Cited by 115Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Effect of butyrate and fermentation products on epithelial integrity in a mucus-secreting human colon cell line

Open access
Nielsen, Ditte Søvsø Gundelund, Jensen, Bent Borg, Theil, Peter Kappel, Nielsen, Tina Skau, Knudsen, Knud Erik Bach, Purup, Stig·2018·Journal of Functional Foods

Integrity signals

Registry

Crossref · 10.1016/j.jff.2017.10.023

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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Recomputing p-values needs the paper’s full text.

Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Butyrate and valerate promote intestinal barrier function, which prevents the translocation of pathogens from the intestine into the bloodstream.

    “Butyrate and valerate promote intestinal barrier function, which prevents the translocation of pathogens from the intestine into the bloodstream [45–48].”
  • At higher concentrations (50-100 mM), sodium butyrate showed no beneficial effects on MUC2 expression patterns, likely due to the induction of apoptosis at higher doses.

    “However, at higher concentrations (50–100 mM), it showed no beneficial effects on MUC2 expression patterns,79 likely due to the induction of apoptosis at higher doses.”
  • Sodium butyrate at a concentration ranging between 1 and 10 mM significantly improved epithelial barrier function in E12 human colon cells by increasing the levels of mucin 2.

    “It was shown that sodium butyrate at a concentration ranging between 1 and 10 mM significantly improved epithelial barrier function in E12 human colon cells by increasing the levels of mucin 2 (MUC2).79”

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Authors
Nielsen, D. S. G., Jensen, B. B., Theil, P. K., Nielsen, T. S., Knudsen, K. E. B., & Purup, S.
Affiliations
Aarhus University (DK)
Corresponding author
Nielsen, Ditte Søvsø Gundelund
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2018-01
Volume
40
Pages
9-17
ISSN
1756-4646 (ISSN-L)
OpenAlex
W2781217172
Cited by
115
References
44
Citations by year
2026: 14 · 2025: 15 · 2024: 26 · 2023: 17 · 2022: 12 · 2021: 16 · 2020: 8 · 2019: 6 · 2018: 1
FWCI
1.68
Type
journal article
Language
en
Open access
Locations
  • Journal of Functional Foods (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Danish Council for Strategic Research (10-093526)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
butyrate, arabinoxylan, Butyrivibrio fibrisolvens, Eubacterium rectale, mucus secretion, synbiotics, dietary fiber fermentation, probiotics, oxidative stress, apoptosis, colonic epithelium

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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