Low-polarity phytoecdysteroids from the juice of Serratula coronata L. (Asteraceae)
Abstract
Eleven phytoecdysteroids have been isolated and identified from the low polarity fractions of Serratula coronata juice by a combination of column chromatography and HLPC. Four of them are new, i.e. ecdysone 22-acetate 7, (25S)-inokosterone 26-acetate 9, 20,22-O-(R-ethylidene)-20-hydroxyecdysone 10 and 20,22-O-(R-ethylidene)-ajugasterone C 11. The biological activity of these new ecdysteroids in the Drosophila melanogaster BII cell bioassay is reported.
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Compounds 64-68 showed agonistic activity in the Drosophila BII cell bioassay with EC50 values of 16, 1.1, 0.6, 43, and 62 μmol/L.
“EC50 16, 1.1, 0.6, 43, and 62 μmol/L”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [71]
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The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
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- Authors
- Odinokov, V. N., Kumpun, S., Galyautdinov, I. V., Evrard-Todeschi, N., Veskina, N. A., Khalilov, L. M., Girault, J.-P., Dinan, L., Maria, A., & Lafont, R.
- Affiliations
- Ramkhamhaeng University (TH)
- Russian Academy of Sciences (RU)
- Centre National de la Recherche Scientifique (FR)
- University of Exeter (GB)
- Venue
- Collection of Czechoslovak Chemical Communications
- Published
- 2005
- Volume
- 70
- Issue
- 12
- Pages
- 2038-2052
- ISSN
- 0010-0765 (ISSN-L)
- 1212-6950
- OpenAlex
- W2065069234
- Cited by
- 23
- References
- 26
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2013: 1 · 2012: 14
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Collection of Czechoslovak Chemical Communications (publishedVersion)
- Digitalni Knihovna - Knihovna Akademie věd ČR (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- phytoecdysteroids, Serratula coronata, Asteraceae, insect growth regulators, plant juice
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