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Cited by 90Genomics and Chromatin DynamicsNuclear Structure and FunctionEpigenetics and DNA Methylation

The epigenetic pathways to ribosomal DNA silencing

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Srivastava, Rakesh, Srivastava, Rashmi, Ahn, Seong Hoon·2016·Microbiology and Molecular Biology Reviews
DOI 10.1128/mmbr.00005-16PMC PMC4981667
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Abstract

SUMMARY: Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.

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Cited by

Sorted by citations

Authors
Srivastava, R., Srivastava, R., & Ahn, S. H.
Affiliations
Hanyang University (KR)
ORCID
Venue
Microbiology and Molecular Biology Reviews
Publisher
American Society for Microbiology
Published
2016-09
Volume
80
Issue
3
Pages
545-563
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
DOI
10.1128/mmbr.00005-16
PMC
PMC4981667
OpenAlex
W2416688624
Cited by
90
References
13
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 16 · 2020: 2 · 2019: 17 · 2018: 6 · 2017: 1 · 2016: 2
FWCI
0.78
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Microbiology and Molecular Biology Reviews (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
heterochromatin, epigenetic regulation, histone modifications, nucleolus, inner nuclear membrane, genome stability, cellular aging, Saccharomyces cerevisiae, chromosome segregation
MeSH terms
Acetylation, DNA, Ribosomal, Heterochromatin, Histones, Poly(ADP-ribose) Polymerases, Cellular Senescence, DNA Methylation, Gene Silencing, Ubiquitination

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