Cited by 448Gastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods

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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

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Verdú, E F, Bercik, P, Verma-Gandhu, M, Huang, X-X, Blennerhassett, P, Jackson, W, Mao, Y, Wang, L, Rochat, F, Collins, S M·2006·Gut

DOI 10.1136/gut.2005.066100PMC PMC1856497

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Abstract

Background and aim: Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivity. Methods: Visceral sensitivity to colorectal distension (CRD) was assessed at intervals in healthy mice for up to 12 weeks, and in mice before and after administration of dexamethasone or non-absorbable antibiotics with or without supplementation with Lactobacillus paracasei (NCC2461). Tissue was obtained for measurement of myeloperoxidase activity (MPO), histology, microbiota analysis, and substance P (SP) immunolabelling. Results: Visceral hypersensitivity developed over time in healthy mice maintained without sterile precautions. This was accompanied by a small increase in MPO activity. Dexamethasone treatment normalised MPO and CRD responses. Antibiotic treatment perturbed gut flora, increased MPO and SP immunoreactivity in the colon, and produced visceral hypersensitivity. Administration of Lactobacillus paracasei in spent culture medium normalised visceral sensitivity and SP immunolabelling, but not intestinal microbiota counts. Conclusion: Perturbations in gut flora and in inflammatory cell activity alter sensory neurotransmitter content in the colon, and result in altered visceral perception. Changes in gut flora may be a basis for the variability of abdominal symptoms observed in functional gastrointestinal disorders and may be prevented by specific probiotic administration.

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Authors: Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M.
Affiliations: McMaster University (CA)
Nestlé (Switzerland) (CH)
Venue: Gut
Publisher: BMJ
Published: 2005-08-16
Volume: 55
Issue: 2
Pages: 182-190
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2005.066100
PMC: PMC1856497
OpenAlex: W2029071453
Cited by: 448
References: 47
Citations by year: 2026: 2 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 21 · 2021: 25 · 2020: 32 · 2019: 23 · 2018: 23 · 2017: 25 · 2016: 26 · 2015: 27 · 2014: 27 · 2013: 26 · 2012: 26
FWCI: 12.85
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
Locations: Gut (publishedVersion, public-domain)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Canadian Association of Gastroenterology
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: visceral hypersensitivity, probiotics, Lactobacillus paracasei, antibiotic-induced dysbiosis, gut microbiota, colorectal distension, dexamethasone, myeloperoxidase, substance P, gut-brain axis, functional gastrointestinal disorders, abdominal pain, intestinal inflammation
MeSH terms: Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Dexamethasone, Electromyography, Female, Hyperalgesia, Intestines, Mice, Inbred BALB C, Peroxidase, Physical Stimulation, Substance P, Abdominal Pain, Culture Media, Conditioned, Probiotics, Irritable Bowel Syndrome, Mice

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Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

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