Impact evaluations of drug decriminalisation and legal regulation on drug use, health and social harms: a systematic review
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Objectives: To review the metrics and findings of studies evaluating effects of drug decriminalisation or legal regulation on drug availability, use or related health and social harms globally. Design: Systematic review with narrative synthesis. Data sources: We searched MEDLINE, Embase, PsycINFO, Web of Science and six additional databases for publications from 1 January 1970 through 4 October 2018. Inclusion criteria: Peer-reviewed articles or published abstracts in any language with quantitative data on drug availability, use or related health and social harms collected before and after implementation of de jure drug decriminalisation or legal regulation. Data extraction and synthesis: Two independent reviewers screened titles, abstracts and articles for inclusion. Extraction and quality appraisal (modified Downs and Black checklist) were performed by one reviewer and checked by a second, with discrepancies resolved by a third. We coded study-level outcome measures into metric groupings and categorised the estimated direction of association between the legal change and outcomes of interest. Results: We screened 4860 titles and 221 full-texts and included 114 articles. Most (n=104, 91.2%) were from the USA, evaluated cannabis reform (n=109, 95.6%) and focussed on legal regulation (n=96, 84.2%). 224 study outcome measures were categorised into 32 metrics, most commonly prevalence (39.5% of studies), frequency (14.0%) or perceived harmfulness (10.5%) of use of the decriminalised or regulated drug; or use of tobacco, alcohol or other drugs (12.3%). Across all substance use metrics, legal reform was most often not associated with changes in use. Conclusions: Studies evaluating drug decriminalisation and legal regulation are concentrated in the USA and on cannabis legalisation. Despite the range of outcomes potentially impacted by drug law reform, extant research is narrowly focussed, with a particular emphasis on the prevalence of use. Metrics in drug law reform evaluations require improved alignment with relevant health and social outcomes.
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The scope of the review was limited to recreational legalization and did not consider other forms of policy changes such as medicinal legalization or decriminalization.
“Additionally, the scope of the review was limited to recreational legalization and did not consider other forms of policy changes such as medicinal legalization or decriminalization, as these have been summarized more comprehensively in prior reviews.112-114”
From The Impact of Recreational Cannabis Legalization on Cannabis Use and Associated Outcomes: A Systematic Review (2023) · cites this paper as [113]
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Development of a rational scale to assess the harm of drugs of potential misuse
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Farrelly, K. N., Wardell, J. D., Marsden, E., Scarfe, M. L., Najdzionek, P., Turna, J., & MacKillop, J. (2023) · Substance Abuse Research and Treatment · doi:10.1177/11782218231172054 · Cited by 148 · see citing works
“Criminalization Causes the Stigma”: Perspectives From People Who Use Drugs
Scher, B. D., Neufeld, S. D., Butler, A., Bonn, M., Zakimi, N., Farrell, J., & Greer, A. (2023) · Contemporary Drug Problems · doi:10.1177/00914509231179226 · Cited by 90 · see citing works
- Authors
- Scheim, A. I., Maghsoudi, N., Marshall, Z., Churchill, S., Ziegler, C., & Werb, D.
- Affiliations
- St. Michael's Hospital (CA)
- McGill University (CA)
- Western University (CA)
- Unity Health Toronto (CA)
- Corresponding author
- Werb, Dan
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2020-09
- Volume
- 10
- Issue
- 9
- Pages
- e035148
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC7507857
- OpenAlex
- W3087726603
- Cited by
- 63
- References
- 7
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 7 · 2023: 18 · 2022: 11 · 2021: 5 · 2020: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Open Society Foundations
- Ontario Ministry of Research, Innovation and Science
- National Institutes of Health (1dp2da040256-01)
- Canadian Institutes of Health Research (#SMN-139 150)
- National Institute on Drug Abuse (DP2-DA040256)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Sociology and Political Science › Criminal Law and Policy
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Keywords
- drug decriminalization, drug policy reform, cannabis legalization, drug use prevalence, substance use outcomes, health damage, social harm, drug availability, evaluation metrics, alcohol and tobacco use
- MeSH terms
- Cannabis, Pharmaceutical Preparations, Humans, Legislation, Drug, Outcome Assessment, Health Care, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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