The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Increased expression of angiogenic growth factors in age-related maculopathy
Open accessAbstract
AIMS/BACKGROUND: The late stages of age-related maculopathy (ARM), especially neovascular macular degeneration (ARMD), can severely affect central vision and are the main cause of blindness in the elderly in the Western world. It has been shown that angiogenic growth factors are present in neovascular membranes in ARMD. However, it is not known if angiogenic growth factors play a role in the onset of neovascularisation. METHODS: In order to elucidate the involvement of angiogenic growth factors in the initiation of neovascularisation in early stages of ARM, the expression patterns of VEGF, TGF-beta, b-FGF, and PDGF-AA on 18 human maculae with ARM, and on 11 control specimens were investigated immunohistochemically. RESULTS: A significantly increased expression of VEGF (p = 0.00001) and TGF-beta (p = 0.019) was found in the retinal pigment epithelium (RPE) of maculae with ARM compared with control maculae. Furthermore, an increased expression of VEGF and PDGF was found in the outer nuclear layer of maculae with ARM. CONCLUSION: These results demonstrate an increased expression of VEGF in the RPE, and in the outer nuclear layer in maculae with ARM, that could be involved in the pathogenesis of neovascular macular degeneration. Furthermore, enhanced TGF-beta expression in the RPE cells of maculae with early stages of ARM was shown.
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Cited by
Ranibizumab for Neovascular Age-Related Macular Degeneration
Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., & Kim, R. Y. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054481 · Cited by 5,886
The Retinal Pigment Epithelium in Visual Function
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Current concepts in the pathogenesis of age-related macular degeneration
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Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
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Vascular endothelial growth factors and angiogenesis in eye disease
Witmer, A. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00043-5 · Cited by 927
Metadata
- Authors
- Kliffen, M., Sharma, H. S., Mooy, C. M., Kerkvliet, S., & de Jong, P. T. V. M.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1997-02-01
- Volume
- 81
- Issue
- 2
- Pages
- 154-162
- ISSN
- 0007-1161 (ISSN-L)
- OpenAlex
- W2051842051
- Cited by
- 502
- References
- 57
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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