The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Taste receptors of the gut: emerging roles in health and disease
Abstract
Recent progress in unravelling the nutrient-sensing mechanisms in the taste buds of the tongue has triggered studies on the existence and role of chemosensory cells in the gut. Indeed, the gastrointestinal tract is the key interface between food and the human body and can sense basic tastes in much the same way as the tongue, through the use of similar G-protein-coupled taste receptors. These receptors 'taste' the luminal content and transmit signals that regulate nutrient transporter expression and nutrient uptake, and also the release of gut hormones and neurotransmitters involved in the regulation of energy and glucose homeostasis. Hence, they play a prominent role in the communication between the lumen, epithelium, smooth muscle cells, afferent nerve fibres and the brain to trigger adaptive responses that affect gastrointestinal function, food intake and glucose metabolism. This review summarises how sensing of nutrients by taste receptors along the gut plays a key role in the process of digestion, and how disturbances or adaptations of these chemosensory signalling pathways may contribute to the induction or resolution of a number of pathological conditions related to diabetes, obesity, or diet-induced symptom generation in irritable bowel syndrome. Targeting these receptors may represent a promising novel route for the treatment of a number of these diseases.
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“The gastrointestinal tract is the key interface between food and the human body and can sense basic tastes in much the same way as the tongue, through the use of similar G-protein-coupled taste receptors (60).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [60]
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2 retracted
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RetractedGeraedts, M. C. P., & Munger, S. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0372-13.2013 · Cited by 15
RetractedGhrelin is a growth-hormone-releasing acylated peptide from stomach
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Mammalian sweet taste receptors
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The receptors and cells for mammalian taste
Chandrashekar, J. V., Hoon, M. A., Ryba, N. J. P., & Zuker, C. S. (2006) · Nature · doi:10.1038/nature05401 · Cited by 1,632
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
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Cited by
Sorted by citations
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189
“The gastrointestinal tract is the key interface between food and the human body and can sense basic tastes in much the same way as the tongue, through the use of similar G-protein-coupled taste receptors (60).”
BackgroundSteinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases
Lee, D. Y., Albenberg, L. G., Compher, C. W., Baldassano, R. N., Piccoli, D. A., Lewis, J. D., & Wu, G. D. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.007 · Cited by 388
Therapeutic potential of ectopic olfactory and taste receptors
Lee, S., Depoortere, I., & Hatt, H. H. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0002-3 · Cited by 282
Self-citation
Metadata
- Authors
- Depoortere, I.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Depoortere, Inge
- ORCID
- Depoortere, Inge
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-10-16
- Volume
- 63
- Issue
- 1
- Pages
- 179-190
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2167380176
- Cited by
- 315
- References
- 142
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 20 · 2023: 19 · 2022: 13 · 2021: 38 · 2020: 26 · 2019: 25 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 28 · 2014: 14 · 2013: 2
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- G protein-coupled receptors, chemosensory cells, nutrient sensing, nutrient uptake, gastrointestinal hormones, neurotransmitters, energy homeostasis, glucose homeostasis, gastrointestinal function, dietary intake, digestion, diabetes mellitus, obesity, irritable bowel syndrome, receptor-targeted therapy
- MeSH terms
- Chemoreceptor Cells, Diabetes Mellitus, Type 2, Gastric Mucosa, Humans, Intestinal Mucosa, Obesity, Taste Buds, Gastric Bypass, Biomarkers, Irritable Bowel Syndrome, Receptors, G-Protein-Coupled
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