Cited by 310Connective Tissue Growth Factor ResearchSignaling Pathways in DiseaseProtein Kinase Regulation and GTPase Signaling

The DOI matches its Crossref record; 62 of the 64 references it cites were found in a registry or an index, and 2 are not checked yet.

Expression of cyr61, a growth factor-inducible immediate-early gene.

Open access

O'Brien, T P, Yang, G P, Sanders, L, Lau, L F·1990·Molecular and Cellular Biology

DOI 10.1128/mcb.10.7.3569PMC PMC360792

Open this paper in CoChat — free account

Abstract

A set of immediate-early genes that are rapidly activated by serum or purified platelet-derived growth factor in mouse 3T3 fibroblasts has been previously identified. Among these genes, several are related to known or putative transcription factors and growth factors, supporting the notion that some of these genes encode regulatory molecules important to cell growth. We show here that a member of this set of genes, cyr61 (originally identified by its cDNA 3CH61), encodes a 379-amino-acid polypeptide rich in cysteine residues. cyr61 can be induced through protein kinase C-dependent and -independent pathways. Unlike many immediate-early genes that are transiently expressed, the cyr61 mRNA is accumulated from the G0/G1 transition through mid-G1. This expression pattern is due to persistent transcription, while the mRNA is rapidly turned over during the G0/G1 transition and in mid-G1 at the same rate. In logarithmically growing cells, the cyr61 mRNA level is constant throughout the cell cycle. Cyr61 contains an N-terminal secretory signal sequence; however, it is not detected in the culture medium by immunoprecipitation. Cyr61 is synthesized maximally at 1 to 2 h after serum stimulation and has a short half-life within the cell.

Integrity signals

Registry

Crossref · 10.1128/mcb.10.7.3569

Cites

62 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M. E., & Ziff, E. B. (1984) · Nature · doi:10.1038/311433a0 · Cited by 2,992
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Early Signals in the Mitogenic Response
Rozengurt, E. (1986) · Science · doi:10.1126/science.3018928 · Cited by 1,444
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Montminy, M., Sevarino, K. A., Wagner, J. A., Mandel, G., & Goodman, R. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6682 · Cited by 1,385
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
Sukhatme, V. P., Cao, X., Chang, L. C., Tsai‐Morris, C., Stamenkovich, D., Ferreira, P. C. P., Cohén, D., Edwards, S. A., Shows, T. B., Curran, T., et al. (1988) · Cell · doi:10.1016/0092-8674(88)90485-0 · Cited by 1,249

Flagged first, then by citations

Show all 58 references

Sorted by citations

Items 101–200 of 310

Alternative Splicing of Cyr61 Is Regulated by Hypoxia and Significantly Changed in Breast Cancer
Hirschfeld, M., zur Hausen, A., Bettendorf, H., Jäger, M., & Stickeler, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1997 · Cited by 86
Transcriptional Down Regulation of the nov Proto-Oncogene in Fibroblasts Transformed by p60 v- src
Scholz, G. M., Martinerie, C., Perbal, B., & Hanafusa, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.481 · Cited by 86
Untitled work
(1992) · PubMed · Cited by 85
Differential Regulation of Immediate Early Gene Expression in Preadipocyte Cells through Multiple Signaling Pathways
Inuzuka, H., Nanbu-Wakao, R., Masuho, Y., Muramatsu, M.-A., Tojo, H., & Wakao, H. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1734 · Cited by 84
Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways
Han, J., Macarak, E. J., Rosenbloom, J., Chung, K. C., & Chaqour, B. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03723.x · Cited by 82
Glucocorticoid-attenuated Response Genes Encode Intercellular Mediators, Including a New C-X-C Chemokine
Smith, J. B., & Herschman, H. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16756 · Cited by 80
The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
Crawford, D. F., & Piwnica-Worms, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103414200 · Cited by 79
Distribution of IGFBP-rP1 in Normal Human Tissues
Degeorges, A., Wang, F., Frierson, H. F., Seth, A. K., & Sikes, R. A. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800603 · Cited by 79
Mutations in the Norrie disease gene
Schuback, D. E., Chen, Z. Y., Craig, I., Breakefield, X. O., & Sims, K. B. (1995) · Human Mutation · doi:10.1002/humu.1380050403 · Cited by 78
Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy
MATSUI, Y. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.012 · Cited by 78
Muscarinic Acetylcholine Receptors Induce the Expression of the Immediate Early Growth Regulatory Gene CYR61
Albrecht, C., von der Kammer, H., Mayhaus, M., Klaudiny, J., Schweizer, M., & Nitsch, R. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003053200 · Cited by 74
Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling
Mh, Y., Lin, B.-R., Chang, C., Chen, S.-T., Lin, S.-K., Kuo, M. Y.-P., Jeng, Y., Kuo, M.-L., & Chang, C. (2011) · Oncogene · doi:10.1038/onc.2011.423 · Cited by 73
Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)
Leu, S.-J., Chen, N., Chen, C.-C., Todorović, V., Bai, T., Juric, V., Liu, Y., Yan, G., Lam, S. C.-T., & Lau, L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407850200 · Cited by 72
Self-citation
Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer
Holloway, S. E., Beck, A. W., Girard, L., Jaber, R., Barnett, C. C., Brekken, R. A., & Fleming, J. B. (2005) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2004.10.005 · Cited by 72
Transforming growth factor-beta-stimulated connective tissue growth factor expression during corneal myofibroblast differentiation.
Folger, P. A., Zekaria, D., Grotendorst, G. R., & Masur, S. K. (2001) · PubMed · Cited by 72
Insulin‐like growth factor binding proteins: a proposed superfamily
Hwa, V., Oh, Y., & Rosenfeld, R. G. (1999) · Acta Paediatrica · doi:10.1111/j.1651-2227.1999.tb14349.x · Cited by 72
Modularity of the slit protein
Rothberg, J. M., & Artavanis‐Tsakonas, S. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90891-m · Cited by 71
Coxsackievirus B3 Infection Induces cyr61 Activation via JNK To Mediate Cell Death
Kim, S.-M., Park, J.-H., Chung, S.-K., Kim, J.-Y., Hwang, H.-Y., Chung, K.-C., Jo, I., Park, S.-I., & Nam, J.-H. (2004) · Journal of Virology · doi:10.1128/jvi.78.24.13479-13488.2004 · Cited by 70
Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen
Rivera-Gonzalez, R., Petersen, D. N., Tkalcevic, G. T., Thompson, D. D., & Brown, T. A. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00142-8 · Cited by 70
Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues
Maillard, M. (2001) · Molecular Pathology · doi:10.1136/mp.54.4.275 · Cited by 69
Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression
Perbal, B. (1999) · Molecular Pathology · doi:10.1136/mp.52.2.84 · Cited by 69
Regulation of connective tissue growth factor expression by prostaglandin E2
Ricupero, D. A., Rishikof, D. C., Kuang, P., Poliks, C. F., & Goldstein, R. H. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1165 · Cited by 69
The CCN family of genes: a brief history
Perbal, B. (2001) · Molecular Pathology · doi:10.1136/mp.54.2.103 · Cited by 69
Identification of differentially expressed genes induced by transient ischemic stroke
Schwarz, D. A., Barry, G., Mackay, K. B., Manu, F., Naeve, G. S., Vana, A. M., Verge, G., Conlon, P. J., Foster, A. C., & Maki, R. A. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00135-3 · Cited by 65
CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts
Kothapalli, D., & Grotendorst, G. R. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200001)182:1 · Cited by 66
CCN Proteins Are Distinct from, and Should Not Be Considered Members of, the Insulin-Like Growth Factor-Binding Protein Superfamily
Grotendorst, G. R., Lau, L. F., & Perbal, B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7241-1 · Cited by 62
Self-citation
Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs
Shimo, T., Wu, C., Billings, P. C., Piddington, R., Rosenbloom, J., Pacifici, M., & Koyama, E. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10109 · Cited by 61
Promoter Function of the Angiogenic Inducer Cyr61Gene in Transgenic Mice: Tissue Specificity, Inducibility During Wound Healing, and Role of the Serum Response Element
Latinkic, B. V. (2001) · Endocrinology · doi:10.1210/en.142.6.2549 · Cited by 61
Expression of the human NOV gene in first trimester fetal tissues
Kocialkowski, S., Yeger, H., Kingdom, J. C., Perbal, B., & Schofield, P. N. (2001) · Anatomy and Embryology · doi:10.1007/s004290100177 · Cited by 63
Conditional Overexpression of Connective Tissue Growth Factor Disrupts Postnatal Lung Development
WU, S. M., Platteau, A., Chen, S., McNamara, G. T., Whitsett, J. A., & Bancalari, E. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0068oc · Cited by 60
Bone Structure, Development and Bone Biology
Safadi, F. F., Barbe, M. F., Abdelmagid, S. M., Rico, M. C., Aswad, R. A., Litvin, J., & Popoff, S. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-347-9_1 · Cited by 75
The Human Analog of Murine Cystein Rich Protein 16 Is a 1 ,25-Dihydroxyvitamin D3 Responsive Immediate Early Gene in Human Fetal Osteoblasts: Regulation by Cytokines, Growth Factors, and Serum
Schütze, N., Lechner, A., Groll, C., Siggelkow, H., Hüfner, M., Köhrle, J., & Jakob, F. J. (1998) · Endocrinology · doi:10.1210/endo.139.4.5954 · Cited by 60
CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model
Matsumae, H., Yoshida, Y., Ono, K., Togi, K., Inoue, K., Furukawa, Y., Nakashima, Y., Kojima, Y., Nobuyoshi, M., Kita, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.162362 · Cited by 59
CCN1 protects cardiac myocytes from oxidative stress via β1 integrin–Akt pathway
Yoshida, Y., Togi, K., Matsumae, H., Nakashima, Y., Kojima, Y., Yamamoto, H., Ono, K., Nakamura, T., Kita, T., & Tanaka, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.195 · Cited by 59
Stimulation of Angiogenesis by Cyr61 Gene: A New Therapeutic Candidate
Fataccioli, V., Abergel, V., Wingertsmann, L., Neuville, P., Spitz, E., Adnot, S., Calenda, V., & Teiger, E. (2002) · Human Gene Therapy · doi:10.1089/10430340260185094 · Cited by 58
The Matricellular Protein CYR61 Inhibits Osteoclastogenesis by a Mechanism Independent of αvβ3 and αvβ5
Crockett, J. C., Schütze, N., Tosh, D., Jatzke, S., Duthie, A., Jakob, F., & Rogers, M. J. (2007) · Endocrinology · doi:10.1210/en.2007-0473 · Cited by 57
Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation
Liu, C., Liu, X.-J., Crowe, P. D., Kelner, G. S., Fan, J., Barry, G., Manu, F., LING, N. C., Souza, E. B. D., & Maki, R. A. (1999) · Gene · doi:10.1016/s0378-1119(99)00364-9 · Cited by 56
Differential expression of connective tissue growth factor gene in cutaneous fibrohistiocytic and vascular tumors
Igarashi, A., Hayashi, N., Nashiro, K., & Takehara, K. (1998) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1998.tb01706.x · Cited by 55
CYR61 (CCN1) Protein Expression during Fracture Healing in an Ovine Tibial Model and Its Relation to the Mechanical Fixation Stability
Lienau, J., Schell, H., Epari, D. R., Schütze, N., Jakob, F. J., Duda, G. N., & Bail, H. J. (2005) · Journal of Orthopaedic Research® · doi:10.1002/jor.20035 · Cited by 54
Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1
Grote, K., Bavendiek, U., Grothusen, C., Flach, I., Hilfiker-Kleiner, D., Drexler, H., & Schieffer, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406532200 · Cited by 52
Differential expression of novH and CTGF in human glioma cell lines
Xin, L. W., Martinerie, C., Zumkeller, W., Westphal, M., & Perbal, B. (1996) · Molecular Pathology · doi:10.1136/mp.49.2.m91 · Cited by 52
Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response
Feng, P., Wang, B., & Ren, E. C. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.06.020 · Cited by 51
Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology?
Miyamoto, S., Re, D. P. D., Xiang, S. Y., Zhao, X., Florholmen, G., & Brown, J. H. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9192-8 · Cited by 51
Role of the CCN protein family in cancer
Kim, H., Son, S., & Shin, I. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.10.192 · Cited by 53
New strategy to control cell migration and metastasis regulated by CCN2/CTGF
Aguiar, D. P., de Farias, G. C., de Sousa, E. B., Coelho‐Aguiar, J. D. M., Lobo, J. C., Casado, P. L., Duarte, M. E. L., & Abreu, J. G. (2014) · Cancer Cell International · doi:10.1186/1475-2867-14-61 · Cited by 53
The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells
Bartholin, L., Wessner, L. L., Chirgwin, J. M., & Guise, T. A. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.02.019 · Cited by 53
The role of the CCN family of proteins in female reproduction
Winterhager, E., & Gellhaus, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1556-9 · Cited by 52
Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity
Ahmed, S., Yamamoto, K., Sato, Y., Ogawa, T., Herrmann, A., Higashi, S., & Miyazaki, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.058 · Cited by 48
Cloning the full-length cDNA for rat connective tissue growth factor: Implications for skeletal development
Xu, J., Smock, S. L., Safadi, F. F., Rosenzweig, A. B., Odgren, P. R., Marks, S. C., Owen, T. A., & Popoff, S. N. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000401)77:1 · Cited by 48
Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine‐rich protein 61
Walsh, C. T., Radeff‐Huang, J., Matteo, R., Hsiao, A., Subramaniam, S., Stupack, D., & Brown, J. H. (2008) · The FASEB Journal · doi:10.1096/fj.08-113266 · Cited by 47
COP‐1, a member of the CCN family, is a heparin‐induced growth arrest specific gene in vascular smooth muscle cells
Delmolino, L. M., Stearns, N. A., & Castellot, J. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1100 · Cited by 47
Localization of connective tissue growth factor in human uterine tissues
Uzumcu, M. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.12.1093 · Cited by 47
Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells
Lee, Y., Lee, D. M., & Lee, S.-H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.04.035 · Cited by 46
The stability of the transcriptome during the estrous cycle in four regions of the mouse brain
DiCarlo, L. M., Vied, C., & Nowakowski, R. S. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24282 · Cited by 45
Regulation of Cyr61/CCN1 expression by hypoxia through cooperation of c-Jun/AP-1 and HIF-1α in retinal vascular endothelial cells
You, J.-J., Yang, C., Chen, M., & Yang, C. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.10.006 · Cited by 43
Regenerating CNS myelin: Emerging roles of regulatory T cells and CCN proteins
Gallardo, N. D. L. V., Dittmer, M., Dombrowski, Y., & Fitzgerald, D. C. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.11.024 · Cited by 42
Mesenchymal stem cell‐derived CCN 2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells
Wu, Y., Li, H., Zhao, X., Jiao, J., Tang, D., Yan, L., Wan, Q., & Pan, C. (2017) · Cancer Science · doi:10.1111/cas.13202 · Cited by 42
Endometrial Expression of Cyr61
MacLaughlan, S. D., Palomino, W. A., Mo, B., Lewis, T. D., Lininger, R. A., & Lessey, B. A. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000269047.46078.28 · Cited by 42
G Protein-Coupled Receptors Go Extracellular: RhoA Integrates the Integrins
Walsh, C. T., Stupack, D., & Brown, J. H. (2008) · Molecular Interventions · doi:10.1124/mi.8.4.8 · Cited by 40
Emerging role of CCN family proteins in fibrosis
Sun, C., Zhang, H., & Liu, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30171 · Cited by 45
Expression of Angiogenic Factor Cyr61 during Neuronal Cell Death via the Activation of c-Jun N-terminal Kinase and Serum Response Factor
Kim, K. H., Min, Y. K., Baik, J., Lau, L. F., Chaqour, B., & Chung, K. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210128200 · Cited by 40
Self-citation
Expression of Nov, CYR61 and CTGF genes in human hepatocellular carcinoma
Hirasaki, S. (2001) · Hepatology Research · doi:10.1016/s1386-6346(00)00101-7 · Cited by 40
Kinetics of Expression of Connective Tissue Growth Factor Gene during Liver Regeneration after Partial Hepatectomy and -Galactosamine-Induced Liver Injury in Rats
Ujike, K., Shinji, T., Hirasaki, S., Shiraha, H., Nakamura, M., Tsuji, T., & Koide, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3693 · Cited by 40
A Key Role for Cyclic AMP-Responsive Element Binding Protein in Hypoxia-Mediated Activation of the Angiogenesis Factor CCN1 (CYR61) in Tumor Cells
Meyuhas, R., Pikarsky, E., Tavor, E., Klar, A., Abramovitch, R., Hochman, J., Lago, T. G., & Honigman, A. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2086 · Cited by 39
Bone Structure, Development and Bone Biology
Khurana, J. S., & Safadi, F. F. (2009) · Springer eBooks · doi:10.1007/978-0-387-89845-2_1 · Cited by 41
Expression of Heregulin in Human Coronary Atherosclerotic Lesions
Panutsopulos, D., Arvanitis, D. L., Tsatsanis, C., Papalambros, E. L., Sigala, F., & Spandidos, D. A. (2005) · Journal of Vascular Research · doi:10.1159/000088100 · Cited by 39
Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3
Varnum, B. C., Reddy, S. T., Koski, R. A., & Herschman, H. R. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580125 · Cited by 39
The MET receptor tyrosine kinase contributes to invasive tumour growth in rhabdomyosarcomas
Rees, H., Williamson, D., Papanastasiou, A., Jina, N., Nabarro, S., SHIPLEY, J. M., & Anderson, J. (2006) · Growth Factors · doi:10.1080/08977190600759923 · Cited by 38
The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development
Schonbaum, C. P., Organ, E. L., Qu, S., & Cavener, D. R. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90183-h · Cited by 38
The Expression of novH in Adrenocortical Cells Is Down-regulated by TGFβ1 through c-Jun in a Smad-independent Manner
Lafont, J. E., Laurent, M., Thibout, H., Lallemand, F., Bouc, Y. L., Atfi, A., & Martinerie, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204405200 · Cited by 39
CYR61 (CCN1) overexpression induces lung injury in mice
Grazioli, S., Gil, S., An, D., Kajikawa, O., Farnand, A. W., Hanson, J. F., Birkland, T. P., Chen, P., Duffield, J. S., Schnapp, L. M., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00190.2014 · Cited by 37
Proteolysis of CCN1 by Plasmin: Functional Implications
Pendurthi, U. R., Tran, T. T., Post, M., & Rao, L. V. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0982 · Cited by 38
Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection
Zhao, X., Ding, E., Yu, O. M., Xiang, S. Y., Tan‐Sah, V. P., Yung, B. S., Hedgpeth, J., Neubig, R. R., Lau, L. F., Brown, J. H., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.017 · Cited by 37
Self-citation
Transcriptional activation of the immediate early gene pip92 by serum growth factors requires both Ets and CArG-like elements.
Latinkic, B., & Lau, L. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31634-4 · Cited by 36
Self-citation
Isolation and characterization of xnov, a Xenopus laevis ortholog of the chicken nov gene
Ying, Z., & King, M. L. (1996) · Gene · doi:10.1016/0378-1119(95)00891-8 · Cited by 36
CCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS‐4 (Aggrecanase 1) Activity
Chijiiwa, M., Mochizuki, S., Kimura, T., Abe, H., Tanaka, Y., Fujii, Y., Shimizu, H., Enomoto, H., Toyama, Y., & Okada, Y. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39078 · Cited by 35
The Roles of CCN1/CYR61 in Pulmonary Diseases
Zhu, Y., Almuntashiri, S., Han, Y., Wang, X., Somanath, P. R., & Zhang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217810 · Cited by 37
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic
Sarkar, S., Quinn, B. A., Shen, X., Dash, R., Das, S. K., Emdad, L., Klibanov, A. L., Wang, X., Pellecchia, M., Sarkar, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3544 · Cited by 35
Identification of genes regulated by muscarinic acetylcholine receptors: application of an improved and statistically comprehensive mRNA differential display technique
von der Kammer, H., Albrecht, C., Mayhaus, M., Hoffmann, B., Stanke, G., & Nitsch, R. M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.10.2211 · Cited by 35
Genetic selection of growth-inhibitory sequences in mammalian cells.
Pestov, D. G., & Lau, L. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12549 · Cited by 35
Self-citation
Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3—modulated adhesion and invasion
Kassis, J. N., Virador, V. M., Guancial, E. A., Kimm, D., Ho, A. S., Mishra, M., Chuang, E. Y., Cook, J., Gius, D., & Kohn, E. C. (2009) · The Journal of Pathology · doi:10.1002/path.2557 · Cited by 34
CCN1 Secreted by Tonsil‐Derived Mesenchymal Stem Cells Promotes Endothelial Cell Angiogenesis via Integrin αvβ3 and AMPK
Park, Y. S., Hwang, S., Jin, Y. M., Yu, Y., Jung, S., Jung, S., Ryu, K., Kim, H. S., & Jo, I. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24690 · Cited by 35
Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression
Gressner, O. A., Lahme, B., Siluschek, M., Rehbein, K., Weiskirchen, R., & Gressner, A. M. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01729.x · Cited by 34
A novel mechanism of plasmin-induced mitogenesis in fibroblasts
MANDAL, S. K., Rao, L. V. M., Tran, T. T., & Pendurthi, U. R. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01054.x · Cited by 35
Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)
Yang, R., Chen, Y., & Chen, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7880 · Cited by 34
The Emerging Roles of CCN3 Protein in Immune‐Related Diseases
Peng, L., Wei, Y., Shao, Y., Li, Y., Liu, N., & Duan, L. (2021) · Mediators of Inflammation · doi:10.1155/2021/5576059 · Cited by 34
The immediate early gene product hCYR61 localizes to the secretory pathway in human osteoblasts
Lechner, A., Schütze, N., Siggelkow, H., Seufert, J., & Jakob, F. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00294-5 · Cited by 33
Pip92: A Short-Lived, Growth Factor-Inducible Protein in BALB/c 3T3 and PC12 Cells
Charles, C. H., Simske, J. S., O'Brien, T. P., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6769 · Cited by 33
Self-citation
The Product of a Novel Growth Factor-Activated Gene, fic, Is a Biologically Active "C-C"-Type Cytokine
Heinrich, J. N., Ryseck, R.-P., Macdonald-Bravo, H., & Bravo, R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2020 · Cited by 33
Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients
Wang, B., Ren, J., Ooi, L. L., Chong, S. S., & Lee, C. G. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208550 · Cited by 32
Expression of CCN family of genes in human skin in vivo and alterations by solar-simulated ultraviolet irradiation
Quan, T., Shin, S. J., Qin, Z., & Fisher, G. J. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0044-8 · Cited by 35
CCN proteins as potential actionable targets in scleroderma
Henrot, P., Truchetet, M., Fisher, G. J., Taïeb, A., & Cario, M. (2018) · Experimental Dermatology · doi:10.1111/exd.13806 · Cited by 31
5′ flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus
Schütze, N., Rücker, N., Müller, J., Adamski, J., & Jakob, F. J. (2001) · Molecular Pathology · doi:10.1136/mp.54.3.170 · Cited by 31
Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines
Moritani, N. H., Kubota, S., Sugahara, T., & Takigawa, M. (2005) · Cell Communication and Signaling · doi:10.1186/1478-811x-3-6 · Cited by 31
A developmental study of novH gene expression in human central nervous system
Su, B., Wq, C., Zhang, C., Huici, S., & Perbal, B. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(99)80002-x · Cited by 31
Antiangiogenic Domains Shared by Thrombospondins and Metallospondins, a New Family of Angiogenic Inhibitors
Iruela‐Arispe, M. L., Vázquez, F., & Ortega, M.-A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09400.x · Cited by 30
O‐fucosylation of CCN1 is required for its secretion
Niwa, Y., Suzuki, T., Dohmae, N., & Simizu, S. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.012 · Cited by 29
Cyr61 is a potential prognostic marker for prostate cancer
Terada, N., Kulkarni, P., & Getzenberg, R. H. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.149 · Cited by 29
Establishment of Cell Lines with High‐ and Low‐metastatic Potential from PC‐14 Human Lung Adenocarcinoma
Shindo‐Okada, N., Takeuchi, K., & Nagamachi, Y. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01080.x · Cited by 29
The CCN family of proteins: a 25th anniversary picture
Perbal, A., & Perbal, B. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0340-z · Cited by 28

Authors: O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F.
Affiliations: University of Illinois Chicago (US)
ORCID: Yang, G P
Lau, L F
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1990-07
Volume: 10
Issue: 7
Pages: 3569-3577
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.10.7.3569
PMC: PMC360792
OpenAlex: W1793987231
Cited by: 310
References: 58
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 6 · 2013: 4 · 2012: 2
FWCI: 2.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: American Cancer Society
March of Dimes Foundation
National Institutes of Health
National Cancer Institute (R01CA046565, R01CA052220)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: CYR61, immediate early genes, platelet-derived growth factor, serum stimulation, 3T3 fibroblasts, protein kinase C, cell cycle regulation, mRNA turnover, secretory signal sequence, gene expression regulation, cell growth
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cell Division, Cell Line, Cells, Cultured, Culture Media, DNA, Genes, Growth Substances, Humans, Molecular Sequence Data, Platelet-Derived Growth Factor, Proteins, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Restriction Mapping, Gene Expression, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Mice, Cysteine-Rich Protein 61

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of cyr61, a growth factor-inducible immediate-early gene.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks