Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice
Open accessAbstract
Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.
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Depletion of Akkermansia muciniphila is linked to disrupted intestinal permeability and increased plasma lipopolysaccharide, causing systemic inflammation and MAFLD in mice.
“Depletion of A. muciniphila has been linked to disrupted intestinal permeability and increased plasma lipopolysaccharide (LPS), causing systemic inflammation and MAFLD in mice (Shi et al., 2021).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Shi et al., 2021
The Discussion (page not available) links A. muciniphila depletion in sweetener-treated mice to impaired intestinal barrier integrity, elevated serum LPS, systemic inflammatory signaling, and fatty liver disease. It describes the inflammatory pathway as suggested by the findings, rather than establishing that depletion alone caused it. The paper calls the liver disease NAFLD, not MAFLD. (LLM, conf=0.83)
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- Authors
- Shi, Z., Lei, H., Chen, G., Yuan, P., Cao, Z., Ser, H.-L., Zhu, X., Wu, F., Liu, C., Dong, M., Song, Y., Guo, Y., Chen, C., Hu, K., Zhu, Y., Zeng, X.-A., Zhou, J., Lu, Y., Patterson, A. D., & Zhang, L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Guangdong University of Technology (CN)
- South China University of Technology (CN)
- Engineering Research Academy of High Value Utilization of Green Plants, Meizhou, China
- School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China
- Pennsylvania State University (US)
- Corresponding author
- Zhang, Limin
- ORCID
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2021-02-23
- Volume
- 6
- Issue
- 1
- ISSN
- 2379-5077 (ISSN-L)
- PMC
- PMC8573958
- OpenAlex
- W3130889309
- Cited by
- 71
- References
- 59
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 13 · 2023: 16 · 2022: 13 · 2021: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- mSystems (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Foshan Core Technology Tackling Key Project (1920001000262)
- National Key Research and Development Project (2018YFE0110800)
- China Postdoctoral Science Foundation (2019M662893)
- National Natural Science Foundation of China (21635006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- Akkermansia muciniphila, aryl hydrocarbon receptor ligands, non-alcoholic fatty liver disease, gut-liver axis, saccharin, sucralose, artificial sweeteners, metformin, fructooligosaccharides, neohesperidin dihydrochalcone, free sugars, gut microbiota
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