Discovery of a Novel Antifungal Agent in the Pathogen Box
Open accessAbstract
Cryptococcus neoformans and Candida albicans are two major human fungal pathogens and together account for over 1.4 million infections annually, with very high mortality rates. These fungi often infect immunocompromised individuals, such as HIV/AIDS patients. In an effort to identify novel drugs with antifungal activity, we have screened the Pathogen Box for compounds with anticryptococcal and anticandidal activities. This approach led to the discovery of a promising lead compound (MMV688271) with strong antifungal potency under nutrient-limited conditions.
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The Malaria Box and the Pathogen Box have been screened for molecules with activity against fungal pathogens, including C. neoformans.
“For example, the Malaria Box and the Pathogen Box of Medicines for Malaria Venture, which are collections of diverse molecules that are active against malaria and neglected tropical diseases, have now been screened for molecules with activity against fungal pathogens, including C. neoformans88,89.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [89]
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- Authors
- Mayer, F. L., & Kronstad, J. W.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Kronstad, James W.
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2017-04-26
- Volume
- 2
- Issue
- 2
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC5390095
- OpenAlex
- W2606931784
- Cited by
- 49
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 3
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (MA6248/1-1)
- Gouvernement du Canada | Canadian Institutes of Health Research (MOP-13234)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- antifungal agents, Cryptococcus neoformans, Candida albicans, anticandidal activity, lead compound identification, immunocompromised patients, HIV/AIDS
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