Human and rat gut microbiome composition is maintained following sleep restriction
Open accessAbstract
Significance: It is widely presumed that there is a relationship between sleep and the gut microbiome because both sleep restriction and dysbiosis of the gut microbiome are associated with metabolic diseases such as obesity and diabetes. Here, we report sleep restriction over several consecutive days does not overtly influence the composition of the microbiome of either rats or humans, despite both species showing other changes associated with sleep loss. These analyses suggest that sleep loss and microbial dysbiosis have independent effects on the development of metabolic diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies reported a loss of association between sleep disturbances and CRP after adjustment for interfering factors, or did not detect a significant association.
“some studies reported a loss of association after adjustment for interfering factors (602), or did not detect a significant association between indices of sleep disturbances and CRP”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [602]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Self-citationSearch and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
APE: Analyses of Phylogenetics and Evolution in R language
Paradis, E., Claude, J., & Strimmer, K. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg412 · Cited by 12,037 · see citing works
16S ribosomal DNA amplification for phylogenetic study
Weisburg, W. G., Barns, S. M., Pelletier, D. A., & Lane, D. J. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.2.697-703.1991 · Cited by 11,957 · see citing works
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works
PyNAST: a flexible tool for aligning sequences to a template alignment
Caporaso, J. G., Bittinger, K. L., Bushman, F. D., DeSantis, T. Z., Andersen, G. L., & Knight, R. D. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp636 · Cited by 3,374 · see citing works
Self-citationGut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Self-citationDinges, D. F., Pack, F. M., Williams, K., Gillen, K. A., Powell, J. W., Ott, G. E., Trasande, C. A., & Pack, A. I. (1997) · SLEEP · doi:10.1093/sleep/20.4.267 · Cited by 2,018 · see citing works
Self-citationTranskingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
Molecular Identification of Bacteria Associated with Bacterial Vaginosis
Fredricks, D. N., Fiedler, T. L., & Marrazzo, J. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043802 · Cited by 1,303 · see citing works
Smith, C. S., Reilly, C., & Midkiff, K. (1989) · Journal of Applied Psychology · doi:10.1037/0021-9010.74.5.728 · Cited by 1,106 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.003 · Cited by 783 · see citing works
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671 · cited 2× · see citing works
“Proc Natl Acad Sci USA 101(44):15718–15723.”
BackgroundRhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works
Self-citationThe Sleep Disorders Questionnaire I: Creation and Multivariate Structure of SDQ
Douglass, A. B., Bomstein, R., Nino‐Murcia, G., Keenan, S. A., Miles, L. E. M., Zarcone, V. P., Guilleminault, C., & Dement, W. C. (1994) · SLEEP · doi:10.1093/sleep/17.2.160 · Cited by 560 · see citing works
He, X., McLean, J. S., Edlund, A., Yooseph, S., Hall, A. P., Liu, S.-Y., Dorrestein, P. C., Esquenazi, E., Hunter, R. C., Cheng, G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419038112 · Cited by 549 · see citing works
Effect of sleep deprivation on the human metabolome
Davies, S. K., Ang, J. E., Revell, V. L., Holmes, B., Mann, A., Robertson, F. P., Cui, N., Middleton, B., Ackermann, K., Kayser, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402663111 · Cited by 527 · see citing works
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507 · see citing works
Poroyko, V. A., Carreras, A., Khalyfa, A., Khalyfa, A. A., Leone, V., Peris, E., Almendros, I., Gileles-Hillel, A., Qiao, Z., Hubert, N., et al. (2016) · Scientific Reports · doi:10.1038/srep35405 · Cited by 480 · see citing works
Spaeth, A. M., Dinges, D. F., & Goel, N. (2013) · Sleep · doi:10.5665/sleep.2792 · Cited by 457 · see citing works
Self-citationExtreme Dysbiosis of the Microbiome in Critical Illness
McDonald, D., Ackermann, G., Khailova, L., Baird, C., Heyland, D., Kozar, R., Lemieux, M., Derenski, K., King, J., Vis-Kampen, C., et al. (2016) · mSphere · doi:10.1128/msphere.00199-16 · Cited by 426 · see citing works
Deep Sequencing of the Oral Microbiome Reveals Signatures of Periodontal Disease
Liu, B., Faller, L. L., Klitgord, N., Mazumdar, V., Ghodsi, M., Sommer, D. D., Gibbons, T. R., Treangen, T. J., Chang, Y.-C., Li, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037919 · Cited by 411 · see citing works
Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., & Cedernaes, J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.003 · Cited by 324 · cited 2× · see citing works
“A recent study examined the microbiome in humans after sleep restriction and found that beta diversity was not altered by sleep restriction, similar to our results; however, they suggest that the F:B ratio is altered by only 2 d of sleep restriction (45).”
MethodResultGenetic Determinants of Sleep Regulation in Inbred Mice
Franken, P., Malafosse, A., & Tafti, M. (1999) · SLEEP · doi:10.1093/sleep/22.2.155 · Cited by 284 · see citing works
Brinig, M. M., Lepp, P. W., Ouverney, C., Armitage, G. C., & Relman, D. A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.3.1687-1694.2003 · Cited by 221 · see citing works
Novati, A., Roman, V., Cetin, T., Hagewoud, R., den Boer, J. A., Luiten, P. G. M., & Meerlo, P. (2008) · SLEEP · doi:10.1093/sleep/31.11.1579 · Cited by 204 · see citing works
Self-citationIntestinal TM7 bacterial phylogenies in active inflammatory bowel disease
Kuehbacher, T., Rehman, A., Lepage, P., Hellmig, S., Fölsch, U. R., Schreiber, S., & Ott, S. J. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47719-0 · Cited by 190 · see citing works
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
Weljie, A. M., Meerlo, P., Goel, N., Sengupta, A., Kayser, M. S., Abel, T., Birnbaum, M. J., Dinges, D. F., & Sehgal, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417432112 · Cited by 158 · cited 2× · see citing works
“the stress hormone corticosterone (14, 16).”
BackgroundSelf-citationGoel, N., Banks, S., Mignot, E., & Dinges, D. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005874 · Cited by 154 · see citing works
Self-citationToo Little Sleep Gradually Desensitizes the Serotonin 1A Receptor System
Román, V., Walstra, I., Luiten, P. G. M., & Meerlo, P. (2005) · SLEEP · doi:10.1093/sleep/28.12.1505 · Cited by 122 · see citing works
Self-citationEffects of sleep deprivation and exercise on glucose tolerance.
VanHelder, T., Symons, J. D., & Radomski, M. W. (1993) · PubMed · Cited by 119 · see citing works
Sex and race differences in caloric intake during sleep restriction in healthy adults
Spaeth, A. M., Dinges, D. F., & Goel, N. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.086579 · Cited by 118 · see citing works
Self-citation<i>DQB1*0602</i> predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f9615d · Cited by 92 · see citing works
Barf, R. P., Van Dijk, G., Scheurink, A. J. W., Hoffmann, K., Novati, A., Hulshof, H. J., Fuchs, E., & Meerlo, P. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.09.005 · Cited by 77 · see citing works
Self-citationGoel, N., Banks, S., Lin, L., Mignot, E., & Dinges, D. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029283 · Cited by 58 · see citing works
Self-citationBokulich, N. A., Rideout, J. R., Kopylova, E., Bolyen, E. K., Patnode, J., Ellett, Z., McDonald, D. T., Wolfe, B. E., Maurice, C. F., Dutton, R. J., et al. (2015) · doi:10.7287/peerj.preprints.934v2 · Cited by 31 · see citing works
Suppression of Sleep for Mating
Siegel, J. M. (2012) · Science · doi:10.1126/science.1228466 · Cited by 12 · see citing works
Black, L. I., & Gindi, R. M. (2015) · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541 · see citing works
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 535 · see citing works
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529 · see citing works
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works
Gut microbiome diversity is associated with sleep physiology in humans
Smith, R. P., Easson, C., Lyle, S. M., Kapoor, R., Donnelly, C. P., Davidson, E. J., Parikh, E., Lopez, J. V., & Tartar, J. L. (2019) · PLOS ONE · doi:10.1371/journal.pone.0222394 · Cited by 390 · see citing works
Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307 · see citing works
Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F. (2019) · Microorganisms · doi:10.3390/microorganisms7020041 · Cited by 285 · see citing works
Saccharibacteria (TM7) in the Human Oral Microbiome
Bor, B., Bedree, J. K., Shi, W., McLean, J. S., & He, X. (2019) · Journal of Dental Research · doi:10.1177/0022034519831671 · Cited by 228 · see citing works
Xia, Y. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.003 · Cited by 217 · see citing works
The links between the gut microbiome, aging, modern lifestyle and Alzheimer's disease
Askarova, S., Umbayev, B., Masoud, A.-R., Kaiyrlykyzy, A., Safarova, Y., Tsoy, A., Olzhayev, F., & Kushugulova, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00104 · Cited by 208 · see citing works
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 218 · see citing works
Zhu, B., Shi, C., Park, C. G., Zhao, X., & Reutrakul, S. (2019) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.02.002 · Cited by 190 · see citing works
Microbiota and sleep: awakening the gut feeling
Sen, P., Molinero-Perez, A., O’Riordan, K. J., McCafferty, C. P., O’Halloran, K. D., & Cryan, J. F. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.07.004 · Cited by 162 · see citing works
Ma, W., Song, J., Wang, H., Shi, F., Zhou, N., Jiang, J., Xu, Y., Zhang, L., Yang, L., & Zhou, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.006 · Cited by 134 · see citing works
Timing the Microbes: The Circadian Rhythm of the Gut Microbiome
Liang, X., & FitzGerald, G. A. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417729066 · Cited by 132 · see citing works
Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder
Liu, B., Lin, W., Chen, S., Xiang, T., Yang, Y., Yin, Y., Xu, G., Liu, Z., Liu, L., Pan, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01770 · Cited by 132 · see citing works
Grosicki, G. J., Riemann, B. L., Flatt, A. A., Valentino, T. R., & Lustgarten, M. S. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.04.013 · Cited by 121 · see citing works
The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?
Khodor, S. A., Reichert, B., & Shatat, I. F. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00138 · Cited by 120 · see citing works
The interplay between sleep and gut microbiota
Han, M., Yuan, S., & Zhang, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.12.016 · Cited by 120 · see citing works
Kaczmarek, J. L., Thompson, S. V., & Holscher, H. D. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux036 · Cited by 112 · see citing works
O’Connor, G., Jeffrey, E., Madorma, D., Marcillo, A. E., Abreu, M. T., Deo, S. K., Dietrich, W. D., & Daunert, S. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5349 · Cited by 110 · see citing works
Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105 · see citing works
Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis
Duan, L., Wang, B., & Duan, R. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_603_17 · Cited by 106 · see citing works
Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome
Bowers, S. J., Vargas, F., González, A., He, S., Jiang, P., Dorrestein, P. C., Knight, R. D., Wright, K. P., Lowry, C. A., Fleshner, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229001 · Cited by 99 · see citing works
Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome
Liu, Z., Wei, Z.-Y., Chen, J., Chen, K., Mao, X., Liu, Q., Sun, Y., Zhang, Z., Zhang, Y., Zhou, D., et al. (2020) · mSphere · doi:10.1128/msphere.00914-19 · Cited by 96 · see citing works
Maki, K. A., Burke, L., Calik, M. W., Watanabe‐Chailland, M., Sweeney, D., Romick‐Rosendale, L. E., Green, S. J., & Fink, A. M. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2020 · Cited by 96 · see citing works
Zheng, M., Ye, H., Yang, X., Shen, L., Dang, X., Liu, X., Gong, Y., Wu, Q., Wang, L., Ge, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.016 · Cited by 89 · see citing works
Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality
Zhang, Q., Yun, Y., An, H., Zhao, W., Ma, T., Wang, Z., & Yang, F. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.645045 · Cited by 90 · see citing works
The gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions
Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 88 · see citing works
Gut microbiota: A new target of traditional Chinese medicine for insomnia
Feng, W., Yang, Z., Liu, Y., Chen, R., Song, Z., Pan, G., Zhang, Y., Guo, Z., Ding, X., Chen, L., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114344 · Cited by 85 · see citing works
Li, Y., Shao, L., Mou, Y., Zhang, Y., & Ping, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1957407 · Cited by 81 · see citing works
The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review
dos Santos, A., & Galié, S. (2024) · Nutrients · doi:10.3390/nu16030390 · Cited by 81 · see citing works
St‐Onge, M., & Zuraikat, F. M. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0772-z · Cited by 74 · see citing works
Wei, Y., Xu, J., Miao, S., Wei, K., Peng, L., Wang, Y., & Wei, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2048291 · Cited by 73 · see citing works
Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults
Goel, N. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0799-x · Cited by 74 · see citing works
Self-citationFarré, N., Farré, R., & Gozal, D. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.001 · Cited by 71 · see citing works
Bile acid receptors and signaling crosstalk in the liver, gut and brain
Ferrell, J. M., & Chiang, J. Y. L. (2021) · Liver Research · doi:10.1016/j.livres.2021.07.002 · Cited by 69 · see citing works
Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions
Ieșanu, M. I., Zahiu, C. D. M., Dogaru, I.-A., Chiţimuș, D. M., Pîrcălăbioru, G. G., Voiculescu, S. E., Isac, S., Galoş, F., Pavel, B., O’Mahony, S. M., et al. (2022) · Antioxidants · doi:10.3390/antiox11112244 · Cited by 60 · see citing works
Triplett, J. C., Ellis, D., Braddock, A., Roberts, E., Ingram, K., Perez, E., Short, A. Y., Brown, D., Hutzley, V., Webb, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1701352 · Cited by 57 · see citing works
Sleep and circadian disruption and the gut microbiome-possible links to dysregulated metabolism
Withrow, D., Bowers, S. J., Depner, C. M., González, A., Reynolds, A. C., & Wright, K. P. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.11.009 · Cited by 58 · see citing works
Alterations of the Gut Microbiota in Response to Total Sleep Deprivation and Recovery Sleep in Rats
Wang, Z., Yuan, K., Ji, Y.-B., Li, S.-X., Shi, L., Wang, Z., Zhou, X.-Y., Bao, Y.-P., Xie, W., Han, Y., et al. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s334985 · Cited by 56 · see citing works
The Oscillating Gut Microbiome and Its Effects on Host Circadian Biology
Litichevskiy, L., & Thaiss, C. A. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-111321 · Cited by 56 · see citing works
Wang, Y., Du, W., Hu, X., Yu, X., Guo, C., Jin, X., & Wang, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.009 · Cited by 56 · see citing works
Shimizu, Y., Yamamura, R., Yokoi, Y., Ayabe, T., Ukawa, S., Nakamura, K., Okada, E., Imae, A., Nakagawa, T., Tamakoshi, A., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190306 · Cited by 53 · see citing works
A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota
Aidy, S. E., Bolsius, Y. G., Raven, F., & Havekes, R. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12920 · Cited by 50 · see citing works
Microbiome-Metabolome Signature of Acute Kidney Injury
Andrianova, N. V., Popkov, V. A., Klimenko, N. S., Tyakht, A., Baydakova, G., Frolova, O. Y., Zorova, L. D., Pevzner, I. B., Zorov, D. B., & Plotnikov, E. Y. (2020) · Metabolites · doi:10.3390/metabo10040142 · Cited by 50 · see citing works
Butyrate Ameliorates Insufficient Sleep-Induced Intestinal Mucosal Damage in Humans and Mice
Gao, T., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02000-22 · Cited by 52 · see citing works
Haimov, I., Magzal, F., Tamir, S., Lalzar, M., Asraf, K., Milman, U., Agmon, M., & Shochat, T. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s377114 · Cited by 41 · see citing works
Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice
Gao, T., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2020) · The Journal of Microbiology · doi:10.1007/s12275-020-0094-4 · Cited by 38 · see citing works
Gao, T., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111894 · Cited by 37 · see citing works
Sleep and Circadian Hygiene and Inflammatory Bowel Disease
Swanson, G. R., & Burgess, H. J. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.014 · Cited by 36 · see citing works
Habitual Sleep Duration and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Pilot Study
Agrawal, R., Ajami, N. J., Malhotra, S., Chen, L., White, D. L., Sharafkhaneh, A., Hoffman, K. L., Graham, D. Y., El‐Serag, H. B., Petrosino, J. F., et al. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3030025 · Cited by 37 · see citing works
Karl, J. P., Whitney, C. C., Wilson, M. A., Fagnant, H. S., Radcliffe, P. N., Chakraborty, N., Campbell, R., Hoke, A. V., Gautam, A., Hammamieh, R., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27463-0 · Cited by 32 · see citing works
Holzhausen, E. A., Peppard, P. E., Sethi, A. K., Safdar, N., Malecki, K. M. C., Schultz, A., Deblois, C. L., & Hagen, E. W. (2023) · SLEEP · doi:10.1093/sleep/zsad300 · Cited by 32 · see citing works
López-Santamarina, A., Mondragón, A. D. C., Cardelle‐Cobas, A., Santos, E. M., Porto-Arias, J. J., Cepeda, A., & Miranda, J. M. (2023) · Nutrients · doi:10.3390/nu15133070 · Cited by 33 · see citing works
Bermingham, K. M., Stensrud, S., Asnicar, F., Valdes, A. M., Franks, P. W., Wolf, J., Hadjigeorgiou, G. M., Davies, R., Spector, T. D., Segata, N., et al. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03204-x · Cited by 30 · see citing works
The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation
Chen, H.-W., Zhou, R., Cao, B., Liu, K., Zhong, Q., Huang, Y., Liu, H., Zhao, J.-Q., & Wu, X. (2023) · The EPMA Journal · doi:10.1007/s13167-023-00345-1 · Cited by 31 · see citing works
Luković, E., Moitra, V. K., & Freedberg, D. E. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000734 · Cited by 30 · see citing works
Lee, C., Liang, F., Lee, I., Lu, T., Shan, Y., Jeng, C., Zou, Y., Yu, H., & Chen, S. (2022) · EMBO Reports · doi:10.15252/embr.202052316 · Cited by 29 · see citing works
Liu, D., Wang, Q., Li, Y., Yuan, Z., Liu, Z., Guo, J., Li, X., Zhang, W., Tao, Y., & Mei, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1167312 · Cited by 30 · see citing works
Gut microbiota alterations in response to sleep length among African-origin adults
Fei, N., Choo-Kang, C., Reutrakul, S., Crowley, S. J., Rae, D. E., Bedu-Addo, K., Plange‐Rhule, J., Forrester, T., Lambert, E. V., Bovet, P., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255323 · Cited by 30 · see citing works
Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study
Balnis, J., Madrid, A., Drake, L. A., Vancavage, R., Tiwari, A., Patel, V., Ramos, R. B., Schwarz, J. J., Yucel, R. M., Singer, H. A., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105251 · Cited by 27 · see citing works
Morwani‐Mangnani, J., Giannos, P., Belzer, C., Beekman, M., Slagboom, P. E., & Prokopidis, K. (2022) · SLEEP · doi:10.1093/sleep/zsac239 · Cited by 27 · see citing works
Reutrakul, S., So-ngern, A., Chirakalwasan, N., Saetung, S., Chanprasertyothin, S., Thakkinstian, A., & Chlipala, G. E. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.08.022 · Cited by 24 · see citing works
Zhang, Y., Cheng, L., Liu, Y., Wu, Z., & Weng, P. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1934007 · Cited by 24 · see citing works
Xiang, Q., Liu, Y., Wu, Z., Wang, R., & Zhang, X. (2023) · Food Frontiers · doi:10.1002/fft2.199 · Cited by 27 · see citing works
Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases
Pala, B., Pennazzi, L., Nardoianni, G., Fogacci, F., Cicero, A. F. G., Renzo, L. D., Barbato, E., & Tocci, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113254 · Cited by 23 · see citing works
Zhanfeng, N., Wu, L., Kang, J., Bai, J., Chen, Y., & Hechun, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.934822 · Cited by 23 · see citing works
Tanaka, A., Sanada, K., Miyaho, K., Tachibana, T., Kurokawa, S., Ishii, C., Noda, Y., Nakajima, S., Fukuda, S., Mimura, M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0296047 · Cited by 24 · see citing works
Huang, H., Luo, Z., Min, J., Luo, W., Zhou, X., & Wang, C. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114910 · Cited by 23 · see citing works
Estaki, M., Langsetmo, L., Shardell, M. D., Mischel, A. K., Jiang, L., Zhong, Y., Kaufmann, C. N., Knight, R. D., Stone, K. L., & Kado, D. M. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad011 · Cited by 22 · see citing works
Álvarez‐Herms, J., González, A., Corbi, F., Odriozola, I., & Odriozola, A. (2023) · AIMS Public Health · doi:10.3934/publichealth.2023049 · Cited by 19 · see citing works
The gut microbiota and nervous system: Age-defined and age-defying
Madison, A. A., & Kiecolt‐Glaser, J. K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.12.009 · Cited by 19 · see citing works
Caffeine-Induced Sleep Restriction Alters the Gut Microbiome and Fecal Metabolic Profiles in Mice
Song, Z., Liu, L., Xu, Y., Cao, R., Lan, X., Pan, C., Zhang, S., & Zhao, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314837 · Cited by 18 · see citing works
Self-citationLi, L., Yi, Y., Yan, R., Hu, R., Sun, W., Zhou, W., Zhou, H., Si, X., Ye, Y., Li, W., et al. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1394929 · Cited by 17 · see citing works
The new science of sleep: From cells to large-scale societies
Sharon, O., Simon, E. B., Shah, V. D., Desel, T., & Walker, M. P. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002684 · Cited by 17 · see citing works
Novel concepts in sleep regulation
Wigren, H., & Porkka‐Heiskanen, T. (2017) · Acta Physiologica · doi:10.1111/apha.13017 · Cited by 18 · see citing works
Carrot-based fermentation juice rich in sleep-promoting components improved sleep in mice
Liu, D., Zhang, J., Chen, J., Zhang, C., Yi, H., & Liu, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1043055 · Cited by 16 · see citing works
Targeting microbiota to alleviate the harm caused by sleep deprivation
Chen, H., Wang, C., Bai, J., Song, J., Bu, L., Ming, L., & Suo, H. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127467 · Cited by 15 · see citing works
The impact of plant-rich diets on sleep: a mini-review
Polianovskaia, A., Jonelis, M. B., & Cheung, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1239580 · Cited by 17 · see citing works
Zhang, J., Zhang, X., Zhang, K., Lu, X., Yuan, G., Yang, H., Guo, H., Zhu, Z., Wang, T., Hao, J., et al. (2022) · Polish Journal of Microbiology · doi:10.33073/pjm-2022-021 · Cited by 15 · see citing works
Effect of a probiotic fermented milk supplementation on behavior and sleep
de Freitas, S., Franco, B., Saragiotto, G. K., de Morais, M. A., Simabuco, F. M., da Cunha, D. T., Esteves, A. M., & Antunes, A. E. C. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2240990 · Cited by 14 · see citing works
Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation
Singh, A., & Negi, P. S. (2025) · Journal of Food Science · doi:10.1111/1750-3841.17634 · Cited by 14 · see citing works
Bijnens, S., & Depoortere, I. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114103 · Cited by 16 · see citing works
The association between gut microbiota and insomnia: A systematic review and meta-analysis
Chen, S., Li, H., Ning, M., Yu, B. Y. M., Wu, S., Cheng, W.-Y., Li, Y., & Yeung, W.-F. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102236 · Cited by 13 · see citing works
Lee, J., Lee, J., Kang, J., Kim, Y., Lee, S., & Kim, T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1117259 · Cited by 14 · see citing works
Shirolapov, I. V., Витальевна, Г. О., Kovalev, A. M., Shafigullina, L. R., Ulivanova, V. A., Kozlov, A. V., Еreshchenko, A. A., Lyamin, A. V., & Zakharov, A. V. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202412405279 · Cited by 13 · see citing works
Yao, T., Chao, Y., Huang, C.-M., Lee, H., Liu, C.-Y., Li, K.-W., Hsu, A., Tung, Y., & Wu, C. W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1503176 · Cited by 13 · see citing works
Triplett, J. C., Braddock, A., Roberts, E., Ellis, D. H., & Chan, V. (2022) · Sleep Science · doi:10.5935/1984-0063.20200116 · Cited by 12 · see citing works
Zhao, C., Kelly, K., Jabbur, M. L., Paguaga, M. E., Behringer, M. G., & Johnson, C. H. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001865 · Cited by 11 · see citing works
Carpena, M. X., Barros, A. J. D., Comelli, E. M., López-Domínguez, L., Alves, E. D., Wendt, A. T., Crochemore‐Silva, I., Bandsma, R., Santos, I. S., Matijasevich, A., et al. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2023.12.028 · Cited by 10 · see citing works
Barak, N., Fadeev, E., Brekhman, V., Aharonovich, D., Lotan, T., & Sher, D. (2023) · Microorganisms · doi:10.3390/microorganisms11040955 · Cited by 10 · see citing works
Gut microbiota and circadian disruption in humans: Is there a rationale for metabolic disorders?
Romanenko, M., Bartsch, M., Півень, Л. В., Hahn, A., & Müller, M. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2536521 · Cited by 10 · see citing works
Savvidis, C., Maggio, V., Rizzo, M., Zabulienė, L., & Ilias, Ι. (2025) · Medicina · doi:10.3390/medicina61091630 · Cited by 12 · see citing works
Sanford, L. D., Wellman, L. L., Ciavarra, R. P., Oldfield, E. C., Shams, R., Copare, J., & Johnson, D. A. (2021) · Life · doi:10.3390/life11121283 · Cited by 9 · see citing works
Myers, B. A., Reddy, V. D., Brownstone, N. D., Chan, S. Y., Thibodeaux, Q. G., Chang, H.-W., Bhutani, T., & Liao, W. J. (2020) · Journal of Psoriasis and Psoriatic Arthritis · doi:10.1177/2475530320964781 · Cited by 9 · see citing works
Zheng, L.-M., & Li, Y. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s476691 · Cited by 8 · see citing works
Lin, W., Yang, Y., Zhu, Y., Pan, R., Liu, C., & Pan, J. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s472675 · Cited by 10 · see citing works
- Authors
- Zhang, S. L., Bai, L., Goel, N., Bailey, A., Jang, C. J., Bushman, F. D., Meerlo, P., Dinges, D. F., & Sehgal, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Pennsylvania (US)
- University of Groningen (NL)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-08
- Volume
- 114
- Issue
- 8
- Pages
- E1564-E1571
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5338418
- OpenAlex
- W2586552311
- Semantic Scholar
- 0f4c0871629e2f2802bd6e70905efdaad3e80b8a
- Cited by
- 139
- References
- 50
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 18 · 2023: 22 · 2022: 23 · 2021: 18 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 6
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute (R25MH060490)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (T32HL07713)
- Children's Hospital of Philadelphia (P30 AI 045008)
- DOD | Office of Naval Research (N00014-11-1-0361)
- National Aeronautics and Space Administration (NNX14AN49G)
- HHS | NIH | National Institute of Nursing Research (R01 NR004281)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- gut microbiota, sleep restriction, insufficient sleep, microbiota composition, cross-species comparison, rats, human, 16S rRNA, operational taxonomic units, metabolic disorders
- MeSH terms
- Gastrointestinal Microbiome, Adult, Animals, Cognition, DNA, Bacterial, Feces, Female, Humans, Male, Metabolic Diseases, Middle Aged, RNA, Ribosomal, 16S, Sleep Deprivation, Rats, Sprague-Dawley, Genes, rRNA, Gastrointestinal Tract, Rats, Healthy Volunteers, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
