Effect of butyrate and fermentation products on epithelial integrity in a mucus-secreting human colon cell line
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Butyrate and valerate promote intestinal barrier function, which prevents the translocation of pathogens from the intestine into the bloodstream.
“Butyrate and valerate promote intestinal barrier function, which prevents the translocation of pathogens from the intestine into the bloodstream [45–48].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [47]
At higher concentrations (50-100 mM), sodium butyrate showed no beneficial effects on MUC2 expression patterns, likely due to the induction of apoptosis at higher doses.
“However, at higher concentrations (50–100 mM), it showed no beneficial effects on MUC2 expression patterns,79 likely due to the induction of apoptosis at higher doses.”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [79]
Sodium butyrate at a concentration ranging between 1 and 10 mM significantly improved epithelial barrier function in E12 human colon cells by increasing the levels of mucin 2.
“It was shown that sodium butyrate at a concentration ranging between 1 and 10 mM significantly improved epithelial barrier function in E12 human colon cells by increasing the levels of mucin 2 (MUC2).79”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [79]
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- Authors
- Nielsen, D. S. G., Jensen, B. B., Theil, P. K., Nielsen, T. S., Knudsen, K. E. B., & Purup, S.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Nielsen, Ditte Søvsø Gundelund
- ORCID
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 40
- Pages
- 9-17
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2781217172
- Cited by
- 115
- References
- 44
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 26 · 2023: 17 · 2022: 12 · 2021: 16 · 2020: 8 · 2019: 6 · 2018: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Danish Council for Strategic Research (10-093526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- butyrate, arabinoxylan, Butyrivibrio fibrisolvens, Eubacterium rectale, mucus secretion, synbiotics, dietary fiber fermentation, probiotics, oxidative stress, apoptosis, colonic epithelium
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