NuRD and SIN3

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429 · see citing works

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works

A transcriptional co-repressor that interacts with nuclear hormone receptors

Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794 · see citing works

Retinoblastoma protein recruits histone deacetylase to repress transcription

Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231 · see citing works

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., & Reinberg, D. (1999) · Genes & Development · doi:10.1101/gad.13.15.1924 · Cited by 1,103 · see citing works

Role of the histone deacetylase complex in acute promyelocytic leukaemia

Lin, R. J., Nagy, L., Inoue, S., Shao, W., Miller, W. H., & Evans, R. M. (1998) · Nature · doi:10.1038/35895 · Cited by 1,060 · see citing works

NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities

Xue, Y., Wong, J., Moreno, G. T., Young, M. K., Côté, J., & Wang, W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80299-3 · Cited by 983 · see citing works

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

Laherty, C. D., Yang, W., Sun, J.-M., Davie, J., Seto, E., & Eisenman, R. N. (1997) · Cell · doi:10.1016/s0092-8674(00)80215-9 · Cited by 933 · see citing works

Coactivator and corepressor complexes in nuclear receptor function

Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80021-5 · Cited by 897 · see citing works

Stabilization of Chromatin Structure by PRC1, a Polycomb Complex

Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J. R., Wu, C.-T., Bender, W. W., & Kingston, R. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80604-2 · Cited by 821 · see citing works

The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities

Zhang, Y., LeRoy, G., Seelig, H.-P., Lane, W. S., & Reinberg, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81758-4 · Cited by 814 · see citing works

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

Wade, P. A., Gégonne, A., Jones, P. L., Ballestar, E., Aubry, F., & Wolffe, A. P. (1999) · Nature Genetics · doi:10.1038/12664 · Cited by 811 · see citing works

Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development

Walhout, A. J. M., Sordella, R., Lu, X., Hartley, J. L., Temple, G. F., Brasch, M. A., Thierry‐Mieg, N., & Vidal, M. (2000) · Science · doi:10.1126/science.287.5450.116 · Cited by 757 · see citing works

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L., & Ayer, D. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80214-7 · Cited by 740 · see citing works

Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation

Yao, T., Segraves, W. A., Oro, A. E., McKeown, M., & Evans, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90266-f · Cited by 716 · see citing works

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E., & Schreiber, S. L. (1998) · Nature · doi:10.1038/27699 · Cited by 692 · see citing works

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

Kim, J., Sif, S., Jones, B., Jackson, A., Koipally, J., Heller, E., Winandy, S., Viel, A., Sawyer, A., Ikeda, T., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80034-5 · Cited by 587 · see citing works

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

Montgomery, M. K., Xu, S., & Fire, A. Z. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15502 · Cited by 580 · see citing works

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

Miska, E. A., Karlsson, C., Langley, E., Nielsen, S. J., Pines, J., & Kouzarides, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5099 · Cited by 551 · see citing works

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

van der Vlag, J., & Otte, A. P. (1999) · Nature Genetics · doi:10.1038/70602 · Cited by 527 · see citing works

PICKLE is a CHD3 chromatin-remodeling factor that regulates the transition from embryonic to vegetative development in Arabidopsis

Ogas, J., Kaufmann, S. H., Henderson, J. T., & Somerville, C. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13839 · Cited by 515 · see citing works

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila developmentPreprint

Chen, G., Fernandez, J., Mische, S. M., & Courey, A. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2218 · Cited by 444 · see citing works

A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase

Wade, P. A., Jones, P. L., Vermaak, D., & Wolffe, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70328-8 · Cited by 433 · see citing works

Untitled work

Ng (2000) · doi:10.1016/s0968-0004(00)01551-6 · Cited by 427 · see citing works

Conjunction dysfunction: CBP/p300 in human disease

Giles, R. H., Peters, D. J. M., & Breuning, M. H. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01438-3 · Cited by 400 · see citing works

Distinct Mechanisms Promote Polarity Establishment in Carpels of Arabidopsis

Eshed, Y., Baum, S. F., & Bowman, J. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81651-7 · Cited by 377 · see citing works

Sin Meets NuRD and Other Tails of Repression

Knoepfler, P. S., & Eisenman, R. N. (1999) · Cell · doi:10.1016/s0092-8674(00)81531-7 · Cited by 356 · see citing works

dMi-2, a Hunchback-Interacting Protein That Functions in Polycomb Repression

Kehle, J. (1998) · Science · doi:10.1126/science.282.5395.1897 · Cited by 354 · see citing works

Cellular Differentiation Regulated by Gibberellin in the Arabidopsis thaliana pickle Mutant

Ogas, J., Cheng, J.-C., Sung, Z. R., & Somerville, C. R. (1997) · Science · doi:10.1126/science.277.5322.91 · Cited by 344 · see citing works

The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional corepressor N-CoR and TFIIIB

Aasland, R., Stewart, A. F., & Gibson, T. J. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30009-1 · Cited by 334 · see citing works

lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48

Lu, X., & Horvitz, H. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81722-5 · Cited by 313 · see citing works

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

Koipally, J., Renold, A., Kim, J., & Georgopoulos, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3090 · Cited by 304 · see citing works

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th’ng, J., Han, J., & Yang, X.-J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7816 · Cited by 294 · see citing works

SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex

Zhang, Y., Sun, Z., Iratni, R., Erdjument‐Bromage, H., Tempst, P., Hampsey, M., & Reinberg, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80102-1 · Cited by 288 · see citing works

Drosophila Ecdysone Receptor Mutations Reveal Functional Differences among Receptor Isoforms

Bender, M., Imam, F. B., Talbot, W. S., Ganetzky, B., & Hogness, D. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80466-3 · Cited by 280 · see citing works

Histone deacetylases: transcriptional repression with SINers and NuRDs

Ayer, D. E. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01536-6 · Cited by 274 · see citing works

The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

Ferguson, E. L., & Horvitz, H. R. (1989) · Genetics · doi:10.1093/genetics/123.1.109 · Cited by 258 · see citing works

SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

Laherty, C. D., Billin, A., Lavinsky, R. M., Yochum, G., Bush, A. C., Sun, J.-M., Mullen, T., Davie, J. R., Rose, D., Glass, C. K., et al. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80111-2 · Cited by 231 · see citing works

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

Sewalt, R. G. A. B., van der Vlag, J., Gunster, M. J., Hamer, K. M., den Blaauwen, J. L., Satijn, D. P. E., Hendrix, T., DRIEL, R. V., & Otte, A. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3586 · Cited by 221 · see citing works

PcG complexes and chromatin silencing

Pirrotta, V. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80135-9 · Cited by 219 · see citing works

SMRTER, a Drosophila Nuclear Receptor Coregulator, Reveals that EcR-Mediated Repression Is Critical for Development

Tsai, C., Kao, H., Yao, T., McKeown, M., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80365-2 · Cited by 218 · see citing works

A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegansPreprint

Shi, Y., & Mello, C. C. (1998) · Genes & Development · doi:10.1101/gad.12.7.943 · Cited by 166 · see citing works

Control of lymphocyte development by the Ikaros gene family

Cortes, M., Wong, E., Koipally, J., & Georgopoulos, K. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80028-4 · Cited by 158 · see citing works

NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans

Solari, F., & Ahringer, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00343-2 · Cited by 153 · see citing works

Retinoblastoma protein meets chromatin

Brehm, A., & Kouzarides, T. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01368-7 · Cited by 148 · see citing works

Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans

Tan, P. B. O., & Kim, S. K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01694-7 · Cited by 132 · see citing works

Histone Acetylation Influences both Gene Expression and Development of Xenopus laevis

Almouzni, G., Khochbin, S., Dimitrov, S. I., & Wolffe, A. P. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1283 · Cited by 130 · see citing works

The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo

Mannervik, M., & Levine, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6797 · Cited by 113 · see citing works

The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning

Solari, F., Bateman, A. G., & Ahringer, J. (1999) · Development · doi:10.1242/dev.126.11.2483 · Cited by 112 · see citing works

A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

Neufeld, T. P., Tang, A., & Rubin, G. M. (1998) · Genetics · doi:10.1093/genetics/148.1.277 · Cited by 102 · see citing works

Analysis of the complete sequence of the novel metastasis-associated candidate gene, mtal, differentially expressed in mammary adenocarcinoma and breast cancer cell lines

Toh, Y., Pencil, S. D., & Nicolson, G. L. (1995) · Gene · doi:10.1016/0378-1119(94)00410-t · Cited by 101 · see citing works

Transcriptional silencing of homeotic genes in drosophila

Bienz, M., & Müller, J. (1995) · BioEssays · doi:10.1002/bies.950170907 · Cited by 100 · see citing works

The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB

Aasland, R. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)30009-1 · Cited by 95 · see citing works

EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans

Herman, M. A., Ch'ng, Q.-L., Hettenbach, S. M., Ratliff, T. M., Kenyon, C. J., & Herman, R. K. (1999) · Development · doi:10.1242/dev.126.5.1055 · Cited by 70 · see citing works

The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability

Pennetta, G., & Pauli, D. (1998) · Development Genes and Evolution · doi:10.1007/s004270050212 · Cited by 52 · see citing works

egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function

Ch'ng, Q.-L., & Kenyon, C. J. (1999) · Development · doi:10.1242/dev.126.15.3303 · Cited by 51 · see citing works

Transcriptional Repression by XPc1, a New Polycomb Homolog in Xenopus laevis Embryos, Is Independent of Histone Deacetylase

Strouboulis, J., Damjanovski, S., Vermaak, D., Meric, F., & Wolffe, A. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.3958 · Cited by 28 · see citing works

Untitled work

(1998) · doi:10.1002/(sici)1521-1878(199808)20:8

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works

Cooperation between Complexes that Regulate Chromatin Structure and Transcription

Narlikar, G. J., Fan, H.-Y., & Kingston, R. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00654-2 · Cited by 1,486 · see citing works

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

Yang, X., & Seto, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2346 · Cited by 1,239 · see citing works

HDAC family: What are the cancer relevant targets?

Witt, O., Deubzer, H. E., Milde, T., & Oehme, I. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.08.016 · Cited by 1,069 · see citing works

Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes

Pandey, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf660 · Cited by 783 · see citing works

Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex

Peinado, H., Ballestar, E., Esteller, M., & Cano, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.306-319.2004 · Cited by 766 · see citing works

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

Lagger, G., O'Carroll, D., Rembold, M., Khier, H., Tischler, J., Weitzer, G., Schuettengruber, B., Hauser, C., Brunmeir, R., Jenuwein, T., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2672 · Cited by 760 · see citing works

ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation

Nakamura, T., Mori, T., Tada, S., Krajewski, W. A., Rozovskaia, T., Wassell, R. P., DuBois, G. C., Mazo, A., Croce, C. M., & Canaani, E. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00740-2 · Cited by 720 · see citing works

Histone methylation versus histone acetylation: new insights into epigenetic regulation

Rice, J. C., & Allis, C. D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00208-8 · Cited by 701 · see citing works

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

Miączyńska, M., Christoforidis, S., Giner, A., Shevchenko, A., Uttenweiler‐Joseph, S., Habermann, B. H., Wilm, M. S., Parton, R. G., & Zerial, M. (2004) · Cell · doi:10.1016/s0092-8674(04)00117-5 · Cited by 536 · see citing works

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse developmentPreprint

Hendrich, B., Guy, J., Ramsahoye, B. H., Wilson, V. A., & Bird, A. P. (2001) · Genes & Development · doi:10.1101/gad.194101 · Cited by 526 · see citing works

Hormone interactions during lateral root formation

Fukaki, H., & Tasaka, M. (2008) · Plant Molecular Biology · doi:10.1007/s11103-008-9417-2 · Cited by 480 · see citing works

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

Liang, J., Wan, M., Zhang, Y., Gu, P., Xin, H., Jung, S. Y., Qin, J., Wong, J., Cooney, A. J., Liu, D., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1736 · Cited by 450 · see citing works

Regulated nucleosome mobility and the histone code

Cosgrove, M. S., Boeke, J. D., & Wolberger, C. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb851 · Cited by 421 · see citing works

The methyl-CpG binding domain and the evolving role of DNA methylation in animals

Hendrich, B., & Tweedie, S. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00080-5 · Cited by 397 · see citing works

Recruitment of O-GlcNAc Transferase to Promoters by Corepressor mSin3A

Yang, X., Zhang, F., & Kudlow, J. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00810-3 · Cited by 382 · see citing works

Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers

de la Serna, I. L., Ohkawa, Y., & Imbalzano, A. N. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1882 · Cited by 376 · see citing works

Functional significance of histone deacetylase diversity

Khochbin, S., Verdel, A., Lemercier, C., & Seigneurin-Berny, D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00174-x · Cited by 366 · see citing works

Recruitment of chromatin‐modifying enzymes by CTIP2 promotes HIV‐1 transcriptional silencing

Marban, C., Suzanne, S., Dequiedt, F., de Walque, S., Redel, L., Lint, C. M. V., Aunis, D., & Rohr, O. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601516 · Cited by 354 · see citing works

Methyl CpG-binding proteins and transcriptional repression

Wade, P. A. (2001) · BioEssays · doi:10.1002/bies.10008 · Cited by 351 · see citing works

Quantitation of HDAC1 mRNA Expression in Invasive Carcinoma of the Breast*

Zhang, Z., Yamashita, H., Toyama, T., Sugiura, H., Ando, Y., Mita, K., Hamaguchi, M., Hara, Y., Kobayashi, S., & Iwase, H. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-6001-1 · Cited by 307 · see citing works

Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance

Zhu, J., Jeong, J. C., Zhu, Y., Sokolchik, I., Miyazaki, S., Zhu, J., Hasegawa, P. M., Bohnert, H. J., Shi, H., Yun, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801029105 · Cited by 307 · see citing works

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

Cyr, A. R., & Domann, F. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3492 · Cited by 294 · see citing works

Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression

Schrem, H., Klempnauer, J., & Borlak, J. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.129 · Cited by 283 · see citing works

APPL1: role in adiponectin signaling and beyond

Deepa, S. S., & Dong, L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90731.2008 · Cited by 287 · see citing works

GATA‐1 forms distinct activating and repressive complexes in erythroid cells

Rodriguez, P., Bonte, E. J., Krijgsveld, J., Kolodziej, K. E., Guyot, B., Heck, A. J. R., Vyas, P., de Boer, E., Grosveld, F. G., & Strouboulis, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600702 · Cited by 267 · see citing works

Arabidopsis Histone Deacetylase HDA6 Is Required for Maintenance of Transcriptional Gene Silencing and Determines Nuclear Organization of rDNA Repeats

Probst, A. V., Fagard, M., Proux, F., Mourrain, P., Boutet‐Mercey, S., Earley, K. W., Lawrence, R. J., Pikaard, C. S., Murfett, J., Furner, I. J., et al. (2004) · The Plant Cell · doi:10.1105/tpc.018754 · Cited by 262 · see citing works

Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1

Zupkovitz, G., Tischler, J., Posch, M., Sadzak, I., Ramsauer, K., Egger, G., Grausenburger, R., Schweifer, N., Chiocca, S., Decker, T., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01220-06 · Cited by 262 · see citing works

Do protein motifs read the histone code?

de la Cruz, X., Lois, S., Sánchez-Molina, S., & Martínez‐Balbás, M. A. (2005) · BioEssays · doi:10.1002/bies.20176 · Cited by 258 · see citing works

Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes

Fuente, R. D. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.01.008 · Cited by 252 · see citing works

Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

Senese, S., Zaragoza, K., Minardi, S. P., Muradore, I., Ronzoni, S., Passafaro, A., Bernard, L., Draetta, G. F., Alcalay, M., Seiser, C., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00494-07 · Cited by 253 · see citing works

Epigenetics: interaction of DNA methylation and chromatin

Nakao, M. (2001) · Gene · doi:10.1016/s0378-1119(01)00721-1 · Cited by 251 · see citing works

Histone H3 Lysine 4 Methylation Disrupts Binding of Nucleosome Remodeling and Deacetylase (NuRD) Repressor Complex

Zegerman, P., Cañas, B., Pappin, D., & Kouzarides, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200045200 · Cited by 248 · see citing works

Structure and function insights into the NuRD chromatin remodeling complex

Torchy, M., Hamiche, A., & Klaholz, B. P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1880-8 · Cited by 244 · see citing works

Role of HDACs in normal and malignant hematopoiesis

Wang, P., Wang, Z., & Liu, J. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1127-7 · Cited by 237 · see citing works

The Constantly Changing Face of Chromatin

Vaquero, A., Loyola, A., & Reinberg, D. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.14.re4 · Cited by 237 · see citing works

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment

Reynolds, N., Latos, P., Hynes-Allen, A., Loos, R., Leaford, D., O'Shaughnessy, A., Mosaku, O., Signolet, J., Brennecke, P., Kalkan, T., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.020 · Cited by 236 · see citing works

The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase i transcription

Zhou, Y., Santoro, R., & Grummt, I. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf460 · Cited by 234 · see citing works

Surf the Post-translational Modification Network of p53 Regulation

Gu, B., & Zhu, W. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4283 · Cited by 234 · see citing works

Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo

Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., & Verdin, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104935200 · Cited by 232 · see citing works

Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteinswith ICP8

Taylor, T. J., & Knipe, D. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5856-5866.2004 · Cited by 229 · see citing works

Proteomics Analysis of Ring1B/Rnf2 Interactors Identifies a Novel Complex with the Fbxl10/Jhdm1B Histone Demethylase and the Bcl6 Interacting Corepressor

Sánchez, C., Sánchez, I., Demmers, J., Rodriguez, P., Strouboulis, J., & Vidal, M. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600275-mcp200 · Cited by 223 · see citing works

Reactivation of latent HIV by histone deacetylase inhibitors

Shirakawa, K., Chávez, L., Hakre, S., Calvanese, V., & Verdin, E. M. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.02.005 · Cited by 214 · see citing works

The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity

John, L. B., & Ward, A. C. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.03.006 · Cited by 231 · see citing works

Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways

Yamaguchi, M., Tonou‐Fujimori, N., Komori, A., Maeda, R., Nojima, Y., Li, H., Okamoto, H., & Masai, I. (2005) · Development · doi:10.1242/dev.01881 · Cited by 207 · see citing works

Identification of Arabidopsis Histone Deacetylase HDA6 Mutants That Affect Transgene Expression

Murfett, J., Wang, X., Hagen, G., & Guilfoyle, T. J. (2001) · The Plant Cell · doi:10.1105/tpc.13.5.1047 · Cited by 204 · see citing works

Epigenetic Modifications and Plant Hormone Action

Yamamuro, C., Zhu, J., & Yang, Z. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.10.008 · Cited by 197 · see citing works

Coordinate repression of regulators of embryonic identity by PICKLE during germination in Arabidopsis

Rider, S. D., Henderson, J. T., Jerome, R. E., Edenberg, H. J., Romero‐Severson, J., & Ogas, J. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01783.x · Cited by 194 · see citing works

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

Xia, Z., Anderson, M., Dı́az, M. O., & Zeleznik‐Le, N. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1436338100 · Cited by 194 · see citing works

Cancer Drug Discovery and Development

Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195 · see citing works

The nucleosome remodeling and deacetylase complex in development and disease

Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191 · see citing works

PICKLE is required for SOLITARY‐ROOT/IAA14‐mediated repression of ARF7 and ARF19 activity during Arabidopsis lateral root initiation

Fukaki, H., Taniguchi, N., & Tasaka, M. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02882.x · Cited by 191 · see citing works

Dermatomyositis and polymyositis

Mammen, A. L. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05119.x · Cited by 187 · see citing works

Identification and Characterization of Three New Components of the mSin3A Corepressor Complex

Fleischer, T. C., Yun, U. J., & Ayer, D. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3456-3467.2003 · Cited by 184 · see citing works

Chromatin remodelers: We are the drivers!!

Tyagi, M. V., Imam, N., Verma, K., & Patel, A. K. (2016) · Nucleus · doi:10.1080/19491034.2016.1211217 · Cited by 182 · see citing works

The emerging role of class II histone deacetylases

Fischle, W., Kiermer, V., Dequiedt, F., & Verdin, E. M. (2001) · Biochemistry and Cell Biology · doi:10.1139/bcb-79-3-337 · Cited by 182 · see citing works

Histone Deacetylase and DNA Methyltransferase in Human Prostate Cancer

Patra, S. K., Patra, A., & Dahiya, R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5639 · Cited by 176 · see citing works

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells

Kaji, K., Nichols, J., & Hendrich, B. (2007) · Development · doi:10.1242/dev.02802 · Cited by 176 · see citing works

Silencing of gene expression: implications for design of retrovirus vectors

Pannell, D., & Ellis, J. (2001) · Reviews in Medical Virology · doi:10.1002/rmv.316 · Cited by 174 · see citing works

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner

dos Santos, R. L., Tosti, L., Radzisheuskaya, A., Caballero, I. M., Kaji, K., Hendrich, B., & Silva, J. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.019 · Cited by 172 · see citing works

CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system

Thompson, P. M., Gotoh, T., Kok, M., White, P. S., & Brodeur, G. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206211 · Cited by 171 · see citing works

Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses Transcription

Meehan, W. J., Samant, R. S., Hopper, J. E., Carrozza, M. J., Shevde, L. A., Workman, J. L., Eckert, K. A., Verderame, M. F., & Welch, D. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307969200 · Cited by 168 · see citing works

Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex

Lu, J., Jeong, H., Kong, N., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., YupoMa, & Chai, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005577 · Cited by 168 · see citing works

The CHD3 Remodeler PICKLE Associates with Genes Enriched for Trimethylation of Histone H3 Lysine 27

Zhang, H., Bishop, B., Ringenberg, W., Muir, W. M., & Ogas, J. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.194878 · Cited by 157 · see citing works

The CHD3 Remodeler PICKLE Promotes Trimethylation of Histone H3 Lysine 27

Zhang, H., Rider, S. D., Henderson, J. T., Fountain, M., Chuang, K., Kandachar, V., Simons, A., Edenberg, H. J., Romero‐Severson, J., Muir, W. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802129200 · Cited by 150 · see citing works

Histone Deacetylases and ASYMMETRIC LEAVES2 Are Involved in the Establishment of Polarity in Leaves ofArabidopsis

Ueno, Y., Ishikawa, T., Watanabe, K., Terakura, S., Iwakawa, H., Okada, K., Machida, C., & Machida, Y. (2007) · The Plant Cell · doi:10.1105/tpc.106.042325 · Cited by 145 · see citing works

SATB2 interacts with chromatin‐remodeling molecules in differentiating cortical neurons

Gyorgy, A. B., Szemes, M., Romero, C. D. J., Tarabykin, V. S., & Ágoston, D. V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06061.x · Cited by 142 · see citing works

Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5

Gao, H., Lukin, K., Ramírez, J. A., Fields, S., Lopez, D., & Hagman, J. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809485106 · Cited by 141 · see citing works

A Conserved 12-Amino Acid Motif in Sall1 Recruits the Nucleosome Remodeling and Deacetylase Corepressor Complex

Lauberth, S. M., & Rauchman, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513461200 · Cited by 140 · see citing works

The human reelin gene: Transcription factors (+), repressors (−) and the methylation switch (+/−) in schizophrenia

Grayson, D. R., Chen, Y., Costa, E., Dong, E., Guidotti, A., Kundaković, M., & Sharma, R. P. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.007 · Cited by 139 · see citing works

Heterochromatin?many flavours, common themes

Craig, J. M. (2004) · BioEssays · doi:10.1002/bies.20145 · Cited by 138 · see citing works

Transcriptional repression in eukaryotes: repressors and repression mechanisms

Gaston, K., & Jayaraman, P.-S. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2260-3 · Cited by 137 · see citing works

Active repression by unliganded retinoid receptors in development

Weston, A. D., Blumberg, B., & Underhill, T. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211117 · Cited by 137 · see citing works

The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination

von Zelewsky, T., Palladino, F., Brunschwig, K., Tobler, H., Hajnal, A., & Müller, F. (2000) · Development · doi:10.1242/dev.127.24.5277 · Cited by 137 · see citing works

Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation

MacDonald, J. L., & Roskams, A. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.002 · Cited by 136 · see citing works

Transcriptional repressors: multifaceted regulators of gene expression

Reynolds, N., O’Shaughnessy, A., & Hendrich, B. (2013) · Development · doi:10.1242/dev.083105 · Cited by 132 · see citing works

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

Aguilera, C., Nakagawa, K., Sancho, R., Chakraborty, A., Hendrich, B., & Behrens, A. (2010) · Nature · doi:10.1038/nature09607 · Cited by 134 · see citing works

Metastasis Tumor Antigens, an Emerging Family of Multifaceted Master Coregulators

Manavathi, B., & Kumar, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600029200 · Cited by 134 · see citing works

Recruitment of Distinct Chromatin-modifying Complexes by Tamoxifen-complexed Estrogen Receptor at Natural Target Gene Promoters in Vivo*

Liu, X.-F., & Bagchi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311932200 · Cited by 147 · see citing works

Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5

Rascle, A., Johnston, J. A., & Amati, B. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4162-4173.2003 · Cited by 131 · see citing works

The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis

Daser, A., & Rabbitts, T. H. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.01.007 · Cited by 129 · see citing works

A Critical Evaluation of DNA Adducts as Biological Markers for Human Exposure to Polycyclic Aromatic Compounds

Godschalk, R., van Schooten, F., & Bartsch, H. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.001 · Cited by 125 · see citing works

The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast

Williams, R. M., Primig, M., Washburn, B. K., Winzeler, E. A., Bellis, M., de Menthière, C. S., Davis, R. W., & Esposito, R. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202495299 · Cited by 122 · see citing works

Histone Deacetylase in Carcinogenesis and Its Inhibitors as Anti-cancer Agents

Kim, D. H., Kim, M., & Kwon, H.-J. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.110 · Cited by 121 · see citing works

Transgenic Overexpression of Hdac3 in the Heart Produces Increased Postnatal Cardiac Myocyte Proliferation but Does Not Induce Hypertrophy

Trivedi, C. M., Lu, M. M., Wang, Q., & Epstein, J. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803686200 · Cited by 119 · see citing works

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

Ashe, A., Morgan, D. K., Whitelaw, N. C., Bruxner, T. J., Vickaryous, N. K., Cox, L. L., Butterfield, N. C., Wicking, C., Blewitt, M. E., Wilkins, S. J., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-12-r182 · Cited by 117 · see citing works

The conserved role of sirtuins in chromatin regulation

Vaquero, A. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082675av · Cited by 116 · see citing works

Transcriptional Regulation by the Repressor of Estrogen Receptor Activity via Recruitment of Histone Deacetylases

Kurtev, V., Margueron, R., Kroboth, K., Ogris, E., Cavaillès, V., & Seiser, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312300200 · Cited by 112 · see citing works

Tumor Suppressor SMAR1 Mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 Complex

Rampalli, S., Chavali, P. L., Bhatt, A., Kundu, T. K., & Chattopadhyay, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8415-8429.2005 · Cited by 119 · see citing works

The turnip Mutant of Arabidopsis Reveals That LEAFY COTYLEDON1 Expression Mediates the Effects of Auxin and Sugars to Promote Embryonic Cell Identity

Casson, S. A., & Lindsey, K. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.080895 · Cited by 111 · see citing works

Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 111Edited by J. Karn

Taplick, J., Kurtev, V., Kroboth, K., Posch, M., Lechner, T., & Seiser, C. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4569 · Cited by 108 · see citing works

CHD chromatin remodelers and the transcription cycle

Murawska, M., & Brehm, A. (2011) · Transcription · doi:10.4161/trns.2.6.17840 · Cited by 108 · see citing works

ATP‐dependent nucleosome remodeling complexes: Enzymes tailored to deal with chromatin

Sif, S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20005 · Cited by 107 · see citing works

Chromatin-Remodeling and Memory Factors. New Regulators of Plant Development

Reyes, J. C., Hennig, L., & Gruissem, W. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.006791 · Cited by 106 · see citing works

The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea

Scimone, M. L., Meisel, J. D., & Reddien, P. W. (2010) · Development · doi:10.1242/dev.042051 · Cited by 103 · see citing works

Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex

Lejon, S., Thong, S. Y., Murthy, A., AlQarni, S., Murzina, N. V., Blobel, G. A., Laue, E. D., & Mackay, J. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.195842 · Cited by 102 · see citing works

Solution Structure of the Interacting Domains of the Mad–Sin3 Complex

Brubaker, K., Cowley, S. M., Huang, K., Loo, L. W. M., Yochum, G. S., Ayer, D. E., Eisenman, R. N., & Radhakrishnan, I. (2000) · Cell · doi:10.1016/s0092-8674(00)00168-9 · Cited by 100 · see citing works

Transcriptional Regulation: a Genomic Overview

Riechmann, J. L. (2002) · The Arabidopsis Book · doi:10.1199/tab.0085 · Cited by 98 · see citing works

PICKLE acts during germination to repress expression of embryonic traits

Li, H., Chuang, K., Henderson, J. T., Rider, S. D., Bai, Y., Zhang, H., Fountain, M., Gerber, J., & Ogas, J. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02602.x · Cited by 98 · see citing works

MTA family of coregulators in nuclear receptor biology and pathology

Manavathi, B., Singh, K., & Kumar, R. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05010 · Cited by 97 · see citing works

Eloquent silence: developmental functions of Class I histone deacetylases

Cunliffe, V. T. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.10.001 · Cited by 95 · see citing works

Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex

Adams, G. E., Chandru, A., & Cowley, S. M. (2018) · Biochemical Journal · doi:10.1042/bcj20170314 · Cited by 123 · see citing works

Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repressionPreprint

Li, J., Lin, Q., Wang, W., Wade, P. A., & Wong, J. (2002) · Genes & Development · doi:10.1101/gad.962502 · Cited by 126 · see citing works

Histone deacetylases: transcriptional repression with SINers and NuRDs

Ayer, D. E. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01536-6 · Cited by 274 · see citing works

Systematic Analysis of SIN3 Histone Modifying Complex Components During Development

Barnes, V. L., Laity, K. A., Pilecki, M., & Pile, L. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-35093-0 · Cited by 16 · see citing works