Cited by 1,055MicroRNA in disease regulationCancer, Hypoxia, and MetabolismCancer-related molecular mechanisms research

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A MicroRNA Signature of Hypoxia

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Kulshreshtha, Ritu, Ferracin, Manuela, Wojcik, Sylwia E., Garzon, Ramiro, Alder, Hansjuerg, Agosto-Perez, Francisco J., Davuluri, Ramana, Liu, Chang-Gong, Croce, Carlo M., Negrini, Massimo, Calin, George A., Ivan, Mircea·2007·Molecular and Cellular Biology

DOI 10.1128/mcb.01395-06PMC PMC1820461

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Abstract

Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.

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Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Self-citation
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“to-alanine substitutions have been described previously (14, 15).”
MethodSelf-citation
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Self-citation
miRBase: microRNA sequences, targets and gene nomenclature
Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950

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Winther, M., Alsner, J., Sørensen, B. S., Wittrup, C. F., Tramm, T., Bæksgaard, L., Hofland, K. F., Holtved, E., & Nordsmark, M. (2016) · PubMed · Cited by 7
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Zhang, X., Meng, Z., Yang, C., Wang, C., Zhang, K., Shi, A., Guo, J., Feng, Y., & Zeng, Y. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1486252 · Cited by 5
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Neculachi, C. A., Nastase-Rusu, E.-G., Cherry, L., Marinescu-Colan, C. I., Tastsoglou, S., Cosman, B., Popa, A. M., Panciuc, C., Zaccagnini, G., Catrina, S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1633163 · Cited by 5
Hypoxic/Ischemic Inflammation, MicroRNAs and δ-Opioid Receptors: Hypoxia/Ischemia-Sensitive Versus-Insensitive Organs
Chen, Y., He, Y., Zhao, S., He, X., Xue, D. Q., & Xia, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.847374 · Cited by 5
The Tyr113His T/C rs1051740 and ‘very slow’ phenotype of the EPHX1 gene alters miR-26b-5p and miR-1207-5p expression in pregnancy
Naidoo, P., Naidoo, R. N., Ramkaran, P., Asharam, K., & Chuturgoon, A. A. (2017) · Gene · doi:10.1016/j.gene.2017.07.080 · Cited by 5
MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma
Giubellino, A., Ricketts, C. J., Moreno, V., Linehan, W. M., & Merino, M. J. (2021) · Journal of Cancer · doi:10.7150/jca.52310 · Cited by 5
MicroRNA Biogenesis in Regenerative Medicine
Ghatak, S., & Sen, C. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00001-0 · Cited by 5
miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment
Chen, F., Wang, R., Li, G., Zhang, Y., Yu, S., Liu, Y., Chen, X., & Hou, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9570 · Cited by 5
Methods of Quantifying MicroRNAs for Hypoxia Research: Classic and Next Generation
Radovich, M., & Ragoussis, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5716 · Cited by 5
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Calin, G. A., & Pardini, B. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0057-4 · Cited by 5
Self-citation
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Lin, S.-S., Ueng, S. W., Chong, K., Chan, Y., Tsai, T., Yuan, L., Liu, S., Yang, C.-Y., Hsiao, H., Hsueh, Y., et al. (2023) · Cells · doi:10.3390/cells12162111 · Cited by 4
MiRNA expression affects survival in patients with obstructive sleep apnea and metastatic colorectal cancer
Soccio, P., Moriondo, G., Scioscia, G., Tondo, P., Bruno, G., Giordano, G., Sabato, R., Barbaro, M. P. F., Landriscina, M., & Lacedonia, D. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.09.008 · Cited by 5
Micro-Ribonucleic Acid Profiles From Microarray in Ankylosing Spondylitis
Jin, H., Young-Nan, C. H. O., Kee, S., Shin-Seok, L. E. E., Yong-Wook, P. A. R. K., & Tae-Jong, K. I. M. (2016) · Archives of Rheumatology · doi:10.5606/archrheumatol.2016.5733 · Cited by 4
MicroRNAs: The Master Regulators of the Breast Cancer Tumor Microenvironment
Feser, R., Opperman, R. M., Maiti, S., & Majumder, M. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_239-1 · Cited by 4
Analysis of nocturnal, hypoxia-induced miRNAs in sleep apnea patients
Goody, P. R., Nachtsheim, L., Hosen, M. R., von Krosigk, M., Christmann, D., Klußmann, J. P., Zietzer, A., Breitrück, N., Jansen, F., & Jansen, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263747 · Cited by 5
MicroRNA Regulation of Angiogenesis
Chan, Y. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00027-7 · Cited by 4
Ssc-miR-141 Attenuates Hypoxia-Induced Alveolar Type II Epithelial Cell Injury in Tibetan Pigs by Targeting PDCD4
Xu, L., Yuan, H., Wang, Z., Zhao, S., & Yang, Y. (2022) · Genes · doi:10.3390/genes13122398 · Cited by 4
Role of microRNAs in solid tumors.
Fedyanin, M. Y., Ignatova, E., & Tyulyandin, S. А. (2015) · Malignant tumours · doi:10.18027/2224-5057-2013-1-3-14 · Cited by 4
РЕГУЛЯЦИЯ АКТИВНОСТИ микроРНК ПРИ СТРЕССЕ, "Молекулярная биология"
Funikov, S. Y., & Zatsepina, O. G. (2017) · Molecular Biology · doi:10.7868/s0026898417030053 · Cited by 4
Aberrant microRNA expression in the development of breast carcinoma
Wu, Q., Li, H., Lu, J., Ge, Q., & Lu, Z. (2010) · Chinese Science Bulletin · doi:10.1007/s11434-010-4022-6 · Cited by 4
MicroRNAs as Epigenetic Targets of Cigarette Smoke During Embryonic Development
Seelan, R. S., Greene, R. M., & Pisano, M. M. (2019) · MicroRNA · doi:10.2174/2211536608666190926114704 · Cited by 4
Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk
Gomez, R., Sun, W., Shyy, M., Ou, Y.-S. J., Sihota, A., Liu, B., Mesarwi, O. A., & Malhotra, A. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322874 · Cited by 3
Changes in the Expression of miRNA Isoforms and Their Targets in HT-29 Cells after Hypoxic Exposure
Raigorodskaya, M. P., Zhiyanov, A., Averinskaya, D. A., & Tonevitsky, E. A. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05506-2 · Cited by 3
MiR ‐26a and miR ‐191 are upregulated while PLAG1 and HIF2 are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors
Čarkić, J., Nikolić, N., Sango, V., Riberti, N., Aničić, B., & Milašin, J. (2024) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13565 · Cited by 3
Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer
Liu, D., Liu, L., Che, X., & Wu, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1525345 · Cited by 4
MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer
Ferracin, M., & Lupini, L. (2014) · Springer eBooks · doi:10.1007/978-3-319-03725-7_14 · Cited by 3
Self-citation
Genetic Instability Induced by Hypoxic Stress
Scanlon, S. E., & Glazer, P. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6280-4_8 · Cited by 3
Effect of positive pressure ventilation and bariatric surgery on extracellular vesicle microRNAs in patients with severe obesity and obstructive sleep apnea
Lázaro, J., Sánz-Rubio, D., Clavería, P., Cabrejas, C., Fernando, J., Castanera, A., & Marín, J. M. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01230-z · Cited by 5
NF-κB Transcriptional Activity Indispensably Mediates Hypoxia–Reoxygenation Stress-Induced microRNA-210 Expression
Marwarha, G., Slagsvold, K. H., & Høydal, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076618 · Cited by 3
Cross-Sectional Analysis of Hypoxia-Regulated miRNA-181a, miRNA-199a, HIF-1α, and SIRT1 in the Development of Type 2 Diabetes in Patients with Obstructive Sleep Apnea—Preliminary Study
Karuga, F. F., Kaczmarski, P., Sochal, M., Szmyd, B. M., Białasiewicz, P., & Gabryelska, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247644 · Cited by 3

Authors: Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., Calin, G. A., & Ivan, M.
Affiliations: Tufts Medical Center (US)
University of Ferrara (IT)
The Ohio State University (US)
Comprehensive Cancer Center, Ohio State University
Corresponding author: Ivan, Mircea
ORCID: Kulshreshtha, Ritu
Ferracin, Manuela
Wojcik, Sylwia E.
Garzon, Ramiro
Agosto-Perez, Francisco J.
Davuluri, Ramana
Croce, Carlo M.
Negrini, Massimo
Calin, George A.
Ivan, Mircea
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2007-03-01
Volume: 27
Issue: 5
Pages: 1859-1867
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.01395-06
PMC: PMC1820461
OpenAlex: W2116000203
Cited by: 1,055
References: 31
Citations by year: 2026: 11 · 2025: 19 · 2024: 26 · 2023: 32 · 2022: 45 · 2021: 50 · 2020: 43 · 2019: 54 · 2018: 38 · 2017: 70 · 2016: 63 · 2015: 73 · 2014: 91 · 2013: 93 · 2012: 81
FWCI: 16.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-34928, P30DK034928)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, hypoxia, hypoxia-inducible factor, miR-210, miR-26, miR-107, tumor microenvironment, tumor formation, apoptosis, miRNA expression profiling, non-coding RNA regulation
MeSH terms: Breast Neoplasms, Colonic Neoplasms, Female, Humans, Luciferases, Plasmids, Transfection, Cell Hypoxia, Apoptosis, Genes, Reporter, HT29 Cells, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, HCT116 Cells, Cell Line, Tumor, Chromatin Immunoprecipitation

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A MicroRNA Signature of Hypoxia

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