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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Open accessAbstract
Background and aim: Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivity. Methods: Visceral sensitivity to colorectal distension (CRD) was assessed at intervals in healthy mice for up to 12 weeks, and in mice before and after administration of dexamethasone or non-absorbable antibiotics with or without supplementation with Lactobacillus paracasei (NCC2461). Tissue was obtained for measurement of myeloperoxidase activity (MPO), histology, microbiota analysis, and substance P (SP) immunolabelling. Results: Visceral hypersensitivity developed over time in healthy mice maintained without sterile precautions. This was accompanied by a small increase in MPO activity. Dexamethasone treatment normalised MPO and CRD responses. Antibiotic treatment perturbed gut flora, increased MPO and SP immunoreactivity in the colon, and produced visceral hypersensitivity. Administration of Lactobacillus paracasei in spent culture medium normalised visceral sensitivity and SP immunolabelling, but not intestinal microbiota counts. Conclusion: Perturbations in gut flora and in inflammatory cell activity alter sensory neurotransmitter content in the colon, and result in altered visceral perception. Changes in gut flora may be a basis for the variability of abdominal symptoms observed in functional gastrointestinal disorders and may be prevented by specific probiotic administration.
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In the citing paper
“The use of probiotics, particularly in animal models, also demonstrates that their secreted products or metabolites can modulate contractility of intestinal smooth muscle and visceral sensitivity.59–61”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [59]
In the citing paper
“In mice, perturbation of the microbiota by exposure to antibiotics resulted in increased visceromotor responses to colonic distension (182).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [182]
In the citing paper
“Interestingly, in this model, treatment of mice with Lactobacillus ameliorated inflammatory indexes in the gut wall and reduced the antibiotic-induced visceromotor response.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [182]
In the citing paper
“Moreover, several studies linking the gut microbiota with visceral sensitivity, have shown that increments in the Lactobacilli family (during probiotic treatment or during states of dysbiosis) are associated to visceral analgesic-like states.18,19,21,33”
From Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice (2015) · cites this paper as [18]
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Metadata
- Authors
- Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M.
- Affiliations
- McMaster University (CA)
- Nestlé (Switzerland) (CH)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-08-16
- Volume
- 55
- Issue
- 2
- Pages
- 182-190
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1856497
- OpenAlex
- W2029071453
- Cited by
- 448
- References
- 47
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 21 · 2021: 25 · 2020: 32 · 2019: 23 · 2018: 23 · 2017: 25 · 2016: 26 · 2015: 27 · 2014: 27 · 2013: 26 · 2012: 26
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Gut (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Canadian Association of Gastroenterology
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- visceral hypersensitivity, probiotics, Lactobacillus paracasei, antibiotic-induced dysbiosis, gut microbiota, colorectal distension, dexamethasone, myeloperoxidase, substance P, gut-brain axis, functional gastrointestinal disorders, abdominal pain, intestinal inflammation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Dexamethasone, Electromyography, Female, Hyperalgesia, Intestines, Mice, Inbred BALB C, Peroxidase, Physical Stimulation, Substance P, Abdominal Pain, Culture Media, Conditioned, Probiotics, Irritable Bowel Syndrome, Mice
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