Microbial NAD Metabolism: Lessons from Comparative Genomics

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Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

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Environmental genome shotgun sequencing of the sargasso sea

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology

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Genes required for mycobacterial growth defined by high density mutagenesis

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The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes

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Toward Automatic Reconstruction of a Highly Resolved Tree of Life

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?

de Buhr, N., & von Köckritz‐Blickwede, M. (2021) · mBio · doi:10.1128/mbio.03304-20 · Cited by 22

Sirtuin Evolution at the Dawn of Animal Life

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Identification of a Toxin–Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa

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Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis

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An NAD + -Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM

Olesen, S. V., Rajabi, N., Svensson, B., Olsen, C. A., & Madsen, A. S. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00306 · Cited by 16

Effects of Azole Fungicides on Secreted Metabolomes of Botrytis cinerea

Han, S.-H., Song, M., & Keum, Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00696 · Cited by 17

Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism

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Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia

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The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

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Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841

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NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota

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Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease

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Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases

Cialabrini, L., Ruggieri, S., Kazanov, M. D., Sorci, L., Mazzola, F., Orsomando, G., Osterman, A. L., & Raffaelli, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065595 · Cited by 15

De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever

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Functional definition of NrtR, a remnant regulator of NAD + homeostasis in the zoonotic pathogen Streptococcus suis

Wang, Q., Hassan, B. H., Lou, N., Merritt, J. L., & Feng, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201802179rr · Cited by 15

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

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Essential role of B ordetella NadC in a quinolinate salvage pathway for NAD biosynthesis

Brickman, T. J., Suhadolc, R. J., McKelvey, P. J., & Armstrong, S. K. (2016) · Molecular Microbiology · doi:10.1111/mmi.13566 · Cited by 14

A Key Enzyme of the NAD + Salvage Pathway in Thermus thermophilus: Characterization of Nicotinamidase and the Impact of Its Gene Deletion at High Temperatures

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Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria

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Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism

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Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition

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Colonic mechanism of serum NAD+ depletion induced by DEHP during pregnancy

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The Transcriptional Regulator BpsR Controls the Growth of Bordetella bronchiseptica by Repressing Genes Involved in Nicotinic Acid Degradation

Guragain, M., Jennings‐Gee, J. E., Cattelan, N., Finger, M. E., Conover, M. S., Hollis, T., & Deora, R. (2018) · Journal of Bacteriology · doi:10.1128/jb.00712-17 · Cited by 12

Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

Ito, T., Totoki, T., Takada, S., Otsuka, S., & Maruyama, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-99052-y · Cited by 12

NdnR is an NAD-responsive transcriptional repressor of the ndnR operon involved in NAD de novo biosynthesis in Corynebacterium glutamicum

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Crystal Structures of the Iron–Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate

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An Updated Review on the Mechanisms, Pre‐Clinical and Clinical Comparisons of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR)

Xu, Y., Lu, A., Guan, X., Ying, T., Pan, J., Tan, M., & Lu, J. (2024) · Food Frontiers · doi:10.1002/fft2.511 · Cited by 11

Mechanistic Characterization of Escherichia coli l -Aspartate Oxidase from Kinetic Isotope Effects

Chow, C., Hegde, S. S., & Blanchard, J. S. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00307 · Cited by 10

Lactate dehydrogenase is the Achilles’ heel of Lyme disease bacterium Borreliella burgdorferi

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Nicotinamidase from the thermophilic archaeon Acidilobus saccharovorans: Structural and functional characteristics

Stekhanova, T. N., Bezsudnova, E. Y., Mardanov, A. V., Osipov, E. M., Ravin, N. V., Георгиевич, С. К., & Popov, V. O. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914010088 · Cited by 10

Structural and molecular dynamics of ammonia transport in Staphylococcus aureus NH3-dependent NAD synthetase

Sultana, K. N., & Srivastava, S. K. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.138 · Cited by 10

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

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The NAD+ metabolism of Leishmania, notably the enzyme nicotinamidase involved in NAD+ salvage, offers prospects for development of anti‐parasite chemotherapy

Michels, P. A. M., & Avilán, L. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07810.x · Cited by 10

Hyperthermophilic Archaeon Thermococcus kodakarensis Utilizes a Four-Step Pathway for NAD + Salvage through Nicotinamide Deamination

Hachisuka, S.-I., Sato, T., & Atomi, H. (2018) · Journal of Bacteriology · doi:10.1128/jb.00785-17 · Cited by 10

Developing a single strain for in vitro salvage synthesis of NAD+ at high temperatures and its potential for bioconversion

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Genomic Insights and Plant Growth-Promoting Characterization of Priestia megaterium Strain 53B2, Isolated from Maize-Associated Soil in the Yaqui Valley, Mexico

Escalante-Beltrán, A., Sandoval, P. H. M., González-Astorga, C. B., Montoya-Martínez, A. C., Cubedo-Ruiz, E. A., Santoyo, G., Parra-Cota, F. I., & Santos‐Villalobos, S. D. L. (2025) · Plants · doi:10.3390/plants14132081 · Cited by 9

Computational Mechanistic Study of l -Aspartate Oxidase by ONIOM Method

Yıldız, İ. (2023) · ACS Omega · doi:10.1021/acsomega.3c01949 · Cited by 9

Structural insights into Xanthomonas campestris pv. campestris NAD+ biosynthesis via the NAM salvage pathway

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Kinetics and structural features of dimeric glutamine-dependent bacterial NAD+ synthetases suggest evolutionary adaptation to available metabolites

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Crystallographic and molecular dynamics simulation analysis of NAD synthetase from methicillin resistant Staphylococcus aureus (MRSA)

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Conformational Dynamics Contribute to Substrate Selectivity and Catalysis in Human Kynureninase

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Analysis of the gut microbiome to validate a mouse model of pellagra

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The Evolutionary Portrait of Metazoan NAD Salvage

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Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage

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Exploring NAD+ metabolism and NNAT: Insights from structure, function, and computational modeling

Jeje, O., Otun, S., Aloke, C., & Achilonu, I. (2024) · Biochimie · doi:10.1016/j.biochi.2024.01.002 · Cited by 9

An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase

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Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives

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An overview of engineering microbial production of nicotinamide mononucleotide

Li, B., Meng, X., & Liu, W. (2024) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2024.10.014 · Cited by 7

Biological production of nicotinamide mononucleotide: a review

Cabulong, R. B., Kafle, S. R., Singh, A., Sharma, M., & Kim, B. S. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2433993 · Cited by 7

Short-Term Probiotic Colonization Alters Molecular Dynamics of 3D Oral Biofilms

Udawatte, N. S., Liu, C., Staples, R., Han, P., Kumar, P., Arumugam, T. V., Ivanovski, S., & Seneviratne, C. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136403 · Cited by 7

Genome-wide transposon mutagenesis analysis of Burkholderia pseudomallei reveals essential genes for in vitro and in vivo survival

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Enhancing nicotinamide mononucleotide production from glucose in Escherichia coli by genetic engineering

Huang, W., Xu, J.-Z., & Zhang, W. (2023) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-023-00172-5 · Cited by 7

NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon

Afzal, M., Shafeeq, S., & Kuipers, O. P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01300 · Cited by 7

Enforcing energy consumption promotes microbial extracellular respiration for xenobiotic bioconversion

Liang, Z., Sun, H., Li, Y., Hu, A., Tang, Q., & Yu, H. (2023) · Environmental Microbiology · doi:10.1111/1462-2920.16484 · Cited by 7

An NAD+ biosynthetic pathway enzyme functions cell non‐autonomously in C. elegans development

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One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates

Szczepankiewicz, B. G., Koppetsch, K. J., & Perni, R. B. (2011) · The Journal of Organic Chemistry · doi:10.1021/jo2008466 · Cited by 7

Molecular Phenotyping and Genomic Characterization of a Novel Neuroactive Bacterium Strain, Lactobacillus murinus HU-1

Lebovitz, Y., & Theus, M. H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01162 · Cited by 7

Secondary-Electrospray Ionization Mass Spectrometry-Based Online Analyses of Mouse Volatilome Uncover Gut Microbiome-Dictated Metabolic Changes in the Host

Choueiry, F., Gold, A., Xu, R., Zhang, S., & Zhu, J. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.3c00304 · Cited by 6

Integration of Biological Networks for Acidithiobacillus thiooxidans Describes a Modular Gene Regulatory Organization of Bioleaching Pathways

Cortés, M. P., Acuña, V., Travisany, D., Siegel, A., Maass, A., & Latorre, M. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00155 · Cited by 6

Validation of NAD synthase inhibitors for inhibiting the cell viability ofLeishmania donovani:In silicoandin vitroapproach

Mandal, H., Vijayakumar, S., Yadav, S., Singh, S. K., & Das, P. K. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1552199 · Cited by 6

Pnc1p Supports Increases in Cellular NAD(H) Levels in Response to Internal or External Oxidative Stress

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Potential of exudate metabolites to predict microbial populations in beef

Hong, H., Kim, H.-J., Kim, H., Ismail, A., Choi, M., & Jo, C. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116814 · Cited by 5

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Chen, L., Yin, Z., Shang, L., Yuan, H., Gao, W., Wang, S., Wang, S., Hou, X., Yang, S., & Chu, H. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70447 · Cited by 5

Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target

Donu, D., Sharma, C., & Cen, Y. (2022) · Biomolecules · doi:10.3390/biom12081109 · Cited by 5

c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR

Mao, L., Li, J., Huo, X., Yang, W., Zhang, H., Duan, C., Shen, X., & Zhang, L. (2025) · mBio · doi:10.1128/mbio.01982-25 · Cited by 4

Competitive nitrogen/phosphorus scarcity triggers multi-pathway nitrogen removal and phosphorus-stress response in microalgae-bacterial symbiosis: poly-metabolic synergy enhancement mechanisms

Yang, L., Wei, W., Sun, X., Li, X., Wen, X., Mao, B., Hao, R., Qiu, W., & Li, H. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.134138 · Cited by 4

Interventions in Nicotinamide Adenine Dinucleotide Metabolism, the Intestinal Microbiota and Microcin Peptide Antimicrobials

Baquero, F., del Campo, R., & Martínez, J. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.861603 · Cited by 4

Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia

Matsumoto, S., Biniecka, P., Bellotti, A., Duchosal, M. A., & Nahimana, A. (2023) · Cancers · doi:10.3390/cancers15030787 · Cited by 4

Group B Vitamins: From Homeostasis to Pathogenesis and Treatment of Multiple Sclerosis

Abdurasulova, I. N., & Dmitriev, A. V. (2023) · Успехи физиологических наук · doi:10.31857/s0301179823010034 · Cited by 4

Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection

Janowicz, D. M., Zwickl, B., Fortney, K. R., Katz, B. P., & Bauer, M. E. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-166 · Cited by 4

Purification and characterization of the enzymes involved in nicotinamide adenine dinucleotide degradation by Penicillium brevicompactum NRC 829

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The function of KptA/Tpt1 gene – a minor review

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Biochemistry: Niacin/NAD(P)

Bogan, K. L., & Brenner, C. (2013) · Encyclopedia of Biological Chemistry · doi:10.1016/b978-0-12-378630-2.00103-1 · Cited by 4

METABOLIC PATHWAYS | Metabolism of Minerals and Vitamins

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Changes in Gut Microbiome Taxonomic Composition and Еheir Relationship to Biosynthetic and Metabolic Pathways of B Vitamins in Children with Multiple Sclerosis

Abdurasulova, I. N., Chernyavskaya, E. A., Ivanov, A. B., Nikitina, V., Lioudyno, V. I., Nartova, A. A., Matsulevich, A. V., Skripchenko, E. Y., Бисага, Г. Н., Игоревич, У. В., et al. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024010095 · Cited by 3

Valorizing agro-food waste for microbial B vitamin biosynthesis: impacts on gut microbiota dynamics and microbial communication

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Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis

Zhou, Z., Xu, Y., Huang, T., Zheng, J., Deng, Z., Dai, S., & Lin, S. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00773 · Cited by 3

Natural and Plant-Derived Vitamins: A Comprehensive Review of Biochemistry, Pharmacology and Nutritional Benefits in Health and Disease

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Systematic engineering for high-level production of β-nicotinamide mononucleotide from NAM and ribose

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NAD+ Boosting Strategies

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