Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 3,151 · see citing works

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0332-9 · Cited by 1,740 · see citing works

Sirtuins in mammals: insights into their biological function

Michán, S., & Sinclair, D. A. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,719 · see citing works

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works

Kynurenines in the mammalian brain: when physiology meets pathology

Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530 · see citing works

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060 · see citing works

NAD+ metabolism in health and disease

Belenky, P. A., Bogan, K. L., & Brenner, C. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.006 · Cited by 983 · see citing works

XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres

Waller, A. V. (1850) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1850.0021 · Cited by 889 · see citing works

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy

Zajączkowska, R., Kocot-Kępska, M., Leppert, W., Wrzosek, A., Mika, J., & Wordliczek, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061451 · Cited by 833 · see citing works

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750 · see citing works

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

Lewerenz, J., & Maher, P. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00469 · Cited by 721 · see citing works

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Osterloh, J. M., Yang, J. H., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M. A., et al. (2012) · Science · doi:10.1126/science.1223899 · Cited by 688 · see citing works

Axonal Self-Destruction and Neurodegeneration

Raff, M., Whitmore, A., & Finn, J. (2002) · Science · doi:10.1126/science.1068613 · Cited by 670 · see citing works

Intrinsic Control of Axon Regeneration

He, Z., & Jin, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.022 · Cited by 652 · see citing works

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646 · see citing works

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630 · see citing works

Wallerian degeneration: an emerging axon death pathway linking injury and disease

Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3680 · Cited by 611 · see citing works

Functional regeneration after laser axotomy

Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., & Ben-Yakar, A. (2004) · Nature · doi:10.1038/432822a · Cited by 598 · cited 2× · see citing works

Quinolinic acid, the inescapable neurotoxin

Guillemin, G. J. (2012) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08485.x · Cited by 595 · see citing works

SARM1 activation triggers axon degeneration locally via NAD ⁺ destruction

Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2015) · Science · doi:10.1126/science.1258366 · Cited by 593 · see citing works

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

Farina, M., Ávila, D. S., da Rocha, J. B. T., & Aschner, M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.006 · Cited by 558 · see citing works

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Parker, J. A., Arango-Lievano, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., & Néri, C. (2005) · Nature Genetics · doi:10.1038/ng1534 · Cited by 509 · see citing works

SIRT1 in Neurodevelopment and Brain Senescence

Herskovits, A. Z., & Guarente, L. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.028 · Cited by 493 · see citing works

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

Gilley, J., & Coleman, M. P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000300 · Cited by 472 · see citing works

Sirtuin activators and inhibitors: Promises, achievements, and challenges

Dai, H., Sinclair, D. A., Ellis, J. L., & Steegborn, C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.03.004 · Cited by 463 · see citing works

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

Bai, P. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.034 · Cited by 445 · see citing works

Biosynthesis of Diphosphopyridine Nucleotide

Preiss, J., & Handler, P. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64790-8 · Cited by 408 · see citing works

Biosynthesis of Diphosphopyridine Nucleotide

Preiss, J., & Handler, P. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64789-1 · Cited by 403 · see citing works

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α‐synuclein

Lakso, M., Vartiainen, S., Moilanen, A., Sirviö, J., Thomas, J. H., Nass, R., Blakely, R., & Wong, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01809.x · Cited by 398 · see citing works

Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway

Cui, L., Supinski, A., Savas, J. N., Yates, J. R., Bordone, L., Guarente, L., Cohen, D. E., Mazzulli, J. R., Krainc, D., & Jeong, H. (2011) · PubMed Central · doi:10.1038/nm.2559 · Cited by 367 · see citing works

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2558 · Cited by 344 · see citing works

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Luthi‐Carter, R., Taylor, D. M., Pallos, J., Lambert, E., Amore, A. M., Parker, J. A., Moffitt, H., Smith, D. L., Runne, H., Gökçe, Ö., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002924107 · Cited by 338 · see citing works

Peripheral Neuropathy Induced by Paclitaxel: Recent Insights and Future Perspectives

Scripture, C. D., Figg, W. D., & Sparreboom, A. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359568 · Cited by 320 · see citing works

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310 · see citing works

The kynurenine pathway and neurodegenerative disease

Maddison, D. C., & Giorgini, F. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.03.002 · Cited by 309 · see citing works

Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

Ghosh-Roy, A., Wu, Z.-L., Goncharov, A., Jin, Y.-S., & Chisholm, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5464-09.2010 · Cited by 304 · see citing works

Enzymology of NAD+ homeostasis in man

Magni, G., Amici, A., Emanuelli, M., Orsomando, G., Raffaelli, N., & Ruggieri, S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3161-1 · Cited by 289 · see citing works

Reconstructing eukaryotic NAD metabolism.

Rongvaux, A., Andris, F., Gool, F. V., & Leo, O. (2003) · Bioessays · doi:10.1002/bies.10297 · Cited by 284 · see citing works

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Pallos, J., Bodai, L., Lukácsovich, T., Purcell, J. M., Steffan, J. S., Thompson, L. M., & Marsh, J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn273 · Cited by 265 · see citing works

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cai, Q., & Jeong, Y. Y. (2020) · Cells · doi:10.3390/cells9010150 · Cited by 263 · see citing works

Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress

Garza-Lombó, C., Posadas, Y., Quintanar, L., Gonsebatt, M. E., & Franco, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7272 · Cited by 254 · see citing works

Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres

Waller, A. V. (1851) · Abstracts of the Papers Communicated to the Royal Society of London · doi:10.1098/rspl.1843.0224 · Cited by 246 · see citing works

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X. R., Yim, A. K., DiAntonio, A., & Milbrandt, J. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.024 · Cited by 234 · see citing works

NAD Biosynthesis

Kurnasov, O. V., Goral, V. N., Colabroy, K. L., Gerdes, S., Anantha, S., Osterman, A. L., & Begley, T. P. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.11.011 · Cited by 230 · see citing works

Microbial NAD Metabolism: Lessons from Comparative Genomics

Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., & Brenner, C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00042-08 · Cited by 230 · see citing works

Modeling Parkinson’s Disease in C. elegans

Cooper, J. F., & Raamsdonk, J. M. V. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171258 · Cited by 224 · see citing works

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

Chopra, V., Quinti, L., Kim, J., Vollor, L., Narayanan, K. L., Edgerly, C. K., Cipicchio, P. M., Lauver, M. A., Choi, S. H., Silverman, R. B., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.11.001 · Cited by 214 · see citing works

A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy

Fukuda, Y., Li, Y., & Segal, R. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00481 · Cited by 206 · see citing works

Axon Regeneration Pathways Identified by Systematic Genetic Screening in C. elegans

Chen, L., Wang, Z., Ghosh‐Roy, A., Hubert, T., Yan, D., O'Rourke, S., Bowerman, B. A., Wu, Z., Jin, Y., & Chisholm, A. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.009 · Cited by 196 · see citing works

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

Benedetto, A., Au, C., Ávila, D. S., Milatović, D., & Aschner, M. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001084 · Cited by 196 · see citing works

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182 · see citing works

Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells

Hwang, E. S., & Song, S. B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2527-8 · Cited by 178 · see citing works

An exploratory double‐blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with H untington's disease

Süßmuth, S. D., Salman, H., Landwehrmeyer, G. B., Farmer, R. E., Frost, C. D., Tripepi, G., Andersen, C. A. F., Bacco, M. D., Lamanna, C., Diodato, E., et al. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12512 · Cited by 177 · see citing works

Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

Neugebauer, R. C., Uciechowska, U., Meier, R., Hruby, H., Valkov, V., Verdin, E. M., Sippl, W., & Jung, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm700972e · Cited by 166 · see citing works

Therapeutic Advances for Huntington’s Disease

Kumar, A., Kumar, V., Singh, K., Kumar, S., Kim, Y.-S., Lee, Y.-M., & Kim, J.-J. (2020) · Brain Sciences · doi:10.3390/brainsci10010043 · Cited by 166 · see citing works

Neuropathology of Degenerative Cell Death inCaenorhabditis elegans

Hall, D. H., Gong, G., Garcı́a-Añoveros, J., Gong, L., Chalfie, M., & Driscoll, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01033.1997 · Cited by 163 · see citing works

The 'dying back' process. A common denominator in many naturally occurring and toxic neuropathies.

Jb, C. (1979) · PubMed · Cited by 151 · see citing works

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Ho, D. J., Calingasan, N. Y., Wille, E. J., Dumont, M., & Beal, M. F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.006 · Cited by 147 · see citing works

Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene

Perry, V. H., Lunn, E. R., Brown, M. C., Cahusac, S., & Gordon, S. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00433.x · Cited by 137 · see citing works

Sirtuin activators

Alcaín, F. J., & Villalba, J. M. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902762893 · Cited by 137 · see citing works

SARM1-specific motifs in the TIR domain enable NAD + loss and regulate injury-induced SARM1 activation

Summers, D. W., Gibson, D. A., DiAntonio, A., & Milbrandt, J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601506113 · Cited by 135 · see citing works

A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.

Brandt, R., Gergou, A., Wacker, I., Fath, T., & Hutter, H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.011 · Cited by 126 · see citing works

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

Gilley, J., Adalbert, R., Yu, G., & Coleman, M. P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1534-13.2013 · Cited by 123 · see citing works

Progressive neurodegeneration in C. elegans model of tauopathy

Miyasaka, T., Ding, Z., Gengyo-Ando, K., Oue, M., Yamaguchi, H., Mitani, S., & Ihara, Y. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.017 · Cited by 115 · see citing works

Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

Dimitriadi, M., & Hart, A. C. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.012 · Cited by 95 · see citing works

Metal-induced neurodegeneration in C. elegans

Chen, P., Martinez-Finley, E. J., Bornhorst, J., Chakraborty, S., & Aschner, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00018 · Cited by 82 · see citing works

Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back Neurodegeneration

Yaron, A., & Schuldiner, O. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.025 · Cited by 76 · see citing works

Crystal Structures of E. coli Nicotinate Mononucleotide Adenylyltransferase and Its Complex with Deamido-NAD

Zhang, H., Zhou, T., Kurnasov, O. V., Cheek, S., Grishin, N. V., & Osterman, A. L. (2002) · Structure · doi:10.1016/s0969-2126(01)00693-1 · Cited by 74 · see citing works

Axon death signalling in Wallerian degeneration among species and in disease

Rosell, A. L., & Neukomm, L. J. (2019) · Open Biology · doi:10.1098/rsob.190118 · Cited by 74 · see citing works

Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide

Song, S. B., Park, J., Chung, G. J., Lee, I. H., & Hwang, E. S. (2019) · Metabolomics · doi:10.1007/s11306-019-1604-4 · Cited by 72 · see citing works

Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss

Calixto, A., Jara, J. S., & Court, F. A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003141 · Cited by 66 · see citing works

Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model

Hosie, K. A., King, A. E., Blizzard, C. A., Vickers, J. C., & Dickson, T. C. (2012) · ASN NEURO · doi:10.1042/an20110031 · Cited by 56 · see citing works

Neuronal Regeneration inC. elegansRequires Subcellular Calcium Release by Ryanodine Receptor Channels and Can Be Enhanced by Optogenetic Stimulation

Sun, L., Shay, J., McLoed, M., Roodhouse, K., Chung, S., Clark, C. M., Pirri, J. K., Alkema, M. J., & Gabel, C. V. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4238-13.2014 · Cited by 53 · see citing works

Nmnat exerts neuroprotective effects in dendrites and axons

Wen, Y., Parrish, J. Z., He, R., Zhai, R. G., & Kim, M. D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.002 · Cited by 50 · see citing works

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

Kim, K. W., Tang, N. H., Piggott, C. A., Andrusiak, M. G., Park, S., Zhu, M., Kurup, N. S., Cherra, S. J., Wu, Z., Chisholm, A. D., et al. (2018) · eLife · doi:10.7554/elife.39756 · Cited by 49 · see citing works

Neuronal responses to stress and injury in C. elegans

Kim, K. W., & Jin, Y.-S. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.005 · Cited by 44 · see citing works

NAD+Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity inCaenorhabditis Elegans

Caito, S. W., & Aschner, M. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw030 · Cited by 43 · see citing works

Inhibiting poly(ADP-ribosylation) improves axon regeneration

Byrne, A. B., McWhirter, R. D., Sekine, Y., Strittmatter, S. M., Miller, D. M., & Hammarlund, M. (2016) · eLife · doi:10.7554/elife.12734 · Cited by 43 · see citing works

PARP inhibitors

Anwar, M., Aslam, H. M., & Anwar, S. (2015) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-014-0024-8 · Cited by 43 · see citing works

Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration

Brochier, C., Jones, J. I., Willis, D. E., & Langley, B. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509754112 · Cited by 39 · see citing works

The apoptotic engulfment machinery regulates axonal degeneration in C. elegans neurons

Nichols, A. L. A., Meelkop, E., Linton, C., Giordano-Santini, R., Sullivan, R. K. P., Donato, A., Nolan, C., Hall, D. H., Xue, D., Neumann, B., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.050 · Cited by 38 · see citing works

Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration

Chen, L., Nye, D. M. R., Stone, M. C., Weiner, A. T., Gheres, K. W., Xiong, X., Collins, C. A., & Rolls, M. M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006503 · Cited by 34 · see citing works

The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans

Gagnon, S., Hengartner, M. O., & Desnoyers, S. (2002) · Biochemical Journal · doi:10.1042/bj20020669 · Cited by 29 · see citing works

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury

Wang, X., Sekine, Y., Byrne, A. B., Cafferty, W. B. J., Hammarlund, M., & Strittmatter, S. M. (2016) · eNeuro · doi:10.1523/eneuro.0270-16.2016 · Cited by 28 · see citing works

Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans

Wang, W., McReynolds, M. R., Goncalves, J. F., Shu, M., Dhondt, I., Braeckman, B. P., Lange, S. E., Kho, K., Detwiler, A. C., Pacella, M. J., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662916 · Cited by 26 · see citing works

Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response

Mao, X. R., Kaufman, D. M., & Crowder, C. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.5 · Cited by 23 · see citing works

Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid

McReynolds, M. R., Wang, W., Holleran, L. M., & Hanna‐Rose, W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.c117.795344 · Cited by 23 · see citing works

Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation

Gubert, P., Puntel, B., Lehmen, T. F., Fessel, J. P., Cheng, P., Bornhorst, J., Trindade, L. S., Ávila, D. S., Aschner, M., & Soares, F. A. A. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.04.008 · Cited by 21 · see citing works

Sir-2.1 mediated attenuation of α-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans

Maulik, M., Mitra, S., Hunter, S., Hunstiger, M., Oliver, S. R., Bult‐Ito, A., & Taylor, B. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-26905-4 · Cited by 18 · see citing works

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans

Sangaletti, R., D’Amico, M., Grant, J., Della‐Morte, D., & Bianchi, L. K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006965 · Cited by 15 · see citing works

Climbing STAIRs towards clinical trials with a novel PARP-1 inhibitor for the treatment of ischemic stroke

Ford, A. L., & Lee, J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.001 · Cited by 11 · see citing works

Poly(ADP-Ribose) Metabolism Analysis in the Nematode Caenorhabditis elegans

St-Laurent, J.-F., & Desnoyers, S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-270-0_25 · Cited by 6 · see citing works

Mechanisms of Axonal Degeneration and Regeneration

Li, J., & Collins, C. A. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190456757.013.33 · Cited by 1 · see citing works

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia

Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00997-x · Cited by 148 · see citing works

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

Wu, W., Gong, X.-X., Qin, Z.-H., & Wāng, Y. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01576-w · Cited by 127 · see citing works

Technology and functional insights into the nicotinamide mononucleotide for human health

Liu, Y., Gong, J., Marshall, G., Su, C., Shi, J., & Xu, Z. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12612-2 · Cited by 18 · see citing works

Dithianon exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans

Lee, Y., Choi, S., & Kim, K. W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114752 · Cited by 15 · see citing works

Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans

Ruszkiewicz, J. A., Endig, L., Güver, E., Bürkle, A., & Mangerich, A. (2023) · Cells · doi:10.3390/cells12232728 · Cited by 5 · see citing works

De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans

Zhu, S., Zhang, R., Yao, L., Lin, Z., Li, Y., Li, S., & Wu, L. (2025) · Communications Biology · doi:10.1038/s42003-025-07984-2 · Cited by 4 · see citing works

Chemical ecology of an apex predator life cyclePreprint

Mucci, N. C., Jones, K. A., Cao, M., Wyatt, M. R., Foye, S., Kauffman, S., Taufer, M., Chikaraishi, Y., Steffan, S. A., Campagna, S. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.13.430781 · Cited by 2 · see citing works

Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans

Gonzalez-Lerma, P., Lloyd, C., Park, S. J., & Dawson-Scully, K. D. (2026) · PLoS ONE · doi:10.1371/journal.pone.0342236 · Cited by 2 · see citing works

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

Kim, K. W., Tang, N. H., Piggott, C. A., Andrusiak, M. G., Park, S., Zhu, M., Kurup, N. S., Cherra, S. J., Wu, Z., Chisholm, A. D., et al. (2018) · eLife · doi:10.7554/elife.39756 · Cited by 49 · see citing works

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269 · see citing works

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246 · see citing works

Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity

Paiva, B. S., Neves, D., Tomé, D., Costa, F. J., Bruno, I. C., Trigo, D., Silva, R. M., & Almeida, R. D. (2025) · Cells · doi:10.3390/cells14080582 · Cited by 7 · see citing works

Nicotinamide adenine dinucleotide prevents axonal degeneration.

Qi, X., Li, Z., Zhang, J., Liu, W., Lü, J., Peng, F., Yang, J., & Sun, J. (2009) · Journal of Shandong University