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Cited by 231Gut microbiota and healthDigestive system and related healthGastrointestinal motility and disorders

Colonic mucin synthesis is increased by sodium butyrate.

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Finnie, I A, Dwarakanath, A D, Taylor, B A, Rhodes, J M·1995·Gut
DOI 10.1136/gut.36.1.93PMC PMC1382360
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Abstract

The effects of sodium butyrate and sodium bromo-octanoate (an inhibitor of beta oxidation) on colonic mucus glycoprotein (mucin) synthesis have been assessed using tissue from colonic resection samples. Epithelial biopsy specimens were incubated for 16 hours in RPMI 1640 with glutamine, supplemented with 10% fetal calf serum and N-acetyl-[3H]-glucosamine ([3H]-Glc NAc), and differing concentrations of sodium butyrate. Incorporation of [3H] Glc NAc into mucin by normal epithelium at least 10 cm distant from colonic cancer was increased in the presence of sodium butyrate in a dose dependent manner, with maximum effect (476%) at a concentration of 0.1 mM (number of specimens = 24 from six patients, p < 0.001). The increase in response to butyrate was not seen when specimens were incubated in the presence of the beta oxidation inhibitor sodium bromo-octanoate 0.05 M. The striking increase in mucin synthesis that results when butyrate is added to standard nutrient medium suggests that this may be an important mechanism affecting the rate of mucin synthesis in vivo and may also explain the therapeutic effect of butyrate in colitis.

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  • SCFAs can enhance the mucosal barrier through the stimulation of mucus production, which is likely mediated through FFAR3.

    “SCFAs can enhance the mucosal barrier through the stimulation of mucus production (Barcelo et al., 2000;Finnie et al., 1995;Jung et al., 2015;Willemsen et al., 2003), which is likely mediated through FFAR3 (Said et al., 2017).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Finnie et al., 1995

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Authors
Finnie, I. A., Dwarakanath, A. D., Taylor, B. A., & Rhodes, J. M.
Affiliations
University of Liverpool (GB)
ORCID
Rhodes, J M
Venue
Gut
Publisher
BMJ
Published
1995-01
Volume
36
Issue
1
Pages
93-99
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.36.1.93
PMC
PMC1382360
OpenAlex
W2098209207
Cited by
231
References
0
Citations by year
2026: 7 · 2025: 6 · 2024: 11 · 2023: 19 · 2022: 12 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
1.74
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
sodium butyrate, mucus glycoproteins, beta-oxidation inhibition, colonic epithelium, short-chain fatty acids
MeSH terms
Adult, Aged, Butyrates, Caprylates, Chromatography, Agarose, Colitis, Ulcerative, Colon, Dose-Response Relationship, Drug, Female, Humans, Kinetics, Male, Mucins, Butyric Acid, Culture Techniques

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