NF-κB RelA Phosphorylation Regulates RelA Acetylation

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 2×

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

Phosphorylated CREB binds specifically to the nuclear protein CBP

Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052

CBP/p300 in cell growth, transformation, and development

Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778

Shaping the nuclear action of NF-κB

Chen, L., & Greene, W. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1368 · Cited by 1,248

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231

β‐Catenin and interleukin‐1β–dependent chemokine (C‐X‐C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis

Kaffe, E., Fiorotto, R., Pellegrino, F., Mariotti, V., Amenduni, M., Cadamuro, M., Fabris, L., Strazzabosco, M., & Spirlı̀, C. (2017) · Hepatology · doi:10.1002/hep.29652 · Cited by 45

Glutamine modulates lipopolysaccharide-induced activation of NF-κB via the Akt/mTOR pathway in lung epithelial cells

Hou, Y., Chiu, W., Yeh, C., & Yeh, S. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00066.2011 · Cited by 45

Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors

Prasad, P., & Sinha, D. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8744-8 · Cited by 43

LncRNA HOXA-AS2 represses endothelium inflammation by regulating the activity of NF-κB signaling

Zhu, X., Liu, Y., Yu, J., Du, J., Guo, R., Feng, Y., Zhong, G., Jiang, Y., & Lin, J. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.012 · Cited by 43

Bromodomain and Extraterminal (BET) Protein Inhibition Suppresses Human T Cell Leukemia Virus 1 (HTLV-1) Tax Protein-mediated Tumorigenesis by Inhibiting Nuclear Factor κB (NF-κB) Signaling

Wu, X., Qi, J., Bradner, J. E., Xiao, G., & Chen, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.485029 · Cited by 45

Neutrophil Gelatinase-associated Lipocalin (NGAL) Expression Is Dependent on the Tumor-associated Sigma-2 Receptor S2RPgrmc1

Mir, S. U. R., Jin, L., & Craven, R. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324921 · Cited by 42

Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model

Schiaffino, L., Bonafede, R., Scambi, I., Parrella, E., Pizzi, M., & Mariotti, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-30659-4 · Cited by 42

Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors

Dai, Y., Chen, S., Wang, L., Pei, X., Funk, V. L., Kramer, L. B., Dent, P., & Grant, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.284216 · Cited by 42

Adiponectin protects L eydig cells against proinflammatory cytokines by suppressing the nuclear factor‐κ B signaling pathway

Wu, L., Xu, B., Fan, W., Zhu, X., Wang, G., & Zhang, A. (2013) · FEBS Journal · doi:10.1111/febs.12391 · Cited by 42

Distinct B subunits of PP 2A regulate the NF ‐κB signalling pathway through dephosphorylation of IKK β, IκBα and RelA

Tsuchiya, Y., Osaki, K., Kanamoto, M., Nakao, Y., Takahashi, E., Higuchi, T., & Kamata, H. (2017) · FEBS Letters · doi:10.1002/1873-3468.12912 · Cited by 40

Transcription Factors in Cartilage Homeostasis and Osteoarthritis

Neefjes, M., van Caam, A., & van der Kraan, P. M. (2020) · Biology · doi:10.3390/biology9090290 · Cited by 44

Transactivation of Src, PDGF receptor, and Akt is involved in IL‐1β‐induced ICAM‐1 expression in A549 cells

Lin, C., Lee, C., Chu, T., Cheng, C., Luo, S., Hsiao, L., & Yang, C. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20987 · Cited by 41

Murine Gamma Herpesvirus 68 Hijacks MAVS and IKKβ to Abrogate NFκB Activation and Antiviral Cytokine Production

Dong, X., & Feng, P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002336 · Cited by 39

IL-10 disrupts the Brd4-docking sites to inhibit LPS-induced CXCL8 and TNF-α expression in monocytes: Implications for chronic obstructive pulmonary disease

Castellucci, M., Rossato, M., Calzetti, F., Tamassia, N., Zeminian, S., Cassatella, M. A., & Bazzoni, F. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.023 · Cited by 40

Targeting Chromatin Remodeling in Inflammation and Fibrosis

Yang, J., Tian, B., & Brasier, A. R. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.11.001 · Cited by 40

Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus

Jhou, J., Chen, S.-J., Huang, H., Lin, W., Huang, D.-Y., & Tzeng, S. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.144 · Cited by 40

PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65

Paul, A., Danley, M., Saha, B., Tawfik, O. W., & Paul, S. (2015) · Scientific Reports · doi:10.1038/srep12520 · Cited by 45

Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis

Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. M. H., & Mandrup-Poulsen, T. R. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.09.014 · Cited by 37

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Chrysostomou, S., Roy, R., Prischi, F., Thamlikitkul, L., Chapman, K. L., Mufti, U., Peach, R. L., Ding, L., Hancock, D. C., Moore, C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba4627 · Cited by 39

NF-κB Inducing Kinase Regulates Intestinal Immunity and Homeostasis

Wang, B., & Shen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.895636 · Cited by 42

Regulation of Nuclear Factor κB (NF-κB) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT)

Pejanovic, N., Hochrainer, K., Liu, T., Aerne, B. L., Soares, M. P., & Anrather, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042020 · Cited by 39

Activated Apoptotic Cells Induce Dendritic Cell Maturation via Engagement of Toll-like Receptor 4 (TLR4), Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN), and β2 Integrins

Pathak, S. K., Sköld, A. E., Mohanram, V., Persson, C. M., Johansson, U., & Spetz, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336545 · Cited by 39

EVI1 Acts as an Inducible Negative-Feedback Regulator of NF-κB by Inhibiting p65 Acetylation

Xu, X., Woo, C.-H., Steere, R. R., Lee, B. C., Huang, Y., Wu, J. T., Pang, J., Lim, J. H., Xu, H., Zhang, W., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103527 · Cited by 38

Anergic CD8+ T Lymphocytes Have Impaired NF-κB Activation with Defects in p65 Phosphorylation and Acetylation

Clavijo, P. E., & Frauwirth, K. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100793 · Cited by 40

Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway

Layman, W. S., Williams, D. M., Dearman, J., Sauceda, M. A., & Zuo, J. (2015) · Cell Death Discovery · doi:10.1038/cddiscovery.2015.12 · Cited by 37

Inhibition of BRD 4 attenuates cardiomyocyte apoptosis via NF ‐κB pathway in a rat model of myocardial infarction

Sun, Y., Xie, Y., Du, L., Sun, J., & Liu, Z. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12320 · Cited by 38

Hippocampal nuclear factor kappa B accounts for stress‐induced anxiety behaviors via enhancing neuronal nitric oxide synthase ( nNOS )‐carboxy‐terminal PDZ ligand of nNOS‐Dexras1 coupling

Zhu, L., Ni, H., Chen, R., Chang, L., Shi, H., Qiu, D., Zhang, Z., Wu, D., Jiang, Z., Xin, H., et al. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14478 · Cited by 37

Lysophosphatidic Acid Induces Lymphangiogenesis and IL-8 Production in Vitro in Human Lymphatic Endothelial Cells

Mu, H. H., Calderone, T. L., Davies, M. A., Prieto, V. G., Wang, H., Mills, G. B., Bar‐Eli, M., & Gershenwald, J. E. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.03.003 · Cited by 37

Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

Álvarez, Y., Rodríguez, M. R., Municio, C., Hugo, E., Alonso, S., Ibarrola, N., Fernández, N., & Crespo, M. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391839 · Cited by 37

Epigenetic modifier trichostatin A enhanced osteogenic differentiation of mesenchymal stem cells by inhibiting NF‐κB (p65) DNA binding and promoted periodontal repair in rats

Li, Q., Liu, F., Dang, R., Feng, C., Xiao, R., Hua, Y., Wang, W., Jia, Z., & Liu, D. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29780 · Cited by 36

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Wang, P., Yang, C., Lü, J., Ren, Y., Goltzman, D., & Miao, D. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.04.003 · Cited by 35

Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-κB activation in congenital heart disease

Gu, Q., Kong, Y., Yu, Z., Li, B., & Xiao, Y. (2011) · Biochimie · doi:10.1016/j.biochi.2011.02.009 · Cited by 36

Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression

Romero, N., Waesberghe, C. V., & Favoreel, H. W. (2020) · Journal of Virology · doi:10.1128/jvi.00196-20 · Cited by 34

Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway

Tsuchiya, R., Tanaka, T., Hozumi, Y., Nakano, T., Okada, M., Topham, M. K., Iino, M., & Goto, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.11.011 · Cited by 33

Characterization of Site-Specific Phosphorylation of NF-κB p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization

Shi, H., & Berger, E. A. (2018) · Mediators of Inflammation · doi:10.1155/2018/3020675 · Cited by 33

Actin cytoskeleton differentially modulates NF-κB-mediated IL-8 expression in myelomonocytic cells

Kustermans, G., Mjiyad, N. E., Horion, J., Jacobs, N., Piette, J. G., & Legrand-Poels, S. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.08.017 · Cited by 36

Prostacyclin Inhibits IFN-γ-Stimulated Cytokine Expression by Reduced Recruitment of CBP/p300 to STAT1 in a SOCS-1-Independent Manner

Strassheim, D., Riddle, S. R., Burke, D. L., Geraci, M. W., & Stenmark, K. R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901045 · Cited by 32

Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-α-induced leukocyte–endothelial cell interaction

Ampofo, E., Rudzitis‐Auth, J., Dahmke, I. N., Rößler, O. G., Thiel, G., Montenarh, M., Menger, M. D., & Laschke, M. W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.013 · Cited by 32

Activation of NF-κB Is a Novel Target of KRAS-Induced Endometrial Carcinogenesis

Mizumoto, Y., Kyo, S., Kiyono, T., Takakura, M., Nakamura, M., Maida, Y., Mori, N., Bono, Y., Sakurai, H., & Inoue, M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2291 · Cited by 32

Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer

Börnigen, D., Tyekucheva, S., Wang, X., Rider, J. R., Lee, G. M., Mucci, L. A., Sweeney, C. J., & Huttenhower, C. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004820 · Cited by 30

NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone

Bandyopadhaya, A., Tsurumi, A., & Rahme, L. G. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01211 · Cited by 29

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

Zhao, Y., Tian, B., Sadygov, R. G., Zhang, Y., & Brasier, A. R. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.07.014 · Cited by 31

The histone deacetylase Hdac1 regulates inflammatory signalling in intestinal epithelial cells

Gonneaud, A., Gagné, J. M., Turgeon, N., & Asselin, C. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0043-2 · Cited by 32

Herpes Simplex Virus 1 UL2 Inhibits the TNF-α–Mediated NF-κB Activity by Interacting With p65/p50

Cai, M., Liao, Z., Zou, X., Xu, Z., Wang, Y., Li, T., Li, Y., Ou, X., Deng, Y., Guo, Y., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00549 · Cited by 30

The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer

Caruana, B. T., & Byrne, F. L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109688 · Cited by 31

Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition

Li, K., Zhang, Z., Mei, Y., Yang, Q., Qiao, S., Ni, C., Yao, Y., Li, X., Li, M., Wei, D., et al. (2021) · Theranostics · doi:10.7150/thno.51976 · Cited by 30

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress

Field, J. T., Martens, M. D., Mughal, W., Hai, Y., Chapman, D. C., Hatch, G. M., Ivanco, T. L., Diehl‐Jones, W. L., & Gordon, J. W. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0104-z · Cited by 30

Synergistic induction of nuclear factor-κB by transforming growth factor-β and tumour necrosis factor-α is mediated by protein kinase A-dependent RelA acetylation

Ishinaga, H., Jono, H., Lim, J. H., Komatsu, K., Xu, X., Lee, J., Woo, C.-H., Xu, H., Feng, X., Chen, L., et al. (2008) · Biochemical Journal · doi:10.1042/bj20080781 · Cited by 29

GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation

Yang, Y., Song, S., Li, S., Kang, J., Li, Y., Zhao, N., Ye, D., Qin, F., Du, Y., Sun, J., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06656-z · Cited by 29

NFκB function and regulation in cutaneous T-cell lymphoma.

Chang, T., & Vancurova, I. (2013) · Europe PMC (PubMed Central) · Cited by 28

HDAC6-Selective Inhibitor Overcomes Bortezomib Resistance in Multiple Myeloma

Lee, S. W., Yeon, S.-K., Kim, G. W., Lee, D. H., Jeon, Y. H., Yoo, J. H., Kim, S. Y., & Kwon, S. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031341 · Cited by 28

Zn2+-induced NF-κB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation

Kim, Y.-M., Cao, D., REED, W. A., Wu, W., Jaspers, I., Tal, T. L., Bromberg, P. A., & Samet, J. M. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.08.003 · Cited by 28

NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression

Tanaka, T., Hozumi, Y., Iino, M., & Goto, K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.06.021 · Cited by 24

Spinal NF-kB upregulation contributes to hyperalgesia in a rat model of advanced osteoarthritis

Li, Y., Yang, Y., Guo, J., Guo, X., Feng, Z., & Zhao, X. (2020) · Molecular Pain · doi:10.1177/1744806920905691 · Cited by 27

Merkel Cell Polyomavirus Small T Antigen Activates Noncanonical NF-κB Signaling to Promote Tumorigenesis

Zhao, J., Jia, Y., Shen, S., Kim, J., Wang, X., Lee, E., Brownell, I., Cho‐Vega, J. H., Lewis, C. M., Homsi, J., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0587 · Cited by 30

IKKε modulates RSV-induced NF-κB-dependent gene transcription

Bao, X., Indukuri, H., Liu, T., Liao, S., Tian, B., Brasier, A. R., Garofalo, R. P., & Casola, A. (2010) · Virology · doi:10.1016/j.virol.2010.09.016 · Cited by 26

Role of dietary antioxidants in human metapneumovirus infection

Komaravelli, N., Kelley, J. P., Garofalo, M. P., Wu, H., Casola, A., & Kolli, D. (2015) · Virus Research · doi:10.1016/j.virusres.2015.01.018 · Cited by 26

Unconventional Role of the Inwardly Rectifying Potassium Channel Kir2.2 as a Constitutive Activator of RelA in Cancer

Lee, I., Lee, S.-J., Kang, T. M., Kang, W. K., & Park, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2498 · Cited by 26

DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model

Luo, X. M., He, Z., Sun, X., Gu, X., Zhang, W., Gao, J., Li, X., Jia, R., Wei, J., Yu, Y., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s232279 · Cited by 25

RAB7A Regulates Vimentin Phosphorylation through AKT and PAK

Romanò, R., Calcagnile, M., Margiotta, A., Franci, L., Chiariello, M., Alifano, P., & Bucci, C. (2021) · Cancers · doi:10.3390/cancers13092220 · Cited by 25

DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9

Aman, S., Li, Y., Cheng, Y., Yang, Y., Lv, L., Li, B., Xia, K., Li, S., & Wu, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00733-4 · Cited by 25

Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification

Basu, S., Pathak, S., Pathak, S. K., Bhattacharyya, A., Banerjee, A., Kundu, M., & Basu, J. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00997.x · Cited by 25

Mycophenolic acid attenuates tumor necrosis factor-α-induced endothelin-1 production in human aortic endothelial cells

Yang, W. S., Lee, J. M., Han, N. J., Kim, Y. J., Chang, J. W., & Park, S.-K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.018 · Cited by 25

Effect of Iron Deficiency on a Murine Model of Smoke-induced Emphysema

Sato, K., Inoue, S., Igarashi, A., Tokairin, Y., Yamauchi, K., Kimura, T., Nishiwaki, M., Nemoto, T., Nakano, H., Sato, M., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0239oc · Cited by 25

Histone Acetyltransferase p300 Acetylates Pax5 and Strongly Enhances Pax5-mediated Transcriptional Activity

He, T., Hong, S. Y., Huang, L., Xue, W., Yu, Z., Kwon, H., Kirk, M., Ding, S., Su, K., & Zhang, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.176289 · Cited by 24

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils

Stevens, M. G. H., Poucke, M. V., Peelman, L. J., Rainard, P., Spiegeleer, B. M. J. D., Rogiers, C., de Walle, G. R. V., Duchateau, L., & Burvenich, C. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3358 · Cited by 24

Neutral sphingomyelinase inhibition alleviates apoptosis, but not ER stress, in liver ischemia–reperfusion injury

Tuzcu, H., Ünal, B., Kıraç, E., Konuk, E., Özcan, F., Elpek, G. Ö., Demır, N., & Aslan, M. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1298103 · Cited by 24

RelA is required for IL-1β stimulation of Matrix Metalloproteinase-1 expression in chondrocytes

Raymond, L., Eck, S., Hays, E., Tomek, I. M., Kantor, S., & Vincenti, M. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.09.011 · Cited by 24

Comprehensive lung injury pathology induced by mTOR inhibitors

Aparicio, G., Blanco, M., Médina, V., Fernández, O., Jiménez, P., Lema, M., Figueroa, A., & Aparicio, L. M. A. (2009) · Clinical & Translational Oncology · doi:10.1007/s12094-009-0394-y · Cited by 25

Protein kinase D3 promotes gastric cancer development through p65/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 activation of glycolysis

Zhang, J., Zhang, Y., Wang, J., Zhang, S.-S., Zhao, Y., Ren, H., Chu, Y., Feng, L., & Wang, C. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.04.022 · Cited by 23

High Throughput Short Interfering RNA (siRNA) Screening of the Human Kinome Identifies Novel Kinases Controlling the Canonical Nuclear Factor-κB (NF-κB) Activation Pathway

Choudhary, S., Rosenblatt, K. P., Fang, L., Tian, B., Wu, Z.-H., & Brasier, A. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.224923 · Cited by 23

Thr435 phosphorylation regulates RelA (p65) NF-κB subunit transactivation

O'Shea, J. M., & Perkins, N. D. (2009) · Biochemical Journal · doi:10.1042/bj20091630 · Cited by 24

The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes

Diamant, G., Bahat, A., & Dikstein, R. (2016) · Nature Communications · doi:10.1038/ncomms11547 · Cited by 23

Regulation of NF-κB responses by epigenetic suppression of IκBα expression in HCT116 intestinal epithelial cells

O'Gorman, A., Colleran, A., Ryan, A. E., Mann, J., & Egan, L. J. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00460.2009 · Cited by 23

The NF-κB Nucleolar Stress Response Pathway

Thoms, H. C., & Stark, L. A. (2021) · Biomedicines · doi:10.3390/biomedicines9091082 · Cited by 24

Activation of Aryl Hydrocarbon Receptor Negatively Regulates Thymic Stromal Lymphopoietin Gene Expression via Protein Kinase Cδ-p300–NF-κB Pathway in Keratinocytes under Inflammatory Conditions

Jeong, H., Shin, J. Y., Kim, M., Na, J., & Ju, B. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.012 · Cited by 22

Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors

Martin, R., Sun, Y., MacKinnon, S., Cuccia, L., Pagé, V., Hébert, T. E., & Tanny, J. C. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00048-20 · Cited by 22

Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt

Kim, J. K., Han, N. R., Park, S. M., Jegal, K. H., Jung, J. Y., Jung, E. H., Kim, E. O., Kim, D., Jung, D. H., Lee, J. R., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.111044 · Cited by 22

Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65

Liu, Q., Zhang, Z., Zheng, Z., Zheng, C., Liu, Y., Hu, Q., Ke, X., & Wang, H. (2016) · Scientific Reports · doi:10.1038/srep28481 · Cited by 21

Restoration of GATA4 expression impedes breast cancer progression by transcriptional repression of ReLA and inhibition of NF‐κB signaling

Han, X., Tang, J., Chen, T., & Ren, G. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27455 · Cited by 21

Inhibitory effects of aurentiacin from Syzygium samarangense on lipopolysaccharide-induced inflammatory response in mouse macrophages

Kim, Y., Kim, H., Ko, H., Amor, E. C., Lee, J. W., & Yang, H. O. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.050 · Cited by 21

Nuclear Factor-κB Dimer Exchange Promotes a p21waf1/cip1 Superinduction Response in Human T Leukemic Cells

Chang, P.-Y., & Miyamoto, S. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0259 · Cited by 21

Elevated Osteopontin Levels in Metastatic Melanoma Correlate with Epigenetic Silencing of Breast Cancer Metastasis Suppressor 1

Metge, B. J., Liu, S., Riker, A. I., Fodstad, Ø., Samant, R. S., & Shevde, L. A. (2010) · Oncology · doi:10.1159/000292363 · Cited by 20

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

Agnati, L. F., Guidolin, D., Leo, G., Guescini, M., Pizzi, M., Stocchi, V., Spano, P., Ghidoni, R., Ciruela, F., Genedani, S., et al. (2011) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2011.599393 · Cited by 20

Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells

Chuang, T., Rehan, A., & Khorram, O. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.12.002 · Cited by 20

Regulation of NF-κB, FHC and SOD2 in response to oxidative stress in the freeze tolerant wood frog, Rana sylvatica

Gupta, A., Brooks, C., & Storey, K. B. (2020) · Cryobiology · doi:10.1016/j.cryobiol.2020.10.012 · Cited by 19

Hypo‐phosphorylation leads to nuclear retention of NF‐κB p65 due to impaired IκBα gene synthesis

Hochrainer, K., Racchumi, G., & Anrather, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.056 · Cited by 20

Histone Deacetylase Inhibitor Trichostatin A Sustains Sodium Pervanadate-induced NF-κB Activation by Delaying IκBα mRNA Resynthesis

Horion, J., Gloire, G., Mjiyad, N. E., Quivy, V., Vermeulen, L., Berghe, W. V., Haegeman, G., Lint, C. M. V., Piette, J. G., & Habraken, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609166200 · Cited by 20

Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer

Hermida‐Prado, F., Xie, Y., Sherman, S., Nagy, Z., Russo, D., Akhshi, T. K., Chu, Z., Feit, A. S., Campisi, M., Chen, M., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1711 · Cited by 19

Transitional B Cells Exhibit a B Cell Receptor-Specific Nuclear Defect in Gene Transcription

Andrews, S. F., & Rawlings, D. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802368 · Cited by 19

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation

Furrer, A., Hottiger, M. O., & Valaperti, A. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.04.009 · Cited by 19

Effects of diesel exhaust particles on the condition of mouse ocular surface

Yang, Q., Tang, L., Shen, M., Wang, Y., Wei, Y. L., Jeyalatha, M. V., Chen, P., Dong, F., Wang, G., Wu, S.-P., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.07.101 · Cited by 19

Nuclear Translocation of p65 is Controlled by Sec6 via the Degradation of IκBα

Tanaka, T., & Iino, M. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25122 · Cited by 20

NF-κB Activation Coordinated by IKKβ and IKKε Enables Latent Infection of Kaposi's Sarcoma-Associated Herpesvirus

He, Z., Zhao, J., Zhang, J., Jung, J. U., & Feng, P. (2013) · Journal of Virology · doi:10.1128/jvi.01716-13 · Cited by 19

Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer

Buensuceso, A. V., Fritz, J. L., Collins, O. M., Valdés, Y. R., Borrelli, M. J., DiMattia, G. E., & Shepherd, T. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-06796-2 · Cited by 18

Caveolin-1 suppresses Human Immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB

Simmons, G. E., Jr., Taylor, H. E., & Hildreth, J. E. K. (2012) · Virology · doi:10.1016/j.virol.2012.05.016 · Cited by 18

Dexamethasone-induced Intra-Uterine Growth Restriction impacts NOSTRIN and its downstream effector genes in the rat mesometrial uterus

Chakraborty, S., Islam, S., Saha, S., & Ain, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-26590-3 · Cited by 18

The development of immune-modulating compounds to disrupt HIV latency

Remoli, A. L., Marsili, G., Battistini, A., & Sgarbanti, M. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.05.003 · Cited by 18

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB

Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827

NF-kappaB RelA phosphorylation regulates RelA acetylation

Chen, L.-F., Williams, S. A., Mu, Y., Duerr, J. M., Buckbinder, L., Greene, C., Acetylation, R., Chen, L.-F., Williams, S. A., Mu, Y., et al. (2013)

Phosphorylation, acetylation and methylation modification and the biological activity regulation of nuclear transcription factor NF-κB/RelA

Wang, L. (2012)

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB

Yang, X., Tajkhorshid, E., & Chen, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-09 · Cited by 149

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65

Buerki, C., Rothgiesser, K., Valovka, T., Owen, H. R., Rehrauer, H., Fey, M., Lane, W. S., & Hottiger, M. O. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn003 · Cited by 116