Does dietary lutein and zeaxanthin increase the risk of age related macular degeneration? The Melbourne Visual Impairment Project
Open accessAbstract
Age related macular degeneration (AMD) was one of the five main causes of vision impairment in the combined study of the Melbourne Visual Impairment Project (MVIP) and the Blue Mountains Eye Study (BMES).1 A higher dietary intake of lutein/zeaxanthin was significantly associated with lower risk of having exudative age related macular degeneration in the Eye Disease Case-Control Study, but there was no association between lutein/zeaxanthin (LZ) intake and either early or neovascular age related maculopathy in the combined prospective US study.2,3 Also, a higher fish intake has been associated with a lower risk of progression to advanced AMD among those with low (below median) linoleic acid intake, whereas there was no significant association among those with higher linoleic acid intake.4 The aim of this paper is to examine the association of AMD with dietary intake of the carotenoids lutein/zeaxanthin in conjunction with linoleic acid intake in the follow up population based sample of the MVIP. ### Study design Of 3040 permanent residents recruited in 1992–4, 2594 (85%) of them attended the follow up examinations in 1997–9.5 At both time points of the study, participants signed an informed consent and underwent a standard procedure including an ophthalmic examination and an interview regarding socioeconomic and demographic characteristics, historic and current symptoms of eye diseases, medical history, and medication use. The follow up survey also included a …
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Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.
“Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.90–95”
From Age-related macular degeneration (2008) · cites this paper as [95]
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Age-related macular degeneration
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Dietary lutein and zeaxanthin: authors' response
Robman, L. D. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.097444
- Authors
- Vu, H. T. V.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Vu, H T V
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2006-03-01
- Volume
- 90
- Issue
- 3
- Pages
- 389-390
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1856932
- OpenAlex
- W1977929793
- Cited by
- 18
- References
- 14
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 1 · 2012: 2
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- David and Elaine Potter Foundation
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, lutein, zeaxanthin, dietary carotenoids, linoleic acid, dietary intake, neovascular age-related macular degeneration, visual impairment
- MeSH terms
- Aged, Diet, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Lutein, beta Carotene, Linoleic Acid, Xanthophylls, Zeaxanthins
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