The effect of long-term or repeated use of antibiotics in children and adolescents on cognitive impairment in middle-aged and older person(s) adults: a cohort study
Open accessAbstract
Objectives We evaluated the effects of long-term/recurrent use of antibiotics in childhood on developing cognitive impairment in middle and old age from UK Biobank Database. Methods UK Biobank recruited participants aged 37–73 years. Cognitive impairment was ascertained by fluid intelligence questionnaire. Primary outcome was the occurrence of cognitive impairment in middle and old age. Multivariate logistic regression models were used to explore the relationship between long-term/recurrent use of antibiotics and cognitive impairment. Results Over 3.8–10.8 years’ follow-up, 4,781 of the 35,921 participants developed cognitive impairment. The odds of cognitive impairment in middle and old age among long-term/recurrent use of antibiotics in childhood were increased by 18% compared with their counterparts (adjusted odd ratio 1.18, 95% confidence interval 1.08–1.29, p < 0.01). The effect of long-term/recurrent use of antibiotics in childhood on cognitive impairment was homogeneous across different categories of various subgroup variables such as sex, age, APOE4, ethnic groups, income before tax, smoking status, alcohol status, BMI, hypertension and diabetes but the effect of long-term/recurrent use of antibiotics in childhood was modified by the educational qualification (p-value for interaction <0.05). Conclusion Long-term/recurrent use of antibiotics in childhood may increase the risk of cognitive impairment in middle and old age.
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The microbiota-gut-brain axis has multiple sites for off-target activity, which may lead to positive or negative neurocognitive effects downstream.
“Certainly, the MGB axis has multiple sites for off-target activity, which may lead to positive or negative neurocognitive effects downstream, emphasizing the importance of antibiotic stewardship (404–407).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [406]
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- Authors
- Liu, Z., Wei, S., Chen, X., Liu, L., Wei, Z., Liao, Z., Wu, J., Li, Z., Zhou, H., & Wang, D.
- Affiliations
- Guangdong Medical College (CN)
- Central People's Hospital of Zhanjiang (CN)
- Chenzhou First People's Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Corresponding author
- Zhou, Haihong
- Wang, Duolao
- ORCID
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-03-23
- Volume
- 14
- Pages
- 833365-833365
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC8984107
- OpenAlex
- W4220916912
- Cited by
- 10
- References
- 61
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSTM Online Archive (Liverpool School of Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Medical Research Council (MC_PC_17228)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- long-term antibiotic use, cognitive impairment, fluid intelligence, middle-aged and older adults, educational attainment, APOE ε4, UK Biobank
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