Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

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2. Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?
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3. Nrf2: control of sensitivity to carcinogens
   Stephen L. Slocum, Thomas W. Kensler · 2011 · Archives of Toxicology
4. Somatic mutations of the KEAP1 gene in common solid cancers
   Nam Jin Yoo, Hyung Ran Kim, Yoo Ri Kim, Chang Hyeok An, Sug Hyung Lee · 2012 · Histopathology
5. A systems biology perspective on Nrf2-mediated antioxidant response
   Qiang Zhang, Jingbo Pi, Courtney Georgette Woods, Melvin E. Andersen · 2009 · Toxicology and Applied Pharmacology
6. Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging
   Sarah J. Chapple, Richard C. M. Siow, Giovanni E. Mann · 2012 · The International Journal of Biochemistry & Cell Biology
7. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
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8. Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids
   Emilia Kansanen, Henna-Kaisa Jyrkkänen, Anna–Liisa Levonen · 2011 · Free Radical Biology and Medicine
9. Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases
   Mathew George, Matthan Tharakan, John W. Culberson, Arubala P. Reddy, P. Hemachandra Reddy · 2022 · Ageing Research Reviews
10. Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism
    Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo et al. · 2011 · Journal of Biological Chemistry
11. Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1
    Hye‐Kyung Na, Young‐Joon Surh · 2013 · Free Radical Biology and Medicine
12. Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites
    Juma Hoshino, Eun‐Jung Park, Tamara P. Kondratyuk, Laura Marler, John Michael Pezzuto, Richard Bruce van Breemen, Shunyan Mo, Yongchao Li, Mark Cushman · 2010 · Journal of Medicinal Chemistry
13. Oncogenic functions of the transcription factor Nrf2
    Irene Gañán‐Gómez, Yue Wei, Hui Yang, M. C. Boyano-Adánez, Guillermo Garcia‐Manero · 2013 · Free Radical Biology and Medicine
14. Role of Nrf2 in protection against acute kidney injury
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15. Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
    Leonard D. Goldstein, James Lee, Florian Gnad, Christiaan N. Klijn, Annalisa Schaub, Jens Reeder, Anneleen Daemen, Corey E. Bakalarski, Thomas Holcomb, David S. Shames et al. · 2016 · Cell Reports
16. The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
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17. Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
    Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova‐Kostova, Takuma Kasai, Takashi Kamei et al. · 2021 · Communications Biology
18. Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?
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19. PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
    Jianglin Ma, Hong Cai, Tongde Wu, Bijan Sobhian, Yanying Huo, Allen L. Alcivar, Monal Mehta, Ka Lung Cheung, Shridar Ganesan, Ah‐Ng Tony Kong et al. · 2012 · Molecular and Cellular Biology
20. Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammation
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21. Redox toxicology of environmental chemicals causing oxidative stress
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22. Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals
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23. The Nrf2 Pathway in Liver Diseases
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24. The Keap1–Nrf2 system as an in vivo sensor for electrophiles
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25. NRF2: KEAPing Tumors Protected
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26. Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory
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27. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
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28. The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?
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29. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
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30. Comparison of Secondary Structure Formation Using 10 Different Force Fields in Microsecond Molecular Dynamics Simulations
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31. Potential Applications of NRF2 Inhibitors in Cancer Therapy
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32. The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
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33. The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
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34. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
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35. Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling
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36. The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?
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37. Keap Calm, and Carry on Covalently
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38. Monitoring Keap1–Nrf2 interactions in single live cells
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39. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
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40. Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges
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41. Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion
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42. Potential Applications of NRF2 Modulators in Cancer Therapy
    Emiliano Panieri, Aleksandra Buha Djordjević, Pelin Telkoparan‐Akillilar, Dilek Cevik, Demetrios Kouretas, Aristidis S. Veskoukis, Zoi Skaperda, Aristidis Michael Tsatsakis, David Wallace, Síbel Süzen et al. · 2020 · Antioxidants
43. The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases
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44. The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
    Moon-Young Song, Da-Young Lee, Kyung‐Soo Chun, Eun‐Hee Kim · 2021 · International Journal of Molecular Sciences
45. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
    Zhu, Jiayu, Wang, Huihui, Chen, Feng, Fu, Jingqi, Xu, Yuanyuan, Hou, Yongyong, Kou, Henry H., Zhai, Cheng, Nelson, M. Bud, Zhang, Qiang et al. · 2016 · Free Radical Biology and Medicine
46. Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease
    Bo-Hyun Choi, Kyung-Shin Kang, Mi‐Kyoung Kwak · 2014 · Molecules
47. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
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48. Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search
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49. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation
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50. Cysteine-based regulation of the CUL3 adaptor protein Keap1
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51. The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response
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52. Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection
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53. Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2
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54. Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction
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55. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
    Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez‐Nievas, Hélène Charlotte Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé et al. · 2017 · PLoS Genetics
56. A catalogue of somatic NRF2 gain-of-function mutations in cancer
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57. Arsenic‐Mediated Activation of the Nrf2‐Keap1 Antioxidant Pathway
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58. Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
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59. Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
    Hast, Bridgid E., Cloer, Erica W., Goldfarb, Dennis, Li, Heng, Siesser, Priscila F., Yan, Feng, Walter, Vonn, Zheng, Ning, Hayes, D. Neil, Major, Michael B. · 2014 · Cancer Research
60. Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage
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61. Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
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62. Subcellular localization and cytoplasmic complex status of endogenous Keap1
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63. Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles
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64. The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
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65. Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy
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66. The mutational landscape of hepatocellular carcinoma
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67. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath
    Ana Isabel Rojo, Patricia Rada, Javier Egea, Angelo Oscar Rosa, Manuela G. López, Antonio Cuadrado · 2008 · Molecular and Cellular Neuroscience
68. Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance
    In-geun Ryoo, Sang-hwan Lee, Mi-Kyoung Kwak · 2015 · Oxidative Medicine and Cellular Longevity
69. Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy
    Temitope Isaac Adelusi, Lei Du, Hao Meng, Xueyan Zhou, Xuan Qian, Apu Chowdhury, Ying Sun, Qian Lü, Xiaoxing Yin · 2020 · Biomedicine & Pharmacotherapy
70. Nrf2 Activators Attenuate the Progression of Nonalcoholic Steatohepatitis–Related Fibrosis in a Dietary Rat Model
    Rieko Shimozono, Yoshiji Asaoka, Yoshitaka Yoshizawa, Takumi Aoki, Hidetoshi Noda, Masateru Yamada, Mie Kaino, Hidenori Mochizuki · 2013 · Molecular Pharmacology
71. Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
    Nathan D. Camp, Richard G. James, David W. Dawson, Feng Yan, James M. Davison, Scott A. Houck, Xiaobo Tang, Ning Zheng, Michael B. Major, Randall T. Moon · 2012 · Journal of Biological Chemistry
72. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
    Tatsuro Iso, Takafumi Suzuki, Liam Baird, Masayuki P. Yamamoto · 2016 · Molecular and Cellular Biology
73. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
    Jiancheng Wang, Qiying Lu, Jianye Cai, Yi Wang, Xiaofan Lai, Yuan Qiu, Yinong Huang, Qiong Ke, Yanan Zhang, Yuanjun Guan et al. · 2019 · Nature Communications
74. NRF2, cancer and calorie restriction
    Alejandro Martín‐Montalvo, José M. Villalba, Plácido Navas, Rafael de Cabo · 2010 · Oncogene
75. Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
    Yoshinobu Ichimura, Masaaki Komatsu · 2018 · Frontiers in Oncology
76. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
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77. Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
    Akhileshwar Namani, Yulong Li, Xiu Jun Wang, Xiuwen Tang · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
78. Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions
    Zhengyu Jiang, Mengchen Lu, Qidong You · 2016 · Journal of Medicinal Chemistry
79. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
    Yiguo Zhang, Dorothy H. Crouch, Masayuki P. Yamamoto, John D. Hayes · 2006 · Biochemical Journal
80. Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction
    Hélène Charlotte Bertrand, Marjolein Schaap, Liam Baird, Nikolaos Georgakopoulos, Adrian Fowkes, Clarisse Thiollier, Hiroko Kaatchi, Albena T. Dinkova‐Kostova, Geoffrey Wells · 2015 · Journal of Medicinal Chemistry
81. Role of NRF2 in Lung Cancer
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82. The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway
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83. Protective Role of Nrf2 in Renal Disease
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84. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
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85. The Keap1–Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1
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86. Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE/TFAM signaling in diabetic kidney disease
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87. The role of natural products in revealing NRF2 function
    Donna D. Zhang, Eli Chapman · 2020 · Natural Product Reports
88. Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes
    M. He, Richard C. M. Siow, D. Sugden, Ling Gao, X. Cheng, Giovanni E. Mann · 2010 · Nutrition Metabolism and Cardiovascular Diseases
89. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
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90. Keap1 as the redox sensor of the antioxidant response
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91. Kavalactones Protect Neural Cells against Amyloid β Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation
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92. Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
    Cui Rong Zhao, Zu Hua Gao, Xian Jun Qu · 2010 · Cancer Epidemiology
93. An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
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94. WDR23 regulates NRF2 independently of KEAP1
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95. Molecular Evolution of Keap1
    Li Li, Makoto Kobayashi, Hiroshi Kaneko, Yaeko Nakajima‐Takagi, Yuko Nakayama, Masayuki P. Yamamoto · 2007 · Journal of Biological Chemistry
96. Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
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97. The KEAP1-NRF2 System and Neurodegenerative Diseases
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98. Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL
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99. Proteins as binding targets of isothiocyanates in cancer prevention
    L. Mi, Anthony J. Di Pasqua, Fung‐Lung Chung · 2011 · Carcinogenesis
100. A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
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