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Cited by 96Retinal Diseases and TreatmentsRetinal Imaging and AnalysisOcular Diseases and Behçet’s Syndrome

Five-year incidence of age-related maculopathy*1The Visual Impairment Project

MUKESH, B·2004·Ophthalmology
DOI 10.1016/j.ophtha.2003.08.042
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Abstract

Purpose To describe the 5-year incidence of age-related maculopathy (ARM) and the progression of the early stages of ARM lesions in Melbourne, Australia.Design Population-based cohort study.Participants A total of 3271 participants aged 40 years and older from Melbourne, Victoria, Australia.Main outcome measures The 5-year incidence and progression of ARM lesions.Methods Participants were recruited through a cluster random sampling from 9 urban clusters. Baseline examinations were conducted from 1992 through 1994, and the follow-up data were collected from 1997 through 1999. Presence of ARM lesions was graded from color stereo fundus photographs according to the International Classification and Grading System.Results The overall cumulative 5-year incidence of age-related macular degeneration (AMD) was 0.49% (95% confidence interval [CI], 0.2-0.8) and that of early ARM was 17.3% (95% CI, 8.7-26.0). The incidence of all ARM lesions increased with age (all P<0.001). The 5-year incidence of AMD was 0%, 0.69%, 1.7%, and 6.3% and that of early ARM was 13%, 22.7%, 29.8%, and 20% for participants aged 60 years and younger, aged 60 to 69 years, aged 70 to 79 years, and aged 80 years and older at baseline, respectively. People with soft indistinct drusen with pigmentary abnormalities had a 9.5 times (95% CI, 1.9-45.6) higher risk of developing AMD compared with people with soft drusen or pigmentary abnormalities. After adjusting for age, people with unilateral early ARM at baseline were 3 times (95% CI, 0.98-8.0) as likely to have early ARM in their second eye when compared with people with no ARM in both eyes.Conclusions These data suggest that 1 in 3 persons aged 70 years or older will have ARM lesions over a 5-year period and that the disease will progress to a more severe form after the age of 80 years. The presence of soft indistinct drusen with pigmentary abnormalities significantly increased the risk for development of AMD.

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  • Age-related macular degeneration is more common in white individuals than in people of other ethnic origin.

    “Age-related macular degeneration is more common in white individuals than in people of other ethnic origin.21,41,42”

    From Age-related macular degeneration (2008) · cites this paper as [21]

  • The 5-year progression rate to advanced age-related macular degeneration in the Visual Impairment Project from Melbourne, Australia, ranged from 0% in people aged 60 years and younger to 6.3% in those 80 years and older.

    “The 5-year progression rate to advanced age-related macular degeneration in another population-based study—the Visual Impairment Project from Melbourne, Australia—ranged from 0% in people aged 60 years and younger to 6·3% in those 80 years and older.21”

    From Age-related macular degeneration (2008) · cites this paper as [21]

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Authors
MUKESH, B.
Affiliations
The University of Melbourne (AU)
Corresponding author
MUKESH, B
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2004-06
Volume
111
Issue
6
Pages
1176-1182
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2003.08.042
OpenAlex
W92737290
Cited by
96
References
24
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 7
FWCI
9.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
age-related macular degeneration, incidence, disease progression, drusen, pigmentary abnormalities, older adults
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Macular Degeneration, Male, Middle Aged, Photography, Risk Factors, Victoria, Cohort Studies, Incidence, Age Distribution, Sex Distribution

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