The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase
Open accessAbstract
Gab1 has structural similarities with Drosophila DOS (daughter of sevenless), which is a substrate of the protein tyrosine phosphatase Corkscrew. Both Gab1 and DOS have a pleckstrin homology domain and tyrosine residues, potential binding sites for various SH2 domain-containing adapter molecules when they are phosphorylated. We found that Gab1 was tyrosine phosphorylated in response to various cytokines, such as interleukin-6 (IL-6), IL-3, alpha interferon (IFN-alpha), and IFN-gamma. Upon the stimulation of IL-6 or IL-3, Gab1 was found to form a complex with phosphatidylinositol (PI)-3 kinase and SHP-2, a homolog of Corkscrew. Mutational analysis of gp130, the common subunit of IL-6 family cytokine receptors, revealed that neither tyrosine residues of gp130 nor its carboxy terminus was required for tyrosine phosphorylation of Gab1. Expression of Gab1 enhanced gp130-dependent mitogen-activated protein (MAP) kinase ERK2 activation. A mutation of tyrosine 759, the SHP-2 binding site of gp130, abrogated the interactions of Gab1 with SHP-2 and PI-3 kinase as well as ERK2 activation. Furthermore, ERK2 activation was inhibited by a dominant negative p85 PI-3 kinase, wortmannin, or a dominant negative Ras. These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2, PI-3 kinase, and Ras are involved in Gab1-mediated ERK activation.
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Principles of interleukin (IL)-6-type cytokine signalling and its regulation
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Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
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IL-6 in inflammation, autoimmunity and cancer
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“The binding of SHP-2 to Y759 mediates activation of the ERK–MAPK cascade via the adaptor molecules GAB1 and GAB2 (106, 107).”
BackgroundSelf-citationRole of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases
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LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
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Metadata
- Authors
- Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., & Hirano, T.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1998-07-01
- Volume
- 18
- Issue
- 7
- Pages
- 4109-4117
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2125543544
- Cited by
- 286
- References
- 50
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase. https://app.cochat.ai/papers/10.1128/mcb.18.7.4109
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- Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., & Hirano, T. (1998). Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.18.7.4109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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