Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Kumar, Vishal; Kundu, Satyabrata; Singh, Arti; Singh, Shamsher

doi:10.2174/1570159x19666210609160017

Cited by 210Histone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatmentsSirtuins and Resveratrol in Medicine

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

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Kumar, Vishal, Kundu, Satyabrata, Singh, Arti, Singh, Shamsher·2022·Current Neuropharmacology

DOI 10.2174/1570159x19666210609160017PMC PMC9199543

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Abstract

Neurodegenerative diseases are a group of pathological conditions that cause motor incordination (jerking movements), cognitive and memory impairments result from degeneration of neurons in a specific area of the brain. Oxidative stress, mitochondrial dysfunction, excitotoxicity, neuroinflammation, neurochemical imbalance and histone deacetylase enzymes (HDAC) are known to play a crucial role in neurodegeneration. HDAC is classified into four categories (class I, II, III and class IV) depending upon their location and functions. HDAC1 and 2 are involved in neurodegeneration, while HDAC3-11 and class III HDACs are beneficial as neuroprotective. HDACs are localized in different parts of the brain- HDAC1 (hippocampus and cortex), HDAC2 (nucleus), HDAC3, 4, 5, 7 and 9 (nucleus and cytoplasm), HDAC6 & HDAC7 (cytoplasm) and HDAC11 (Nucleus, cornus ammonis 1 and spinal cord). In pathological conditions, HDAC up-regulates glutamate, phosphorylation of tau, and glial fibrillary acidic proteins while down-regulating BDNF, Heat shock protein 70 and Gelsolin. Class III HDACs are divided into seven sub-classes (SIRT1-SIRT7). Sirtuins are localized in the different parts of the brain and neuron -Sirt1 (nucleus), Sirt2 (cortex, striatum, hippocampus and spinal cord), Sirt3 (mitochondria and cytoplasm), Sirt4, Sirt5 & Sirt6 (mitochondria), Sirt7 (nucleus) and Sirt8 (nucleolus). SIRTs (1, 3, 4, and 6) are involved in neuronal survival, proliferation and modulating stress response, and SIRT2 is associated with Parkinsonism, Huntington's disease and Alzheimer's disease, whereas SIRT6 is only associated with Alzheimer's disease. In this critical review, we have discussed the mechanisms and therapeutic targets of HDACs that would be beneficial for the management of neurodegenerative disorders.

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HDAC inhibitors often display limited isoform selectivity and off-target activity.
“HDAC inhibitors often display limited isoform selectivity and off-target activity, which constrains their translational potential in the nervous system (Kumar et al., 2022).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Kumar et al., 2022
The Conclusion (page unavailable) identifies lack of specificity and isoform selectivity as problems for HDAC inhibitors and says improving specificity may improve their effectiveness. It raises concern about *limited knowledge* of off-target specificity, but does not establish that HDAC inhibitors often have off-target activity. (LLM, conf=0.83)
Experimental — accuracy not yet measured
HDAC6 is a predominantly cytoplasmic deacetylase that regulates microtubule dynamics and autophagic flux.
“HDAC6, a predominantly cytoplasmic deacetylase, regulates microtubule dynamics and autophagic flux (Kumar et al., 2022).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Kumar et al., 2022
The Class IIb HDACs section (page unavailable) calls HDAC6 the main cytoplasmic deacetylase and reports that it is required for autophagic degradation of aggregated huntingtin. The HDAC6 section (page unavailable) says it deacetylates tubulin, but does not explicitly establish regulation of microtubule dynamics; the autophagy finding is also narrower than a general claim about autophagic flux. (LLM, conf=0.83)
Experimental — accuracy not yet measured
HDAC inhibitors can enhance histone acetylation and ameliorate cognitive impairments in various AD models.
“HDAC inhibitors can enhance histone acetylation and ameliorate cognitive impairments in various AD models, and HDAC inhibition has been recognized as an attractive therapeutic strategy for AD [4, 5, 7].”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [7]
The Alzheimer’s Disease section (page unavailable) reports that mice treated with a selective HDAC3 inhibitor had increased histone acetylation and cognition; it also reports improved memory in an AD mouse after HDAC2 knockdown. It does not establish that HDAC inhibitors produced both effects across various AD models: the HDAC2 result involves knockdown, not inhibitor treatment. (LLM, conf=0.83)
Experimental — accuracy not yet measured
HDAC inhibitors demonstrate anti-inflammatory and neuroprotective effects in neurodegenerative models by dampening inflammatory signaling and supporting synaptic and cognitive function.
“HDAC inhibitors also demonstrate anti-inflammatory and neuroprotective effects in neurodegenerative models by dampening inflammatory signaling and supporting synaptic and cognitive function (Morrison et al., 2006; Zhou et al., 2018; Kumar et al., 2022).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Kumar et al., 2022
Aberrant HDAC3 expression increases neuronal vulnerability.
“while aberrant HDAC3 expression increases neuronal vulnerability (Kumar et al., 2022)”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Kumar et al., 2022

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“Mutation in the SMN1 gene (survival motor neuron-1) causes fatal motor neuron and autosomal recessive disease by the duplication of SMN locus and SMN2 gene (SMN2), however, SMN1 is also coded by the SMN protein [48].”
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[129]Szegő É.M. Outeiro T.F. Kazantsev A.G. Sirtuins in brain and neurodegenerative disease. Introductory Review on Sirtuins in Biology, Aging, and Disease. Elsevier 2018 175 195
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Authors: Kumar, V., Kundu, S., Singh, A., & Singh, S.
Affiliations: Indo Soviet Friendship College of Pharmacy (IN)
Corresponding author: Singh, Shamsher
ORCID: Kumar, Vishal
Kundu, Satyabrata
Singh, Arti
Singh, Shamsher
Venue: Current Neuropharmacology
Publisher: Bentham Science Publishers Ltd.
Published: 2022-01
Volume: 20
Issue: 1
Pages: 158-178
ISSN: 1570-159X (ISSN-L)
DOI: 10.2174/1570159x19666210609160017
PMC: PMC9199543
OpenAlex: W3174079095
Cited by: 210
References: 185
Citations by year: 2026: 46 · 2025: 60 · 2024: 54 · 2023: 35 · 2022: 14 · 2021: 1
FWCI: 2.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc
Locations: Current Neuropharmacology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: histone deacetylase, histone deacetylase inhibitors, neurodegenerative diseases, class I HDACs, class II HDACs, sirtuins, SIRT1, SIRT2, SIRT6, neuroprotection, Alzheimer's disease, Parkinson's disease, Huntington's disease, oxidative stress, neuroinflammation, mitochondrial dysfunction, excitotoxicity, brain-derived neurotrophic factor, tau phosphorylation, glial fibrillary acidic protein
MeSH terms: Neuroinflammatory Diseases, Brain, Histone Deacetylases, Humans, Neurodegenerative Diseases, Sirtuins

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Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

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