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Cited by 195Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentChild Abuse and Trauma

In Search of HPA Axis Dysregulation in Child and Adolescent Depression

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Guerry, John D., Hastings, Paul D.·2011·Clinical Child and Family Psychology Review
DOI 10.1007/s10567-011-0084-5PMC PMC3095794
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Abstract

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in adults with major depressive disorder is among the most consistent and robust biological findings in psychiatry. Given the importance of the adolescent transition to the development and recurrence of depressive phenomena over the lifespan, it is important to have an integrative perspective on research investigating the various components of HPA axis functioning among depressed young people. The present narrative review synthesizes evidence from the following five categories of studies conducted with children and adolescents: (1) those examining the HPA system's response to the dexamethasone suppression test (DST); (2) those assessing basal HPA axis functioning; (3) those administering corticotropin-releasing hormone (CRH) challenge; (4) those incorporating psychological probes of the HPA axis; and (5) those examining HPA axis functioning in children of depressed mothers. Evidence is generally consistent with models of developmental psychopathology that hypothesize that atypical HPA axis functioning precedes the emergence of clinical levels of depression and that the HPA axis becomes increasingly dysregulated from child to adult manifestations of depression. Multidisciplinary approaches and longitudinal research designs that extend across development are needed to more clearly and usefully elucidate the role of the HPA axis in depression.

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  • Depressive symptoms are associated with the development of hyporeactive HPA axis responses to stress.

    “depressive symptoms are associated with the development of hyporeactive responses to stress in the HPA axis (see Guerry & Hastings 2011 for a review)”

    From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Guerry & Hastings 2011

    The Psychological Challenge Studies section reports relatively hyporesponsive cortisol reactions to stress in prepubertal children with subclinical depressive symptoms. But it reports hyper-reactivity in post-pubertal dysphoric youths and does not establish that depressive symptoms cause hyporeactive responses to develop. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Guerry, J. D., & Hastings, P. D.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • University of California, Davis (US)
Corresponding author
Guerry, John D.
ORCID
Hastings, Paul D.
Venue
Clinical Child and Family Psychology Review
Publisher
Springer Science and Business Media LLC
Published
2011-02-03
Volume
14
Issue
2
Pages
135-160
ISSN
  • 1096-4037 (ISSN-L)
  • 1573-2827
DOI
10.1007/s10567-011-0084-5
PMC
PMC3095794
OpenAlex
W2017380003
Cited by
195
References
30
Citations by year
2026: 7 · 2025: 17 · 2024: 11 · 2023: 16 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 8 · 2016: 15 · 2015: 18 · 2014: 13 · 2013: 11 · 2012: 9
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Clinical Child and Family Psychology Review (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
hypothalamic-pituitary-adrenal axis, HPA axis dysregulation, childhood depression, adolescent depression, dexamethasone suppression test, developmental psychopathology, maternal depression, children of depressed mothers, longitudinal development
MeSH terms
Adolescent, Adult, Child, Child Development, Corticotropin-Releasing Hormone, Depression, Dexamethasone, Female, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Male, Mothers, Pituitary-Adrenal System, Risk Factors

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