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Cited by 190

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

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Takahashi, Yoshinori, Karbowski, Mariusz, Yamaguchi, Hirohito, Kazi, Aslamuzzaman, Wu, Jie, Sebti, Saïd M., Youle, Richard J., Wang, Hong-Gang·2005·Molecular and Cellular Biology
DOI 10.1128/mcb.25.21.9369-9382.2005
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Abstract

Bif-1, a member of the endophilin B protein family, interacts with Bax and promotes interleukin-3 withdrawal-induced Bax conformational change and apoptosis when overexpressed in FL5.12 cells. Here, we provide evidence that Bif-1 plays a regulatory role in apoptotic activation of not only Bax but also Bak and appears to be involved in suppression of tumorigenesis. Inhibition of endogenous Bif-1 expression in HeLa cells by RNA interference abrogated the conformational change of Bax and Bak, cytochrome c release, and caspase 3 activation induced by various intrinsic death signals. Similar results were obtained in Bif-1 knockout mouse embryonic fibroblasts. While Bif-1 did not directly interact with Bak, it heterodimerized with Bax on mitochondria in intact cells, and this interaction was enhanced by apoptosis induction and preceded the Bax conformational change. Moreover, suppression of Bif-1 expression was associated with an enhanced ability of HeLa cells to form colonies in soft agar and tumors in nude mice. Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis.

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Metadata

Authors
Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S. M., Youle, R. J., & Wang, H.-G.
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
2005-11-01
Volume
25
Issue
21
Pages
9369-9382
ISSN
  • 0270-7306 (ISSN-L)
  • 1098-5549
DOI
10.1128/mcb.25.21.9369-9382.2005
OpenAlex
W2162378963
Cited by
190
References
8
FWCI
6.22
Type
journal article
Language
en
Open access
green
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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CoChat. (2026). Citation check: Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis. https://app.cochat.ai/papers/10.1128/mcb.25.21.9369-9382.2005
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Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S. M., Youle, R. J., & Wang, H.-G. (2005). Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.25.21.9369-9382.2005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.