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Cited by 438Dementia and Cognitive Impairment ResearchPalliative Care and End-of-Life IssuesInsurance, Mortality, Demography, Risk Management

Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up

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Xie, Jing, Brayne, Carol, Matthews, Fiona E·2008·BMJ
DOI 10.1136/bmj.39433.616678.25PMC PMC2223023
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Abstract

OBJECTIVES: To provide estimates of survival after onset of dementia by age, sex, self reported health, disability, and severity of cognitive impairment. DESIGN: Analysis of participants from prospective population based cohort study in 1991-2003, with follow-up of dementia status in all individuals after two and six years (in one centre) and 10 years and in subsamples additionally at six and eight years and mortality until 2005. SETTING: Multicentre population based study in England and Wales: two rural and three urban centres. PARTICIPANTS: 438 participants who developed dementia from a population based study of 13 004 individuals aged 65 years and over drawn from primary care population registers. MAIN OUTCOME MEASURES: Sociodemographic factors, cognitive function, specific health conditions, and self reported health collected at each interview. Cox's proportional hazards regression models were used to identify predictors of mortality from the selected variables in people who received diagnosis of dementia according the study's criteria. RESULTS: By December 2005, 356 of the 438 (81%) participants who developed dementia during the study had died. Estimated median survival time from onset of dementia to death was 4.1 years (interquartile range 2.5-7.6) for men and 4.6 years (2.9-7.0) for women. There was a difference of nearly seven years in survival between the younger old and the oldest people with dementia: 10.7 (25th centile 5.6) for ages 65-69; 5.4 (interquartile range 3.4-8.3) for ages 70-79; 4.3 (2.8-7.0) for ages 80-89, and 3.8 (2.3-5.2) years for ages > or =90. Significant factors that predicted mortality in the presence of dementia during the follow-up included sex, age of onset, and disability. CONCLUSION: These analyses give a population based estimated median survival for incident dementia of 4.5 years. Such estimates can be used for prognosis and planning for patients, carers, service providers, and policy makers.

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  • Our findings are consistent with previous work that has demonstrated persons with dementia experience poorer survival and shorter time to long-term care transition than those without dementia, although the magnitude of the differences we show is not as large as in some previous work.

    “Our findings are consistent with previous work that has demonstrated persons with dementia experience poorer survival2 26 and shorter time to long-term care transition than those without dementia,11 however the magnitude of the differences we show is not as large as in some previous work.”

    From Trajectories of health system use and survival for community-dwelling persons with dementia: a cohort study (2020) · cites this paper as [26]

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Authors
Xie, J., Brayne, C., & Matthews, F. E.
Affiliations
  • University of Cambridge (GB)
  • MRC Biostatistics Unit (GB)
Corresponding author
Brayne, Carol
ORCID
Venue
BMJ
Publisher
BMJ
Published
2008-01-10
Volume
336
Issue
7638
Pages
258-262
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.39433.616678.25
PMC
PMC2223023
OpenAlex
W1998893055
Cited by
438
References
2
Citations by year
2026: 19 · 2025: 10 · 2024: 22 · 2023: 9 · 2022: 16 · 2021: 15 · 2020: 57 · 2019: 22 · 2018: 24 · 2017: 27 · 2016: 24 · 2015: 32 · 2014: 33 · 2013: 22 · 2012: 29
FWCI
18.04
Type
journal article
Language
en
Open access
Licence
www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
  • Repository@Hull (Worktribe) (University of Hull) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Social Sciences › Demography › Insurance, Mortality, Demography, Risk Management
Keywords
dementia, mortality, age of onset, sex differences, disability, cognitive impairment severity, self-reported health, older adults, prognosis
MeSH terms
Aged, Aged, 80 and over, Cognition Disorders, Dementia, England, Epidemiologic Methods, Female, Humans, Male, Socioeconomic Factors, Wales, Age of Onset

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