M. G., Liang, M., & Ding, X. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00020.2014 · Cited by 116
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Luo, R., Shao, X., Xu, P., Liu, Y., Wang, Y., Zhao, Y., Liu, M., Ji, L., Li, Y., Chang, C. K., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03530 · Cited by 114
He, C. H., Wang, L., Zhang, J., & Xu, H. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0603-1 · Cited by 113
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Hypoxia-regulated lncRNAs in cancer
Chang, Y., Zhang, K., Hu, Z., Qi, H.-X., Shi, Z., Han, X., Han, Y., & Wei, H. (2015) · Gene · doi:10.1016/j.gene.2015.08.049 · Cited by 113
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Samadi, A. K., Bilsland, A. E., Georgakilas, A. G., Amedei, A., Amin, A., Bishayee, A., Azmi, A. S., Lokeshwar, B. L., Grue, B., Panis, C., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.006 · Cited by 118
Groenendyk, J., Peng, Z., Dudek, E., Fan, X., Mizianty, M. J., Dufey, E., Urra, H., Sepúlveda, D., Rojas‐Rivera, D., Lim, Y., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004983 · Cited by 112
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Gómez-Maldonado, L., Tiana, M., Roche, O., Prado‐Cabrero, A., Jensen, L. D., Fernández‐Barral, A., Guijarro-Muñoz, I., Favaro, E., Moreno‐Bueno, G., Sanz, L., et al. (2014) · Oncogene · doi:10.1038/onc.2014.200 · Cited by 111
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Wang, Q. Z., Xu, W., Habib, N., & Xu, R. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909788486731 · Cited by 111
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Self-citationRamachandra, R. K., Salem, M., Gahr, S. A., Rexroad, C. E., & Yao, J. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-41 · Cited by 112
Dou, C., Liu, Z., Xu, M. M., Jia, Y., Wang, Y., Li, Q., Yang, W., Zheng, X. M., Tu, K., & Liu, Q. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.011 · Cited by 111
Temporal Differences in MicroRNA Expression Patterns in Astrocytes and Neurons after Ischemic Injury
Ziu, M., Fletcher, L., Rana, S. R., Jimenez, D. F., & Digicaylioglu, M. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014724 · Cited by 107
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Self-citationmiR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma
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Self-citationNakada, C., Tsukamoto, Y., Matsuura, K., Nguyen, T. L., Hijiya, N., Uchida, T., Sato, F., Mimata, H., Seto, M., & Moriyama, M. (2011) · The Journal of Pathology · doi:10.1002/path.2860 · Cited by 108
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Nie, Y., Han, B.-M., Liu, X.-B., Yang, J.-J., Wang, F., Cong, X.-F., & Chen, X. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.762 · Cited by 104
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Self-citationCirculating microRNAs in acute and chronic exercise: more than mere biomarkers
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Lema, C., & Cunningham, M. J. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.06.019 · Cited by 103
Ma, X., Wang, J., Li, J., Ma, C., Chen, S., Lei, W., Yang, Y., Liu, S., Bihl, J. C., & Chen, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488635 · Cited by 103
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Endo, K., Naito, Y., Ji, X., Nakanishi, M., Noguchi, T., Goto, Y., Nonogi, H., Ma, X., Weng, H., Hirokawa, G., et al. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00578 · Cited by 107
Vergani, E., Guardo, L. D., Dugo, M., Rigoletto, S., Tragni, G., Ruggeri, R., Perrone, F., Tamborini, E., Gloghini, A., Arienti, F., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6599 · Cited by 102
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Moncini, S., Salvi, A., Zuccotti, P., Viero, G., Quattrone, A., Barlati, S., De Petro, G., Venturin, M., & Riva, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020038 · Cited by 104
Luo, R., Wang, Y., Xu, P., Cao, G., Zhao, Y., Shao, X., Li, Y.-X., Chang, C., Peng, C., & Wang, Y.-L. (2016) · Scientific Reports · doi:10.1038/srep19588 · Cited by 100
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Liu, Y., Nie, H., Zhang, K., Ma, D., Yang, G., Zheng, Z., Liu, K., Yu, B., Zhai, C., & Yang, S. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.05.067 · Cited by 94
Glorian, V., Maillot, G., Polès, S., Iacovoni, J. S., Favre, G., & Vagner, S. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.35 · Cited by 105
He, M., Wang, Q.-Y., Yin, Q.-Q., Tang, J., Lu, Y., Zhou, C.-X., Duan, C.-W., Hong, D.-L., Tanaka, T. T., Chen, G.-Q., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.130 · Cited by 94
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Self-citationSalzman, D. W., & Weidhaas, J. B. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.016 · Cited by 93
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Raimondi, L., Amodio, N., Martino, M. T. D., Altomare, E., Leotta, M., Caracciolo, D., Gullà, A., Neri, A., Taverna, S., D’Aquila, P., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1747 · Cited by 92
Nagpal, N., Ahmad, H. M., Chameettachal, S., Sundar, D., Ghosh, S., & Kulshreshtha, R. (2015) · Scientific Reports · doi:10.1038/srep09650 · Cited by 94
Self-citationShi, M., & Guo, N. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.12.002 · Cited by 91
Ježek, P., Plecitá‐Hlavatá, L., Smolková, K., & Rossignol, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.008 · Cited by 96
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Toyama, T., Kondo, N., Endo, Y., Sugiura, H., Yoshimoto, N., Iwasa, M., Takahashi, S., Fujii, Y., & Yamashita, H. (2012) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hys001 · Cited by 91
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Zhai, W., Sun, Y., Jiang, M., Wang, M., Gasiewicz, T. A., Zheng, J., & Chang, C. (2016) · Oncogene · doi:10.1038/onc.2016.19 · Cited by 90
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Favaro, E., Lord, S., Harris, A. L., & Buffa, F. M. (2011) · Genome Medicine · doi:10.1186/gm271 · Cited by 91
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Lezina, L., Purmessur, N. S., Antonov, A. V., Ivanova, T., Karpova, E., Kumar, K., Ivan, M., Aksenova, V., Tentler, D., Garabadgiu, A. V., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.483 · Cited by 90
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Vescovo, V. D. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i4.604 · Cited by 88
Gusev, Y. (2007) · Methods · doi:10.1016/j.ymeth.2007.10.005 · Cited by 86
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Rupani, H., Sánchez-Elsner, T., & Howarth, P. H. (2012) · European Respiratory Journal · doi:10.1183/09031936.00212011 · Cited by 87
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Jadhav, V., Hackl, M., Druz, A., Shridhar, S., Chung, C., Heffner, K. M., Kreil, D. P., Betenbaugh, M., Shiloach, J., Barron, N., et al. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.007 · Cited by 94
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Ragusa, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11709 · Cited by 86
MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer
Roscigno, G., Puoti, I., Giordano, I., Donnarumma, E., Russo, V. M., Affinito, A., Adamo, A., Quintavalle, C., Todaro, M., Vivanco, M. D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14470 · Cited by 85
The role of hypoxia inducible factor-1alpha in gynecological cancer
Seeber, L. M. S., Horrée, N., Vooijs, M., Heintz, A. P. M., van der Wall, E., Verheijen, R. H. M., & van Diest, P. J. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.003 · Cited by 85
Metadata
- Authors
- Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., Calin, G. A., & Ivan, M.
- Affiliations
- Tufts Medical Center (US)
- University of Ferrara (IT)
- The Ohio State University (US)
- Comprehensive Cancer Center, Ohio State University
- Corresponding author
- Ivan, Mircea
- ORCID
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-03-01
- Volume
- 27
- Issue
- 5
- Pages
- 1859-1867
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1820461
- OpenAlex
- W2116000203
- Cited by
- 1,055
- References
- 31
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 26 · 2023: 32 · 2022: 45 · 2021: 50 · 2020: 43 · 2019: 54 · 2018: 38 · 2017: 70 · 2016: 63 · 2015: 73 · 2014: 91 · 2013: 93 · 2012: 81
- FWCI
- 16.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-34928, P30DK034928)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, hypoxia, hypoxia-inducible factor, miR-210, miR-26, miR-107, tumor microenvironment, tumor formation, apoptosis, miRNA expression profiling, non-coding RNA regulation
- MeSH terms
- Breast Neoplasms, Colonic Neoplasms, Female, Humans, Luciferases, Plasmids, Transfection, Cell Hypoxia, Apoptosis, Genes, Reporter, HT29 Cells, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, HCT116 Cells, Cell Line, Tumor, Chromatin Immunoprecipitation
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