The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Energetics of bacterial growth: balance of anabolic and catabolic reactions
Open accessAbstract
Biomass formation represents one of the most basic aspects of bacterial metabolism. While there is an abundance of information concerning individual reactions that result in cell duplication, there has been surprisingly little information on the bioenergetics of growth. For many years, it was assumed that biomass production (anabolism) was proportional to the amount of ATP which could be derived from energy-yielding pathways (catabolism), but later work showed that the ATP yield (YATP) was not necessarily a constant. Continuous-culture experiments indicated that bacteria utilized ATP for metabolic reactions that were not directly related to growth (maintenance functions). Mathematical derivations showed that maintenance energy appeared to be a growth rate-independent function of the cell mass and time. Later work, however, showed that maintenance energy alone could not account for all the variations in yield. Because only some of the discrepancy could be explained by the secretion of metabolites (overflow metabolism) or the diversion of catabolism to metabolic pathways which produced less ATP, it appeared that energy-excess cultures had mechanisms of spilling energy. Bacteria have the potential to spill excess ATP in futile enzyme cycles, but there has been little proof that such cycles are significant. Recent work indicated that bacteria can also use futile cycles of potassium, ammonia, and protons through the cell membrane to dissipate ATP either directly or indirectly. The utility of energy spilling in bacteria has been a curiosity. The deprivation of energy from potential competitors is at best a teleological explanation that cannot be easily supported by standard theories of natural selection. The priming of intracellular intermediates for future growth or protection of cells from potentially toxic end products (e.g., methylglyoxal) seems a more plausible explanation.
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“Others have noted an uncoupling between catabolism and anabolism, attributing the difference to factors such as varying maintenance costs or energy spilling via futile cycles (Russell et al., 1995), and the model’s prediction estimates the total energy cost of such uncoupling.”
From A Whole-Cell Computational Model Predicts Phenotype from Genotype (2012) · cites this paper as Russell et al., 1995
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Cites
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
MITCHELL, P. (1961) · Nature · doi:10.1038/191144a0 · Cited by 4,704
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Self-citationThe maintenance energy of bacteria in growing cultures
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Self-citationRegulation of cytoplasmic pH in bacteria
Booth, I. R. (1985) · Microbiological Reviews · doi:10.1128/mmbr.49.4.359-378.1985 · Cited by 1,200
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Cited by
Microbial Cellulose Utilization: Fundamentals and Biotechnology
Lynd, L. R., Weimer, P. J., van Zyl, W. H., & Pretorius, I. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.506-577.2002 · Cited by 4,726
A Whole-Cell Computational Model Predicts Phenotype from Genotype
Karr, J. R., Sanghvi, J. C., Macklin, D. N., Gutschow, M. V., Jacobs, J. M., Bolival, B., Assad-Garcia, N., Glass, J. I., & Covert, M. W. (2012) · Cell · doi:10.1016/j.cell.2012.05.044 · Cited by 1,300
Carbon use efficiency of microbial communities: stoichiometry, methodology and modelling
Sinsabaugh, R. L., Manzoni, S., Moorhead, D. L., & Richter, A. (2013) · Ecology Letters · doi:10.1111/ele.12113 · Cited by 991
Soil carbon and nitrogen mineralization: Theory and models across scales
Manzoni, S., & Porporato, A. (2009) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2009.02.031 · Cited by 788
Sauer, U., Canonaco, F., Heri, S., Perrenoud, A., & Fischer, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311657200 · Cited by 616
Metadata
- Authors
- Russell, J. B., & Cook, G. M.
- Affiliations
- Agricultural Research Service (US)
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1995-03
- Volume
- 59
- Issue
- 1
- Pages
- 48-62
- ISSN
- 0146-0749 (ISSN-L)
- PMC
- PMC239354
- OpenAlex
- W2112515372
- Cited by
- 927
- References
- 126
- Citations by year
- 2026: 46 · 2025: 40 · 2024: 38 · 2023: 48 · 2022: 39 · 2021: 57 · 2020: 63 · 2019: 51 · 2018: 37 · 2017: 35 · 2016: 42 · 2015: 30 · 2014: 40 · 2013: 30 · 2012: 36
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
- Locations
- Microbiological Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- anabolism, catabolism, ATP yield, maintenance energy, biomass yield, overflow metabolism, methylglyoxal, continuous culture
- MeSH terms
- Adenosine Triphosphate, Bacteria, Energy Metabolism, Substrate Cycling
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- Russell, J. B., & Cook, G. M. (1995). Energetics of bacterial growth: balance of anabolic and catabolic reactions. Microbiological Reviews. https://doi.org/10.1128/mr.59.1.48-62.1995
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
