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Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model
Open accessAbstract
The expression of the phase 2 detoxification enzymes and antioxidant proteins is induced at the transcriptional level by Nrf2 and negatively regulated at the posttranslational level by Keap1 through protein-protein interactions with and subsequent proteolysis of Nrf2. We found that the Neh2 domain of Nrf2 is an intrinsically disordered but biologically active regulatory domain containing a 33-residue central alpha-helix followed by a mini antiparallel beta-sheet. Isothermal calorimetry analysis indicated that one Neh2 molecule interacts with two molecules of Keap1 via two binding sites, the stronger binding ETGE motif and the weaker binding DLG motif. Nuclear magnetic resonance titration study showed that these two motifs of the Neh2 domain bind to an overlapping site on the bottom surface of the beta-propeller structure of Keap1. In contrast, the central alpha-helix of the Neh2 domain does not have any observable affinity to Keap1, suggesting that this region may serve as a bridge connecting the two motifs for the association with the two beta-propeller structures of a dimer of Keap1. Based on these observations, we propose that Keap1 recruits Nrf2 by the ETGE motif and that the DLG motif of the Neh2 domain locks its lysine-rich central alpha-helix in a correct position to benefit ubiquitin signaling.
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“Keap1 recruits Nrf2 first through the binding of one Keap1 molecule to the high-affinity ETGE motif within the Nrf2’s Neh2 domain. Subsequent binding of the other Keap1 molecule at the low-affinity DLG motif locks Nrf2 in place by orienting the lysine residues within Neh2 in the correct position for ubiquitination by Cul3 and degradation by the 26S proteasome [58,65].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [58]
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“Keap1 Recruits Neh2 Through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model.”
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SKIN REDOX BALANCE MAINTENANCE: THE NEED FOR AN NRF2- ACTIVATORS DELIVERY SYSTEM
Greenwald, M. B., Sasson, S. B., Peled, H., & Kohen, R. (2016) · doi:10.18143/jisanh_v3i3_1457
“According to the hinge and latch model, Keap1 homodimer binds to Nrf2 in two binding sites within the Neh2 domain of Nrf2 (termed ETGE and DLG motifs) possessing high (ETGE) and low (DLG) affinity, enabling an optimal setting of lysine residues for ubiquitin conjugation [208–210].”
BackgroundRamkissoon, A. (2012) · TSpace (University of Toronto)
Nrf2: A Candidate Therapeutic Target to Dampen Oxidative Stress in Acute Myocardial Infarction
Maltagliati, A. J. (2016) · UA Campus Repository (The University of Arizona)
Ranea‐Robles, P. (2017) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Protection, adaptation or cell death as response to toxins
Sthijns, M. M. J. P. E. (2017) · doi:10.26481/dis.20170915ms
CHD6 and the oxidative stress-induced DNA damage response
Moore, S. (2018) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/32051
Bonora, N. (2018) · Gredos (University of Salamanca) · doi:10.14201/gredos.137569
Clementino, M. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.047
“Constitutive activation of Nrf2 has been identified in several types of 8 human cancer cell lines and tumors (Lau et al. 2013; Ohta et al. 2008; Sporn and Liby 2012; Tong et al. 2006).”
BackgroundAAV-Nrf2 Mediated Rescue of Oxidative Stress in Mouse Models
Liang, K. J. (2015) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tmc2-r921
Investigation of renal ischemia-reperfusion induced liver injury
Shang, Y. (2018) · Mspace (University of Manitoba)
Paul, M., Misra, S., Patra, G., Datta, S., Saha, B., & Mukhopadhyay, S. (2021) · Lecture notes in bioengineering · doi:10.1007/978-981-33-6915-3_55
Marrone, G. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Faculty Opinions recommendation of Transcriptional regulation by nrf2.
Ji, L. L. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731119952.793582094
Metadata
- Authors
- Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Tanaka, Toshiyuki
- Yamamoto, Masayuki
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-04-01
- Volume
- 26
- Issue
- 8
- Pages
- 2887-2900
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1446969
- OpenAlex
- W2171218310
- Cited by
- 759
- References
- 71
- Citations by year
- 2026: 44 · 2025: 44 · 2024: 42 · 2023: 56 · 2022: 58 · 2021: 46 · 2020: 59 · 2019: 41 · 2018: 38 · 2017: 51 · 2016: 31 · 2015: 34 · 2014: 36 · 2013: 35 · 2012: 30
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- Keap1, Nrf2, protein-protein interaction, two-site model, beta-propeller, intrinsically disordered proteins, ubiquitin ligase, post-translational regulation, antioxidant proteins
- MeSH terms
- Kelch-Like ECH-Associated Protein 1, Amino Acid Sequence, Animals, Binding Sites, Calorimetry, Cytoskeletal Proteins, Escherichia coli, Models, Chemical, Models, Molecular, Molecular Sequence Data, Protein Binding, Protein Processing, Post-Translational, Recombinant Fusion Proteins, Thermodynamics, Ultracentrifugation, Conserved Sequence, Point Mutation, Sequence Homology, Amino Acid, Protein Structure, Secondary, Protein Structure, Tertiary, Nuclear Magnetic Resonance, Biomolecular, Amino Acid Motifs, Adaptor Proteins, Signal Transducing, NF-E2-Related Factor 2, Mice
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