Altered arousal response in infants exposed to cigarette smoke
Open accessAbstract
AIMS: A failure of the arousal mechanism is a key feature in the apnoea theory for sudden infant death syndrome (SIDS). In infants studied at an age when the incidence of SIDS is highest, we evaluated whether in utero smoke exposed infants have altered arousal response to standardised auditory stimuli, and/or sleep pattern, as recorded on overnight complex sleep polysomnography. METHODS: A standardised sequence of audiology stimuli was applied binaurally to 20 in utero smoke and non-smoke exposed infants aged 8-12 weeks during a rapid eye movement (REM) and NREM epoch, in a controlled (temperature, position, pacifier use, noise) sleep environment. Infants were monitored for 10-12 hours using complex sleep polysomnography. RESULTS: Five infants exposed to in utero tobacco smoke did not have behavioural arousal response, whereas all non-smoke exposed infants aroused during NREM (p = 0.016). There was, however, no difference in REM sleep, and the groups did not differ in routine overnight complex sleep polysomnography parameters. CONCLUSION: At the age when the incidence of SIDS is at its peak, infants of smoking mothers are less rousable than those of non-smoking mothers in NREM sleep; this may partly explain why such infants are more at risk of SIDS.
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Tobacco exposure during pregnancy impairs infant cardiorespiratory function.
“Maternal smoking and smokeless tobacco use during pregnancy are associated with increased risk of neonatal apnea, while maternal smoking is also associated with a decreased arousal response.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [118]
Maternal smoking is associated with a reduced arousal response.
“while maternal smoking is also associated with a decreased arousal response.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [118]
Maternal smoking and smokeless tobacco use during pregnancy are associated with increased neonatal apnea.
“Maternal smoking and smokeless tobacco use during pregnancy are associated with increased risk of neonatal apnea”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [118]
Cites
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183 · see citing works
Standards and Indications for Cardiopulmonary Sleep Studies in Children. American Thoracic Society
(1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564147 · Cited by 1,178 · see citing works
Blair, P. S., Fleming, P., Bensley, D., Smith, I., Bacon, C., Taylor, E. M., Berry, J., Golding, J., & Tripp, J. H. (1996) · BMJ · doi:10.1136/bmj.313.7051.195 · Cited by 356 · see citing works
Smoking and the Sudden Infant Death Syndrome
Mitchell, E. A., Ford, R. P. K., Stewart, A., Taylor, B. J., Becroft, D. M. O., Thompson, J., Scragg, R. K. R., Hassall, I. B., Barry, D. M., Allen, E. M., et al. (1993) · PEDIATRICS · doi:10.1542/peds.91.5.893 · Cited by 284 · see citing works
Kahn, A., Groswasser, J., Rebuffat, E., Sottiaux, M., Blum, D. L., Foerster, M., Franco, P., Bochner, A., Alexander, M., Bachy, A., et al. (1992) · SLEEP · doi:10.1093/sleep/15.4.287 · Cited by 277 · see citing works
Arousal pattern following central and obstructive breathing abnormalities in infants and children
McNamara, F., Issa, F. G., & Sullivan, C. E. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.6.2651 · Cited by 212 · see citing works
Lewis, K., & Bosque, E. M. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70155-9 · Cited by 205 · see citing works
Prenatal exposure to cigarette smoking is associated with a decrease in arousal in infants
Franco, P., Groswasser, J., Hassid, S., Lanquart, J. P., Scaillet, S., & Kahn, A. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70324-0 · Cited by 146 · see citing works
Auditory arousal thresholds are higher when infants sleep in the prone position
Franco, P., Pardou, A., Hassid, S., Lurquin, P., Groswasser, J., & Kahn, A. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70438-x · Cited by 127 · see citing works
Early developmental changes in [3H]nicotine binding in the human brainstem
Kinney, H. C., O'Donnell, T. J., Kriger, P., & White, W. F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90326-b · Cited by 122 · see citing works
Cardiorespiratory adaptation during sleep in infants and children
Gaultier, C. (1995) · Pediatric Pulmonology · doi:10.1002/ppul.1950190206 · Cited by 119 · see citing works
Prenatal exposure to cigarettes in infants with obstructive sleep apneas
Kahn, A., Groswasser, J., Sottiaux, M., Kelmanson, I., Franco, P., Rebuffat, E., Dramaix, M., & Wayenberg, J. L. (1994) · PEDIATRICS · doi:10.1542/peds.93.5.778 · Cited by 117 · see citing works
Respiratory Control Disorders in Infants and Children
Beckerman, R. C., Brouilette, R. T., & Hunt, C. E. (1992) · Medical Entomology and Zoology · Cited by 112 · see citing works
The influence of a pacifier on infants' arousals from sleep
Franco, P., Scaillet, S., Wermenbol, V., Valente, F., Groswasser, J., & Kahn, A. (2000) · The Journal of Pediatrics · doi:10.1016/s0022-3476(00)20580-5 · Cited by 105 · see citing works
Effect of nicotine exposure on postnatal ventilatory responses to hypoxia and hypercapnia
Bamford, O. S., Schuen, J. N., & Carroll, J. L. (1996) · Respiration Physiology · doi:10.1016/0034-5687(96)00051-5 · Cited by 100 · see citing works
Righard, L. (1998) · Birth · doi:10.1046/j.1523-536x.1998.00128.x · Cited by 98 · see citing works
Sudden Infant Death Syndrome and Other Causes of Infant Mortality
Hunt, C. E. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.3.9910045 · Cited by 90 · see citing works
A reexamination of the risk factors for the sudden infant death syndrome
Taylor, J. A., & Sanderson, M. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70202-4 · Cited by 88 · see citing works
Mechanisms Underlying Regulation of Respiratory Pattern by Nicotine in PreBötzinger Complex
Shao, X. M., & Feldman, J. L. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2461 · Cited by 76 · see citing works
Sudden infant death syndrome and parental smoking — a literature review
Golding, J. (1997) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.1997.d01-12.x · Cited by 75 · see citing works
Australia's children: their health and wellbeing 2002
Al-Yaman, F. M., Bryant, M., & Sargeant, H. (2002) · Australian Institute of Health and Welfare eBooks · Cited by 72 · see citing works
Thoman, E. B., & Ingersoll, E. W. (1999) · Child Development · doi:10.1111/1467-8624.00001 · Cited by 67 · see citing works
Paediatric origins of adult lung diseases bullet 4: Tobacco related lung diseases begin in childhood
Souëf, P. N. L. (2000) · Thorax · doi:10.1136/thorax.55.12.1063 · Cited by 58 · see citing works
Ambient Temperature is Associated with Changes in Infants' Arousability from Sleep
Franco, P., Scaillet, S., Ir, F. V., Chabanski, S., Groswasser, J., & Kahn, A. (2001) · SLEEP · doi:10.1093/sleep/24.3.325 · Cited by 55 · see citing works
Schellscheidt, J., φyen, N., & Jorch, G. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb08612.x · Cited by 55 · see citing works
Dynamic Changes in Arousal Threshold during Sleep in the Human Infant
Read, P. A., Horne, R. S. C., Cranage, S. M., WALKER, A. M., Walker, D. W., & Adamson, T. M. (1998) · Pediatric Research · doi:10.1203/00006450-199805000-00020 · Cited by 55 · see citing works
Mechanism of the suddent infant death syndrome?
NEWMAN, N. M., Trinder, J. A., PHILLIPS, K., JORDAN, K., & CRUICKSHANK, J. (1989) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1989.tb01454.x · Cited by 55 · see citing works
Nicotine exposure and the risk of SIDS
Milerad, J., & Sundell, H. (1993) · Acta Paediatrica · doi:10.1111/j.1651-2227.1993.tb12882.x · Cited by 48 · see citing works
Reduced Arousals Following Obstructive Apneas in Infants Sleeping Prone
Groswasser, J., Simon, T., Scaillet, S., Franco, P., & Kahn, A. (2001) · Pediatric Research · doi:10.1203/00006450-200103000-00015 · Cited by 45 · see citing works
Habituation of the Infant Arousal Response
McNamara, F., Wulbrand, H., & Thach, B. T. (1999) · SLEEP · doi:10.1093/sleep/22.3.320 · Cited by 45 · see citing works
Ventilatory sensitivity to mild asphyxia: prone versus supine sleep position
Galland, B. C. (2000) · Archives of Disease in Childhood · doi:10.1136/adc.83.5.423 · Cited by 41 · see citing works
Thach, B. T., & Lijowska, A. S. (1996) · SLEEP · doi:10.1093/sleep/19.suppl_10.s271 · Cited by 37 · see citing works
Environmental Tobacco Smoke and Otitis Media
Gulya, A. J. (1994) · Otolaryngology · doi:10.1177/019459989411100103 · Cited by 34 · see citing works
Trinder, J. C., Newman, N. M., Grande, M. R. L., Whitworth, F. A., Kay, A., Pirkis, J., & Jordan, K. (1990) · Biological Psychology · doi:10.1016/0301-0511(90)90035-u · Cited by 31 · see citing works
Clinical versus polysomnographic profiles in children with obstructive sleep apnoea
Masters, I. B., Harvey, J., Wales, P., O'Callaghan, M. J., & Harris, M. (1999) · Journal of Paediatrics and Child Health · doi:10.1046/j.1440-1754.1999.00336.x · Cited by 29 · see citing works
Raised bile acid concentrations in SIDS lungs at necropsy
Hills, B. A., Chen, Y., Masters, I. B., et al. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.2.120 · Cited by 24 · see citing works
Age‐related changes in oxygen saturation over the first year of life: A longitudinal study
Masters, I. B., GOES, A. M., HEALY, L., et al. (1994) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1994.tb00693.x · Cited by 21 · see citing works
Potter, A., Lumley, J., & Watson, L. (1996) · Early Human Development · doi:10.1016/0378-3782(96)01726-4 · Cited by 20 · see citing works
Predictors of cost-related outcomes of neonatal intensive care
Lewis, S. R. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70140-0 · Cited by 3 · see citing works
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Moon, R. Y., TASK FORCE ON SUDDEN INFANT DEATH SYNDROME, Darnall, R. A., Feldman-Winter, L., Goodstein, M. H., & Hauck, F. R. (2016) · Pediatrics · doi:10.1542/peds.2016-2940 · Cited by 583 · see citing works
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Spindel, E. R., & McEvoy, C. T. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201510-2013pp · Cited by 154 · see citing works
Kinney, H. C. (2009) · Developmental Psychobiology · doi:10.1002/dev.20367 · Cited by 121 · see citing works
The effect of maternal smoking on respiratory and arousal patterns in preterm infants during sleep
Sawnani, H., Jackson, T., Murphy, T., Beckerman, R., & Simakajornboon, N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200305-692oc · Cited by 90 · see citing works
Maternal smoking impairs arousal patterns in sleeping infants
Richardson, H. L., Walker, A. M., & Horne, R. S. C. (2009) · SLEEP · doi:10.1093/sleep/32.4.515 · Cited by 77 · see citing works
Influences of maternal cigarette smoking on infant arousability
Horne, R. S. C., Franco, P., Adamson, T. M., Groswasser, J., & Kahn, A. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2004.04.005 · Cited by 72 · see citing works
- Authors
- Chang, A. B.
- Affiliations
- The Royal Children's Hospital Foundation (AU)
- Corresponding author
- Chang, A B
- ORCID
- Chang, A B
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 2003-01-01
- Volume
- 88
- Issue
- 1
- Pages
- 30-33
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC1719296
- OpenAlex
- W2068956235
- Cited by
- 75
- References
- 39
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Disease in Childhood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- sudden infant death syndrome, maternal smoking, NREM sleep, REM sleep, sleep architecture, auditory stimuli
- MeSH terms
- Adult, Arousal, Female, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Sudden Infant Death, Case-Control Studies, Polysomnography
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