Cited by 448Gastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods

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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

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Verdú, E F, Bercik, P, Verma-Gandhu, M, Huang, X-X, Blennerhassett, P, Jackson, W, Mao, Y, Wang, L, Rochat, F, Collins, S M·2006·Gut

DOI 10.1136/gut.2005.066100PMC PMC1856497

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Abstract

Background and aim: Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivity. Methods: Visceral sensitivity to colorectal distension (CRD) was assessed at intervals in healthy mice for up to 12 weeks, and in mice before and after administration of dexamethasone or non-absorbable antibiotics with or without supplementation with Lactobacillus paracasei (NCC2461). Tissue was obtained for measurement of myeloperoxidase activity (MPO), histology, microbiota analysis, and substance P (SP) immunolabelling. Results: Visceral hypersensitivity developed over time in healthy mice maintained without sterile precautions. This was accompanied by a small increase in MPO activity. Dexamethasone treatment normalised MPO and CRD responses. Antibiotic treatment perturbed gut flora, increased MPO and SP immunoreactivity in the colon, and produced visceral hypersensitivity. Administration of Lactobacillus paracasei in spent culture medium normalised visceral sensitivity and SP immunolabelling, but not intestinal microbiota counts. Conclusion: Perturbations in gut flora and in inflammatory cell activity alter sensory neurotransmitter content in the colon, and result in altered visceral perception. Changes in gut flora may be a basis for the variability of abdominal symptoms observed in functional gastrointestinal disorders and may be prevented by specific probiotic administration.

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Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780
Alteration of Intestinal Microflora Is Associated With Reduction in Abdominal Bloating and Pain in Patients With Irritable Bowel Syndrome
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653
Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial
Atkinson, W., Sheldon, T. A., Shaath, N., & Whorwell, P. J. (2004) · Gut · doi:10.1136/gut.2003.037697 · Cited by 534
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473

Show all 47 references

Research works printed but not linked: 9

2003, Rev Gastroenterol Disord, S12, 12
1998, Dev Immunol, 6, 13
1968, Lab Anim Care, 18, 1
2004, J Orofac Pain, 18, 62
2004, Gastroenterology, 126, A161
1968, Am J Med Sci, 255, 63
2003, Folia Morphol (Warsz), 62, 455
1999, Am J Physiol, 277, L831
10.1046/j.1365-2982.2003.00458.x · DOI

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Authors: Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M.
Affiliations: McMaster University (CA)
Nestlé (Switzerland) (CH)
Venue: Gut
Publisher: BMJ
Published: 2005-08-16
Volume: 55
Issue: 2
Pages: 182-190
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2005.066100
PMC: PMC1856497
OpenAlex: W2029071453
Cited by: 448
References: 47
Citations by year: 2026: 2 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 21 · 2021: 25 · 2020: 32 · 2019: 23 · 2018: 23 · 2017: 25 · 2016: 26 · 2015: 27 · 2014: 27 · 2013: 26 · 2012: 26
FWCI: 12.85
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
Locations: Gut (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Canadian Association of Gastroenterology
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: visceral hypersensitivity, probiotics, Lactobacillus paracasei, antibiotic-induced dysbiosis, gut microbiota, colorectal distension, dexamethasone, myeloperoxidase, substance P, gut-brain axis, functional gastrointestinal disorders, abdominal pain, intestinal inflammation
MeSH terms: Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Dexamethasone, Electromyography, Female, Hyperalgesia, Intestines, Mice, Inbred BALB C, Peroxidase, Physical Stimulation, Substance P, Abdominal Pain, Culture Media, Conditioned, Probiotics, Irritable Bowel Syndrome, Mice

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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

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