Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works

Superoxide radical and superoxide dismutases

Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455 · see citing works

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

Superoxide Dismutases

Fridovich, I. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.001051 · Cited by 1,735 · see citing works

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

Osborn, L., Hession, C. A., Tizard, R., Vassallo, C., Luhowskyj, S., Rosso, G. C., & Lobb, R. R. (1989) · Cell · doi:10.1016/0092-8674(89)90775-7 · Cited by 1,690 · see citing works

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663 · see citing works

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

Osborn, L., Kunkel, S. L., & Nabel, G. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2336 · Cited by 1,642 · see citing works

The “initiator” as a transcription control element

Smale, S. T., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90176-1 · Cited by 1,572 · see citing works

Oxidative stress: the paradox of aerobic life

Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150 · see citing works

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

Beg, A. A., Finco, T. S., Nantermet, P. V., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3301 · Cited by 1,027 · see citing works

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works

Mitochondrial Superoxide Dismutase

Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43735-6 · Cited by 960 · see citing works

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

Mueller, P. R., & Wold, B. J. (1989) · Science · doi:10.1126/science.2814500 · Cited by 926 · see citing works

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914 · see citing works

Superoxide Dismutase

Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43969-0 · Cited by 895 · see citing works

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802 · see citing works

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

Birkenmeier, E. H., Gwynn, B., Howard, S., Jerry, J., Gordon, J. I., Landschulz, W. H., & McKnight, S. L. (1989) · Genes & Development · doi:10.1101/gad.3.8.1146 · Cited by 613 · see citing works

Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction

Stein, B., Cogswell, P. C., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3964 · Cited by 516 · see citing works

Cell and tissue responses to oxidative damage.

Janssen-Heininger, Y. M. W., Houten, B. V., Borm, P. J. A., & Mossman, B. T. (1993) · PubMed · Cited by 488 · see citing works

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

KUNSCH, C. A., Ruben, S. M., & Rosen, C. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4412-4421.1992 · Cited by 488 · see citing works

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

Smale, S. T., Schmidt, M. C., Berk, A. J., & Baltimore, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4509 · Cited by 481 · see citing works

Tumor necrosis factors: developments during the last decade.

Aggarwal, B. B., & Natarajan, K. (1996) · PubMed · Cited by 469 · see citing works

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77165-2 · Cited by 419 · see citing works

Functional analysis of the human vascular cell adhesion molecule 1 promoter.

Neish, A. S., Williams, A. J., Palmer, H. J., Whitley, M. Z., & Collins, T. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1583 · Cited by 416 · see citing works

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

Lamers, W. H., Hanson, R. W., & Meisner, H. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.17.5137 · Cited by 410 · see citing works

Tumor necrosis factor receptor-mediated signaling pathways.

Heller, R. A., & Krönke, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.5 · Cited by 392 · see citing works

Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.

Visner, G. A., Dougall, W. C., Wilson, J. M., Burr, I. A., & Nick, H. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39880-1 · Cited by 376 · see citing works

Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression.

Schindler, U., & Baichwal, V. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5820 · Cited by 328 · see citing works

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

Kunsch, C., Ruben, S. M., & Rosen, C. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4412 · Cited by 295 · see citing works

Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

Radeke, H. H., Meier, B., Topley, N., Flöge, J., Habermehl, G., & Resch, K. (1990) · Kidney International · doi:10.1038/ki.1990.44 · Cited by 279 · see citing works

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

John, S., Reeves, R., Lin, J., Child, R., Leiden, J. M., Thompson, C. B., & Leonard, W. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1786 · Cited by 241 · see citing works

Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

Hou, J., Baichwal, V. R., & Cao, Z. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11641 · Cited by 217 · see citing works

Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors

Sancéau, J., Kaisho, T., Hirano, T., & Wietzerbin, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27920 · Cited by 211 · see citing works

NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.Preprint

Pazin, M. J., Sheridan, P. L., Cannon, K. S., Cao, Z. D., Keck, J., Kadonaga, J. T., & Jones, K. A. (1996) · Genes & Development · doi:10.1101/gad.10.1.37 · Cited by 186 · see citing works

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

Wong, G. H. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00029-4 · Cited by 171 · see citing works

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Gil, G., Smith, J. R., Goldstein, J. L., et al. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8963 · Cited by 169 · see citing works

Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells

Das, K. C., Lewis-Molock, Y., & White, C. W. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.269.5.l588 · Cited by 168 · see citing works

Thiol modulation of TNF? and IL-1 induced MnSOD gene expression and activation of NF-?B

Das, K. C., Lewis-Molock, Y., & White, C. W. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf00929502 · Cited by 129 · see citing works

TNF Regulates the In Vivo Occupancy of Both Distal and Proximal Regulatory Regions of the MCP-1/JE Gene

Ping, D., Jones, P. L., & Boss, J. M. (1996) · Immunity · doi:10.1016/s1074-7613(00)80412-4 · Cited by 125 · see citing works

Irradiation Increases Manganese Superoxide Dismutase mRNA Levels in Human Fibroblasts.

Akashi, M., Hachiya, M., PAQUETTE, R. L., Osawa, Y., Shimizu, S., & Suzuki, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15864 · Cited by 118 · see citing works

Antioxidative Roles of Metallothionein and Manganese Superoxide Dismutase Induced by Tumor Necrosis Factor-α and Interleukin-6

Sato, M., Sasaki, M., & Hojo, H. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1098 · Cited by 110 · see citing works

Leukemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury

NELSON, S., WONG, G., & McCord, J. M. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(08)80021-1 · Cited by 93 · see citing works

NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.

Klampfer, L., Lee, T. H., Hsu, W., Vilček, J., & Chen‐Kiang, S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6561 · Cited by 80 · see citing works

Cloning and characterization of the murine manganous superoxide dismutase-encoding gene

Jones, P. L., Kucera, G., Gordon, H., & Boss, J. M. (1995) · Gene · doi:10.1016/0378-1119(94)00666-g · Cited by 74 · see citing works

Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B.

Laherty, C. D., Perkins, N. D., & Dixit, V. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53498-0 · Cited by 71 · see citing works

Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

Beg, A. A., & Baldwin, A. S. (1994) · PubMed · Cited by 65 · see citing works

Ligation‐Mediated PCR for Genomic Sequencing and Footprinting

Mueller, P. R., Wold, B. J., & Garrity, P. (2001) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb1503s56 · Cited by 64 · see citing works

Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts

Gordon, H., Kucera, G., Salvo, R., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.12.4021 · Cited by 63 · see citing works

Lung Manganese Superoxide Dismutase Increases During Cytokine-Mediated Protection Against Pulmonary Oxygen Toxicity in Rats

Lewis-Molock, Y., Suzuki, K., Taniguchi, N., et al. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.10.2.8110468 · Cited by 52 · see citing works

Interleukin 1α-induced expression of manganous superoxide dismutase reduces myocardial reperfusion injury in the rat

Nogae, C., Makino, N., Hata, T., Nogae, I., Takahashi, S., Suzuki, K., Taniguchi, N., & Yanaga, T. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(95)91155-3 · Cited by 35 · see citing works

Differential induction and decay of manganese superoxide dismutase mRNAs

Melendez, J. A., & Baglioni, C. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90141-g · Cited by 29 · see citing works

Sensitivity to tumour necrosis factor-mediated cytolysis is unrelated to manganous superoxide dismutase messenger RNA levels among transformed mouse fibroblasts.

Boss, J. M., Laster, S. M., & Gooding, L. R. (1991) · PubMed · Cited by 13 · see citing works

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897 · see citing works

Crosstalk of reactive oxygen species and NF-κB signaling

Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505 · see citing works

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666 · see citing works

Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis

Brouard, S., Berberat, P. O., Tobiasch, E., Seldon, M. P., Bach, F. H., & Soares, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108317200 · Cited by 306 · see citing works

Manganese superoxide dismutase regulation and cancer

Dhar, S. K., & St. Clair, D. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.009 · Cited by 196 · see citing works

Manganese superoxide dismutase: Beyond life and death

Holley, A. K., Dhar, S. K., Xu, Y., & St. Clair, D. K. (2012) · Amino Acids · doi:10.1007/s00726-010-0600-9 · Cited by 122 · see citing works

Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility

Raineri, I., Carlson, E. J., Gacayan, R., Carra, S., Oberley, T. D., Huang, T.-T., & Epstein, C. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00686-4 · Cited by 73 · see citing works

Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription

Stees, J. R., Varn, F., Huang, S., Strouboulis, J., & Bungert, J. (2012) · Biology · doi:10.3390/biology1030778 · Cited by 9 · see citing works

Promoter targeting sequence mediates enhancer interference in the Drosophila embryo

Lin, Q., Chen, Q., Lin, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605730104 · Cited by 20 · see citing works

Increased enhancer–promoter interactions during developmental enhancer activation in mammals

Chen, Z., Snetkova, V., Bower, G., Jacinto, S. H., Clock, B., Dizehchi, A., Barozzi, I., Mannion, B. J., Alcaina‐Caro, A., López-Rı́os, J., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01681-2 · Cited by 84 · see citing works

A model of active transcription hubs that unifies the roles of active promoters and enhancers

Zhu, I., Song, W., Ovcharenko, I., & Landsman, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab235 · Cited by 55 · see citing works

Regeneration and Developmental Enhancers Are Differentially Compatible with Minimal PromotersPreprint

Begeman, I. J., Emery, B. F., Kurth, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.20.496839