Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
Open accessAbstract
BACKGROUND: Glucagon-like peptide-1(7-36)amide (GLP-1) is a gut hormone released postprandially. Synthetic GLP-1 strongly inhibits gastric emptying in healthy subjects and in patients with diabetes mellitus. AIMS: To investigate the effects of GLP-1 on antro-pyloro-duodenal motility in humans. METHODS: Eleven healthy male volunteers were studied on two separate days. On the interdigestive study day, a basal period was followed by a 60 minute period of saline infusion and two further 60 minute periods of intravenous infusion of GLP-1 0.4 and 1.2 pmol/kg/min to achieve postprandial and supraphysiological plasma levels, respectively. On the postprandial study day, the same infusions were coadministered with intraduodenal lipid perfusion at 2.5 ml/min (2.5 kcal/min) followed by another 60 minutes of recording after cessation of GLP-1. Antro-pyloro-duodenal motility was measured by perfusion manometry. RESULTS: GLP-1 significantly inhibited the number and amplitudes of antral and duodenal contractions in the interdigestive state and after administration of duodenal lipid. It abolished interdigestive antral wave propagation. In the interdigestive state, GLP-1 dose dependently increased pyloric tone and significantly stimulated isolated pyloric pressure waves (IPPW). Pyloric tone increased with duodenal lipid, and this was further enhanced by GLP-1. GLP-1 transiently restored the initial IPPW response to duodenal lipid which had declined with lipid perfusion. Plasma levels of pancreatic polypeptide were dose dependently diminished by GLP-1 with and without duodenal lipid. CONCLUSIONS: GLP-1 inhibited antro-duodenal contractility and stimulated the tonic and phasic motility of the pylorus. These effects probably mediate delayed gastric emptying. Inhibition of efferent vagal activity may be an important mechanism. As postprandial plasma levels of GLP-1 are sufficient to appreciably affect motility, we believe that endogenous GLP-1 is a physiological regulator of motor activity in the antro-pyloro-duodenal region.
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In healthy subjects, this GLP-1 dose inhibited antro-duodenal contractility, increased pyloric tone, and increased fasting gastric volumes.
“In healthy subjects, this dose inhibited antro-duodenal contractility, increased pyloric tone, and also increased fasting gastric volumes (1, 40).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [40]
The Abstract and Discussion (page not available) report inhibited antroduodenal contractions and increased pyloric tone in healthy volunteers. The paper did not measure fasting gastric volume; its Discussion mentions only preliminary evidence from another study of proximal-stomach relaxation at the same doses, which does not establish the claimed increase in fasting volume. (LLM, conf=0.88)
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- Authors
- Schirra, J., Houck, P., Wank, U., Arnold, R., Göke, B., & Katschinski, M.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Schirra, J
- ORCID
- Schirra, J
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2000-05-01
- Volume
- 46
- Issue
- 5
- Pages
- 622-631
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727942
- OpenAlex
- W2097325055
- Cited by
- 145
- References
- 58
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucagon-like peptide-1(7-36)amide, antral contractions, pancreatic polypeptide, gastric emptying, vagal efferent activity, gastrointestinal hormones
- MeSH terms
- Adult, Duodenum, Gastric Emptying, Gastrointestinal Motility, Glucagon, Humans, Lipids, Male, Manometry, Peptide Fragments, Pressure, Protein Precursors, Pyloric Antrum, Time Factors, Postprandial Period, Glucagon-Like Peptide 1
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