Human Telomerase and Its Regulation

Cites (276)

Items 201–276 of 276

1. Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT
   Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., Inoue, M. · 2000 · Nucleic Acids Research
2. Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells
   Cuthbert, A. P., Bond, J., Trott, D. A., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, E. K., Cooper, C. S., Newbold, R. F. · 1999 · JNCI Journal of the National Cancer Institute
3. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters
   A S Majumdar, D E Hughes, Serge Lichtsteiner, Z Wang, JANE S. LEBKOWSKI, Alain P. Vasserot · 2001 · Gene Therapy
4. Cdc25B activity is regulated by 14-3-3
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5. Functional Multimerization of Human Telomerase Requires an RNA Interaction Domain in the N Terminus of the Catalytic Subunit
   Tara J. Moriarty, Sylvain Huard, Sophie Dupuis, Chantal Autexier · 2002 · Molecular and Cellular Biology
6. A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter
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7. Mapping of the Gene for the Human Telomerase Reverse Transcriptase, hTERT, to Chromosome 5p15.33 by Fluorescence in Situ Hybridization
   LA Bryce, Norma Morrisont, Stacey F. Hoare, Sharon Muir, W. Nicol Keith · 2000 · Neoplasia
8. Rb-mediated chromatin structure regulation and transcriptional repression
   H Steven Zhang, Douglas C. Dean · 2001 · Oncogene
9. Telomerase Activity Does Not Always Imply Telomere Maintenance
   Michel M. Ouellette, Dara L. Aisner, Isabelle Savre‐Train, Woodring Erik Wright, Jerry W. Shay · 1999 · Biochemical and Biophysical Research Communications
10. Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells
    Dawei Xu, Sven Erickson, Michael Szeps, Astrid Gruber, Olle Sangfelt, Stefan Einhorn, Pavel Pisa, Dan Grandér · 2000 · Blood
11. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents.
    Wei Zhang, Mieczyslaw A. Piatyszek, Tohru Kobayashi, Elihu H. Estey, Michael Andreeff, Albert Deisseroth, Woodring Erik Wright, Jerry W. Shay · 1996 · PubMed
12. hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro
    Stéphan Fiset · 2001 · Nucleic Acids Research
13. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity
    Kai Ge, James B. DuHadaway, Daitoku Sakamuro, Robert J. Wechsler‐Reya, Carol A. Reynolds, George C. Prendergast · 2000 · International Journal of Cancer
14. hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity
    Jian Hong Gu, Michael Andreeff, JA Roth, Bingliang Fang · 2002 · Gene Therapy
15. RNA location and modeling of a WD40 repeat domain within the vault
    Lawrence B. Kong, Amara C. Siva, Valerie A. Kickhoefer · 2000 · RNA
16. Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo
    Yie Liu, Bryan E. Snow, Manoor Prakash Hande, Gabriela Maria Baerlocher, Valerie A. Kickhoefer, David Yeung, Andrew C. Wakeham, Annick Itié, David Peter Siderovski, Peter M. Lansdorp et al. · 2000 · Molecular and Cellular Biology
17. The papillomavirus E6 proteins
    Lisa Rapp, Jason J. Chen · 1998 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
18. Multiple pathways to cellular senescence: Role of telomerase repressors
    Mitsuo Oshimura, J. Carl Barrett · 1997 · European Journal of Cancer
19. 5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.
    Junichi Hisatake, Tetsuya Kubota, Yasuko Hisatake, Milan R. Uskoković, Shigeru Tomoyasu, Harold Phillip Koeffler · 1999 · PubMed
20. Ciliate Telomerase Biochemistry
    Kathleen Collins · 1999 · Annual Review of Biochemistry
21. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A.
    Jonas Fuxe, Göran Akusjärvi, Helena M. Goike, Göran Roos, V. Peter Collins, R F Pettersson · 2000 · PubMed
22. Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana
    Keiko Oguchi, Hongtu Liu, Katsunori Tamura, Hideo Takahashi · 1999 · FEBS Letters
23. De novo telomere addition by Tetrahymena telomerase in vitro
    Hua Wang, Elizabeth Helen Blackburn · 1997 · The EMBO Journal
24. Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells.
    Hua Yang, Satoru Kyo, M Takatura, Lu‐Zhe Sun · 2001 · PubMed
25. Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding
    Tara L. Beattie, Wen Zhou, Murray O. Robinson, Lea A. Harrington · 2000 · Molecular Biology of the Cell
26. Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
    Dawei Xu, Astrid Gruber, Magnus Björkholm, C. Peterson, Pavel Pisa · 1999 · British Journal of Cancer
27. Heterogeneous Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component of Human Telomerase
    Lance P. Ford, Jae Myoung Suh, Woodring Erik Wright, Jerry W. Shay · 2000 · Molecular and Cellular Biology
28. Human Papillomavirus Type 16 E6-Induced Degradation of E6TP1 Correlates with Its Ability To Immortalize Human Mammary Epithelial Cells
    Qingshen Gao, Latika Singh, Ajay Kumar, Seetha V. Srinivasan, David E. Wazer, Vimla Band · 2001 · Journal of Virology
29. Expression of Telomerase Activity in Human Endometrium Is Localized to Epithelial Glandular Cells and Regulated in a Menstrual Phase-Dependent Manner Correlated with Cell Proliferation
    Masaaki Tanaka, Satoru Kyo, Masahiro Takakura, Taro Kanaya, Tetsuya Sagawa, Kaname Yamashita, Yasunori Okada, Eiso Hiyama, Masaki Inoue · 1998 · American Journal Of Pathology
30. Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p
    Christophe Dez · 2001 · Nucleic Acids Research
31. p53-Induced Apoptosis as a Safeguard against Cancer
    Charlotte Asker, Klas G. Wiman, Galina Selivanova · 1999 · Biochemical and Biophysical Research Communications
32. The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions
    Sun‐Hee Leem, Arturo Londoño‐Vallejo, Jung-Hyun Kim, Hung Bui, Emmanuel Tubacher, Gregory G. Solomon, Jung‐Eun Park, Izumi Horikawa, Natalay Kouprina, J. Carl Barrett et al. · 2002 · Oncogene
33. CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia
    Oliver Edgar Bechter, Wolfgang Eisterer, Margit Dlaska, Thomas Kühr, Josef Thaler · 2002 · Experimental Hematology
34. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells.
    M Kusumoto, Takahiro Ogawa, Kazuhiro Mizumoto, Hikaru Ueno, Hideaki Niiyama, Norihiro Sato, Masafumi Nakamura, Masao Tanaka · 1999 · PubMed
35. In Vivo and in Vitro Analyses of Myc for Differential Promoter Activities of the Human Telomerase (hTERT) Gene in Normal and Tumor Cells
    Sangtaek Oh, Young‐Hwa Song, Ung-Jin Kim, Jeongbin Yim, Tae Kook Kim · 1999 · Biochemical and Biophysical Research Communications
36. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer
    Maryse Delehedde, Song H. Cho, Mona G. Sarkiss, Shawn M. Brisbay, Michael A. Davies, Adel K. El‐Naggar, Timothy J. McDonnell · 1999 · Cancer
37. Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
    Hippokratis Kiaris, Andrew Victor Schally · 1999 · Proceedings of the National Academy of Sciences
38. Telomerase Suppression by Chromosome 6 in a Human Papillomavirus Type 16-Immortalized Keratinocyte Cell Line and in a Cervical Cancer Cell Line
    Renske D.M. Steenbergen, Duco Kramer, Chris J.L.M. Meijer, Jan M.M. Walboomers, D. A. Trott, Andrew P. Cuthbert, Robert F. Newbold, Wilhelmina J. I. Overkamp, Małgorzata Z. Zdzienicka, Peter J.F. Snijders · 2001 · JNCI Journal of the National Cancer Institute
39. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans
    Harmit Singh Malik, William D. Burke, Thomas H. Eickbush · 2000 · Gene
40. Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers
    TuDung T. Nguyen, Carvell T. Nguyen, Felicidad A. Gonzales, Peter W. Nichols, Mimi C. Yu, Peter A. Jones · 2000 · The Prostate
41. Inactivation of 14-3-3σ Influences Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability
    Sonu Dhar, Jeremy Andrew Squire, Manoor Prakash Hande, Raymund J. Wellinger, Tej Krishan Pandita · 2000 · Molecular and Cellular Biology
42. Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system
    Yasuo Nakayama, Hideki Sakamoto, Kazuo Satoh, Tatsuo Yamamoto · 2000 · Cancer Letters
43. Species-Specific Interaction of the Glutamine-Rich Activation Domains of Spl with the TATA Box-Binding Protein
    Andrew Emili, Jack Greenblatt, C. James Ingles · 1994 · Molecular and Cellular Biology
44. Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells
    Cheng-Chou Yu, Shi-Ching LO, Tzu‐Chien V. Wang · 2001 · Biochemical Journal
45. Reconstitution of Wild-Type or Mutant Telomerase Activity in Telomerase-Negative Immortal Human Cells
    J. Wen, Yunxia Cong, Silvia Bacchetti · 1998 · Human Molecular Genetics
46. Functional Reconstitution of Human Telomerase Expressed inSaccharomyces cerevisiae
    François Bachand, Chantal Autexier · 1999 · Journal of Biological Chemistry
47. The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo
    Lance P. Ford, Jerry W. Shay, Woodring Erik Wright · 2001 · RNA
48. Human telomerase RNA-protein interactions
    François Bachand · 2001 · Nucleic Acids Research
49. WT1—more than a transcription factor?
    Christoph Englert · 1998 · Trends in Biochemical Sciences
50. Functional evidence for a telomerase repressor gene on human chromosome 10p15.1
    Arata Nishimoto, Norimasa Miura, Izumi Horikawa, Hiroyuki Kugoh, Yoshinori Murakami, Setsuo Hirohashi, Hironaka Kawasaki, Adi F. Gazdar, Jerry W. Shay, J. Carl Barrett et al. · 2001 · Oncogene
51. Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus
    Ying C. Henderson, Randall L. Breau, Ta-Jen Liu, Gary L. Clayman · 2000 · Head & Neck
52. Rb and E2F-1 regulate telomerase activity in human cancer cells
    David L. Crowe, Dan C. Nguyen · 2001 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
53. A disease of premature ageing
    Inderjeet S Dokal · 2001 · The Lancet
54. Regulation of telomerase during human placental differentiation: a role for TGFβ1
    S. Rama, Y. Suresh, A. Jagannadha Rao · 2001 · Molecular and Cellular Endocrinology
55. Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells.
    Yoko Koyanagi, Daisuke Kobayashi, Tomomi Yajima · 2000 · PubMed
56. Microcell‐mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity
    Claudia Backsch, Nikola Wagenbach, Marion Nonn · 2001 · Genes Chromosomes and Cancer
57. ACCELERATED PAPER: Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A(p16INK4A)
    Nicole L. England, Andrew P. Cuthbert, Deborah A. Trott, Sarah Jezzard, Tsutomu Nobori, Dennis A. Carson, Robert F. Newbold · 1996 · Carcinogenesis
58. Identification of a Novel Transcription Factor Binding Element Involved in the Regulation by Differentiation of the Human Telomerase (hTERT) Promoter
    Maty Tzukerman, Catherine M. Shachaf, Yael Ravel, Ilana Braunstein, Orit Cohen‐Barak, Michal Yalon-Hacohen, Karl L. Skorecki · 2000 · Molecular Biology of the Cell
59. Testing telomerase
    Robert A. Marciniak, Leonard Guarente · 2001 · Nature
60. Induction of telomerase activity by UV-irradiation in Chinese hamster cells
    Manoor Prakash Hande, Adayabalam S. Balajee, A.T. Natarajan · 1997 · Oncogene
61. Toward Identifying a Cellular Determinant of Telomerase Repression
    Jerry W. Shay · 1999 · JNCI Journal of the National Cancer Institute
62. Cell-cycle-dependent turnover of P-glycoprotein in multidrug-resistant cells
    Wandong Zhang, Victor Wei Teik Ling · 2000 · Journal of Cellular Physiology
63. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue.
    V. Rohde, Hans‐Peter Sattler, Thorsten Bund, Helmut Bonkhoff, Thomas Fixemer, C Bachmann, Ramona Lensch, Gerhard Unteregger, Mark Y. Stoeckle, Bernd Wullich · 2000 · PubMed
64. Introduction of Chromosome 7 Suppresses Telomerase with Shortening of Telomeres in a Human Mesothelial Cell Line
    Kazuhiko Nakabayashi · 1999 · Experimental Cell Research
65. The Tetrahymena p80/p95 Complex Is Required for Proper Telomere Length Maintenance and Micronuclear Genome Stability
    Michael C. Miller, Kathleen Collins · 2000 · Molecular Cell
66. Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity
    Dan C. Nguyen, David L. Crowe · 1999 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
67. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus
    Yoshihito Yokoyama · 2001 · Molecular Human Reproduction
68. New Function of CDC13 in Positive Telomere Length Regulation
    Bettina Meier, Lucia Driller, Sigrun Jaklin, Heidi M. Feldmann · 2001 · Molecular and Cellular Biology
69. Differential Inhibition of Telomerase Activity during Induction of Differentiation in Hematopoietic, Melanoma, and Glioma Cells in Culture
    Ann‐Joy Cheng, Shuen-Kuel Liao, Shu‐Er Chow · 1997 · Biochemical and Biophysical Research Communications
70. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality
    Yuriko Ishii, Naohiro Tsuyama, Shizuko Maeda, Hidetoshi Tahara, Toshinori Ide · 1999 · Mechanisms of Ageing and Development
71. TRF1 Inhibits Telomere C-Strand DNA Synthesis in Vitro
    Elizabeth J. Donald, John J. Turchi · 2001 · Biochemistry
72. Two telomerase reverse transcriptases (TERTs) expressed in Candida albicans
    Anneke M. Metz, Ruschelle Ann Love, Gary Allan Strobel, David M. Long · 2001 · Biotechnology and Applied Biochemistry
73. Cloning and expression of hamster telomerase catalytic subunit cDNA
    W. Guo, Masanori Okamoto, N.-H. Park · 2001 · International Journal of Molecular Medicine
74. hTR repressor-related gene on human chromosome 10p15.1
    Natsuko Miura, Naoyoshi Onuki, Aditi Rathi, A K Virmani, Shu Nakamoto, Yui Kishimoto, Yoshikazu Murawaki, H Kawasaki, Junichi Hasegawa, Mitsuo Oshimura et al. · 2001 · British Journal of Cancer
75. Tetrahymena proteins p80 and p95 are not core telomerase components
    Douglas X. Mason, Chantal Autexier, Carol W. Greider · 2001 · Proceedings of the National Academy of Sciences
76. Telomerase activity in human germline and embryonic tissues and cells
    Wright, Woodring E., Piatyszek, Mieczyslaw A., Rainey, William E., Byrd, William, Shay, Jerry W. · 1996 · Developmental Genetics