The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Macrophage Proresolving Mediators—the When and Where
Open accessAbstract
Macrophages and neutrophils orchestrate acute inflammation and host defense as well as the resolution phase and return to homeostasis. In this article, we review the contribution of macrophages to local lipid mediator (LM) levels and the regulation of macrophage LM profiles by polymorphonuclear neutrophils and neutrophil-derived microparticles. We carried out LM metabololipidomics, profiling distinct phagocytes: neutrophils (PMNs), apoptotic PMNs, and macrophages. Efferocytosis increased specialized proresolving mediator (SPM) biosynthesis, including resolvin D1 (RvD1), RvD2, and RvE2, which were further elevated by PMN microparticles. In studies using deuterium-labeled precursors ( d 8 -arachidonic acid, d 5 -eicosapentaenoic acid, and d 5 -docosahexaenoic acid), apoptotic PMNs and microparticles contributed to SPM biosynthesis during efferocytosis. Assessment of macrophage LM profiles in M2 macrophages demonstrated higher SPM levels in this macrophage subset, including maresin 1 (MaR1), and lower amounts of leukotriene B 4 (LTB 4 ) and prostaglandins than in M1. Apoptotic PMN uptake by both macrophage subtypes led to modulation of their LM profiles. LTB 4 was downregulated in M2, whereas SPMs including lipoxin A 4 were increased. Conversely, uptake of apoptotic PMNs by M2 macrophages reduced (∼25%) overall LMs. MaR1 displays potent tissue-regenerative and antinociceptive actions in addition to its proresolving and anti-inflammatory actions. In addition, the MaR1 biosynthetic intermediate 13 S ,14 S -epoxy-maresin is also bioactive, inhibiting LTB 4 biosynthesis and switching macrophage phenotypes from M1 to M2. Together, these results establish LM signature profiles of human phagocytes and related subpopulations. They demonstrate microparticle regulation of macrophage-specific endogenous LMs during defined stages of acute inflammation and their dynamic changes in human primary phagocytes.
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“In addition, SPM biosynthesis is higher in M2-like macrophages than in M1-like macrophages and increases further in response to efferocytosis161.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [161]
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Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-3-460_4 · Cited by 4,593
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041
Self-citationResolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Self-citationLeukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233
Self-citationNathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Robbins pathologic basis of disease
Cotran, R. S., Kumar, V., & Collins, T. (1989) · Medical Entomology and Zoology · Cited by 1,944
Psychogios, N., Hau, D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I. V., Krishnamurthy, R., Eisner, R., Gautam, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016957 · Cited by 1,779
The Nature and Significance of Platelet Products in Human Plasma
Wolf, P. (1967) · British Journal of Haematology · doi:10.1111/j.1365-2141.1967.tb08741.x · Cited by 1,725
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
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- Majno G Joris I. 2004. Cells Tissues and Disease: Principles of General Pathology 2nd ed. Oxford University Press New York NY.
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
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Efferocytosis in health and disease
Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066
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Cañedo‐Dorantes, L., & Cañedo-Ayala, M. (2019) · International Journal of Inflammation · doi:10.1155/2019/3706315 · Cited by 742
Technical challenges of working with extracellular vesicles
Ramirez, M. I., de Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., Nawaz, M., Akbar, N., Couch, Y., Makin, L., et al. (2017) · Nanoscale · doi:10.1039/c7nr08360b · Cited by 537
Macrophages: The Good, the Bad, and the Gluttony
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Metadata
- Authors
- Dalli, J., & Serhan, C.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2016-05-06
- Volume
- 4
- Issue
- 3
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC4922532
- OpenAlex
- W2473681996
- Cited by
- 121
- References
- 89
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 14 · 2017: 8
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology Spectrum (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P01GM095467, R01GM038765)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- specialized pro-resolving mediators, macrophages, neutrophils, efferocytosis, apoptotic neutrophils, M2 macrophages, M1 macrophages, resolvin D1, resolvin D2, maresin 1, leukotriene B4, lipoxin A4, lipidomics, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid
- MeSH terms
- Animals, Humans, Macrophages, Neutrophils, Inflammation Mediators, Lipid Metabolism, Cell-Derived Microparticles
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