Taste receptors of the gut: emerging roles in health and disease

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Taste and its receptors in human physiology: A comprehensive look

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Macronutrient Sensing in the Oral Cavity and Gastrointestinal Tract: Alimentary Tastes

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The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates

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Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson’s Disease

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Nutrient Sensing via Gut in Drosophila melanogaster

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Transcellular Barriers to Glucose Delivery in the Body

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Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction

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The druggability of bitter taste receptors for the treatment of neurodegenerative disorders

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A Comparative Study on the Effects of Different Sources of Carboxymethyl Poria Polysaccharides on the Repair of DSS-Induced Colitis in Mice

Tan, Z., Zhang, Q., Zhao, R., Huang, T., Tian, Y., & Lin, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109034 · Cited by 29

Translating physiological signals to changes in feeding behaviour in mammals and the future effects of global climate change

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Acute effects of monosodium glutamate addition to whey protein on appetite, food intake, blood glucose, insulin and gut hormones in healthy young men

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Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia

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Synthesis: foraging decisions link plants, herbivores and human beings

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Taste receptor function

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Taste and the regulation of food intake: it’s not just about flavor

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Nutrient-Sensing Biology in Mammals and Birds

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Luminal short‐chain fatty acids and 5‐HT acutely activate myenteric neurons in the mouse proximal colon

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Taste receptors in the gastrointestinal system

Gabriel, A. M. S. (2015) · Flavour · doi:10.1186/2044-7248-4-14 · Cited by 25

Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships

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Biomimetic Sensors for the Senses: Towards Better Understanding of Taste and Odor Sensation

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Selective integration of diverse taste inputs within a single taste modality

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The gut odorant receptor and taste receptor make sense of dietary components: A focus on gut hormone secretion

Wang, Y., Geng, R., Zhao, Y., Fang, J., Li, M., Kang, S., Huang, K., & Tong, T. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2177610 · Cited by 26

Citrus aurantium flavonoid extract improves concentrate efficiency, animal behavior, and reduces rumen inflammation of Holstein bulls fed high-concentrate diets

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Update on Dietary Management of Childhood Functional Abdominal Pain Disorders

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Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer

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Comparison of the effects of chlorogenic acid isomers and their compounds on alleviating oxidative stress injury in broilers

Song, D., Zhang, S., Chen, A., Song, Z., & Shi, S. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103649 · Cited by 23

Gastrointestinally Digested Protein from the Insect Alphitobius diaperinus Stimulates a Different Intestinal Secretome than Beef or Almond, Producing a Differential Response in Food Intake in Rats

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Impact of feeding diets with enhanced vegetable protein content and presence of umami taste-stimulating additive on gastrointestinal amino acid sensing and feed intake regulation in rainbow trout

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Supplementation of oligofructose, but not sucralose, decreases high‐fat diet induced body weight gain in mice independent of gustducin‐mediated gut hormone release

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Obesity Impairs Oligopeptide/Amino Acid‐Induced Ghrelin Release and Smooth Muscle Contractions in the Human Proximal Stomach

Vancleef, L., Thijs, T., Baert, F., Ceulemans, L. J., Canovai, E., Wang, Q., Steensels, S., Segers, A., Farré, R., Pirenne, J., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700804 · Cited by 20

Rectal Insulin Instillation Inhibits Inflammation and Tumor Development in Chemically Induced Colitis

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Effects of dietary protein sources on growth performance and feed intake regulation of grass carp (Ctenopharyngodon idellus)

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Oral and intestinal sweet and fat tasting: impact of receptor polymorphisms and dietary modulation for metabolic disease

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Structural equation modeling of associations among taste‐related risk factors, taste functioning, and adiposity

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Fat taste signal transduction and its possible negative modulator components

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Higher TNF-α, IGF-1, and leptin levels are found in tasters than non-tasters

Wang, R. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00125 · Cited by 20

Low calorie sweeteners: Science and controversy

Mattes, R. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.005 · Cited by 19

MONOSODIUM GLUTAMATE SAFETY, NEUROTOXICITY AND SOME RECENT STUDIES

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Effects of food formulation on bioavailability of phytosterols: phytosterol structures, delivery carriers, and food matrices

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Interactions of Gut Endocrine Cells with Epithelium and Neurons

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Taste receptors in the gut tune the release of peptides in response to nutrients

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Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice

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Review on the Regional Effects of Gastrointestinal Luminal Stimulation on Appetite and Energy Intake: (Pre)clinical Observations

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Gastrointestinal defense mechanisms

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Gastrointestinal hormone-mediated beneficial bioactivities of bitter polyphenols

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Could hop-derived bitter compounds improve glucose homeostasis by stimulating the secretion of GLP-1?

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Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice

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Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs

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Gastrointestinal Symptoms in Morbid Obesity

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Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity

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Encapsulation for Masking Off-Flavor and Off-Tasting in Food Production

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Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects

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T1R1 expression in obscure puffer (Takifugu fasciatus) is associated with effect of dietary soybean antigenic protein on intestinal health

Yao, J., Kong, C., Hua, X., Yang, J.-F., Liu, T., Wang, G., Shui, C., Feng, Y., & Shi, Y. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.11.010 · Cited by 16

Sugar Addiction: Neural Mechanisms and Health Implications

Qin, D., Qi, J., Shi, F., Guo, Z., & Li, H. (2025) · Brain and Behavior · doi:10.1002/brb3.70338 · Cited by 22

A multifaceted review of monosodium glutamate effects on human health and its natural remedies

Yang, L., Gao, Y., Gong, J., Peng, L., El-Seedi, H. R., Farag, M. A., Zhao, Y., & Xiao, J. (2023) · Food Materials Research · doi:10.48130/fmr-2023-0016 · Cited by 15

Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity

Caremoli, F., Huynh, J., Lagishetty, V., Markovic, D., Braun, J. G., Dong, T. S., Jacobs, J. P., & Sternini, C. (2023) · Nutrients · doi:10.3390/nu15194145 · Cited by 15

The Effects of Artificial Sweeteners on Intestinal Nutrient-Sensing Receptors: Dr. Jekyll or Mr. Hyde?

Posta, E., Fekete, I., Gyarmati, E., Stündl, L., Zöld, É., & Barta, Z. (2023) · Life · doi:10.3390/life14010010 · Cited by 31

The role of nutrient sensing in the metabolic changes after gastric bypass surgery

Steensels, S., Lannoo, M., Avau, B., Laermans, J., Vancleef, L., Farré, R., Verbeke, K., & Depoortere, I. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0541 · Cited by 15

Effect of soybean antigenic protein on feed palatability of fishmeal replaced diets for obscure puffer (Takifugu fasciatus) and the alternation of diet preference by domestication

Jingting, Y., Danting, G., Chun, K., Ju, M., & Xueming, H. (2020) · Aquaculture Reports · doi:10.1016/j.aqrep.2020.100332 · Cited by 15

Nutrient‐sensing components of the mouse stomach and the gastric ghrelin cell

Nunez‐Salces, M., Li, H., Feinle‐Bisset, C., Young, R. L., & Page, A. J. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13944 · Cited by 15

Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice

Cao, W., Fang, L., Li, R. W., Chin, Y., Wang, Y., Xue, C., & Tang, Q. (2021) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.07.018 · Cited by 16

Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease

Turner, A., Chijoff, E., Veysey, M. J., Keely, S., Scarlett, C. J., Lucock, M. D., & Beckett, E. (2019) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2019.100106 · Cited by 16

The taste for health: the role of taste receptors and their ligands in the complex food/health relationship

Morini, G. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1396393 · Cited by 14

Evolution of dietary preferences and the innate urge to heal: Drug discovery lessons from Ayurveda

Shrungeswara, A. H., & Unnikrishnan, M. K. (2018) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2017.08.003 · Cited by 14

Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

Angotzi, A. R., Leal, E., Puchol, S., Cerdá‐Reverter, J. M., & Morais, S. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.08.010 · Cited by 13

Beyond Sensory Properties: Molecular Interactions of Antioxidant Flavour-Active Polyphenols Across the Food-Oral-Gut Axis

Ferreira, I. M., Martins, S. A., Gonçalves, L., de Jesus, M., Brandão, E., & Soares, S. (2026) · Antioxidants · doi:10.3390/antiox15030397 · Cited by 13

Supplementing Citrus aurantium Flavonoid Extract in High-Fat Finishing Diets Improves Animal Behavior and Rumen Health and Modifies Rumen and Duodenum Epithelium Gene Expression in Holstein Bulls

Paniagua, M., Crespo, J., Arı́s, A., & Devant, M. (2022) · Animals · doi:10.3390/ani12151972 · Cited by 13

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Zhang, T., Zhang, B., Ma, X., Zhang, J., Wei, Y., Wang, F., & Tang, X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1109510 · Cited by 15

Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition of Metastatic Phenotype

Skapinker, E., Aldbai, R., Aucoin, E. B., Clarke, E., Clark, M., Ghokasian, D., Kombargi, H. L., Abraham, M. J., Li, Y., Bunsick, D. A., et al. (2024) · Nutrients · doi:10.3390/nu16121840 · Cited by 13

A role for airway taste receptor modulation in the treatment of upper respiratory infections

Douglas, J. E., Saunders, C. J., Reed, D. R., & Cohen, N. A. (2016) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2016.1135742 · Cited by 13

Is gastrointestinal motility related to alkaloids of Charred Semen Arecae?

Zhang, F., Yang, P., He, Q., Dong, X., & Zhang, S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112825 · Cited by 13

Evidence of gastrointestinal sensing and gut-brain communication in rainbow trout (Oncorhynchus mykiss) in response to the aqueous extract of fishmeal and its free amino acid fraction

Calo, J., Soengas, J. L., Pastor, J. J., Blanco, A. M., & Morais, S. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739264 · Cited by 13

Functional roles of low calorie sweeteners on gut function

Meyer‐Gerspach, A. C., Wölnerhanssen, B. K., & Beglinger, C. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.045 · Cited by 13

Gut Taste Stimulants Alter Brain Activity in Areas Related to Working Memory: a Pilot Study

Meyer‐Gerspach, A. C., Suenderhauf, C., Bereiter, L., Zanchi, D., Beglinger, C., Borgwardt, S., & Wölnerhanssen, B. K. (2016) · Neurosignals · doi:10.1159/000442612 · Cited by 13

Dual real-time in vivo monitoring system of the brain-gut axis

Nishimura, Y., Fukuda, Y., Okonogi, T., Yoshikawa, S., Karasuyama, H., Osakabe, N., Ikegaya, Y., Sasaki, T., & Adachi, T. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.090 · Cited by 13

α-Transducin and α-gustducin immunoreactive cells in the stomach of common sole (Solea solea) fed with mussel meal

Mazzoni, M., Bonaldo, A., Gatta, P. P., Vallorani, C., Latorre, R., Canova, M., & Clavenzani, P. (2015) · Fish Physiology and Biochemistry · doi:10.1007/s10695-015-0031-3 · Cited by 12

Effects of Intraduodenal Infusions of L-phenylalanine and L-glutamine on Antropyloroduodenal Motility and Plasma Cholecystokinin in Healthy Men

Steinert, R. E., Landrock, M. F., Horowitz, M., & Feinle‐Bisset, C. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14143 · Cited by 12

Traditional Chinese Bitter Flavor theory: Is there any relation with taste type II receptors?

Zhang, Y.-X., Wang, X., Wang, S.-F., Zhang, Y., & Qiao, Y. (2016) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2016.04.011 · Cited by 12

Coffee and tea choices and intake patterns in 20-to-40 year old adults

Mikołajczyk-Stecyna, J., Malinowska, A. M., Młodzik-Czyżewska, M. A., & Chmurzyńska, A. (2020) · Food Quality and Preference · doi:10.1016/j.foodqual.2020.104115 · Cited by 12

Effects of gastrointestinal delivery of non-caloric tastants on energy intake: a systematic review and meta-analysis

Klaassen, T., Keszthelyi, D., Troost, F. J., Bast, A., & Masclee, A. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02485-4 · Cited by 12

Quercetin Enhances GLP‐1 Secretion via TAS2R38‐Mediated PLC Signaling in Enteroendocrine L‐Cells

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Intestinal alteration of α-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission

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Published Online First:

Depoortere, I., Depoortere, P. I., & Month, P. I. D. (2013)

Correspondence to

Depoortere, I., & Depoortere, P. I. (2013)

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