The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
The role of mast cells in functional GI disorders
Open accessAbstract
Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16–26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity. These findings come to challenge the traditional view of FGIDs as pure functional disorders, and relate the origin to a tangible organic substrate. The mucosal inflammatory infiltrate is dominated by mast cells, eosinophils and intraepithelial lymphocytes in the intestine of FGIDs. It is well established that mast cell activation can generate epithelial and neuro-muscular dysfunction and promote visceral hypersensitivity and altered motility patterns in FGIDs, postoperative ileus, food allergy and inflammatory bowel disease. This review will discuss the role of mucosal mast cells in the gastrointestinal tract with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Mast cell-orchestrated immunity to pathogens
Abraham, S. N., & John, A. L. S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2782 · Cited by 959
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783
Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
Galli, S. J., Grimbaldeston, M. A., & Tsai, M. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2327 · Cited by 757
Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655
da Silva, E. Z. M., Jamur, M. C., & Oliver, C. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414545334 · Cited by 645
Bischoff, S. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2018 · Cited by 631
Cited by
Sorted by citations
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., Agrawal, A., Aziz, I., Farmer, A. D., Eugenicos, M. P., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324598 · Cited by 592
Moeser, A. J., Pohl, C. S., & Rajput, M. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.06.003 · Cited by 452
“…et al., 2013; Choi et al., 2013; Galli et al., 2008) and enteric neurons (Barbara et al., 2004; Kirsch and Riddell, 2006; Kobayashi et al., 1999; Wouters et al., 2016), mast cells might be major players regulating immune and ENS dysfunction observed in early weaned pigs, but the precise role of…”
BackgroundInfluentialRole of microbiota-derived short-chain fatty acids in cancer development and prevention
Mirzaei, R., Afaghi, A., Babakhani, S., Sohrabi, M., Hosseini‐Fard, S. R., Babolhavaeji, K., Akbari, S. K. A., Yousefimashouf, R., & Karampoor, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111619 · Cited by 416
Park, E., Han, J.-S., Park, E.-J., Seong, E., Lee, G., Kim, D., Son, H., Han, H., & Lee, B. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.01.008 · Cited by 305
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243
Metadata
- Authors
- Wouters, M. M., Vicario, M., & Santos, J.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Neuro-immuno-gastroenterology Laboratory, Digestive Diseases Research Unit. Vall d'Hebron Institut de Recerca, Department of Gastroenterology, Hospital Universitari Vall d'Hebron & Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
- Universitat Autònoma de Barcelona (ES)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2015-07-20
- Volume
- 65
- Issue
- 1
- Pages
- 155-168
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W1897161389
- Cited by
- 308
- References
- 144
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 23 · 2023: 26 · 2022: 47 · 2021: 38 · 2020: 33 · 2019: 29 · 2018: 31 · 2017: 26 · 2016: 23 · 2015: 2
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek (1248513 N)
- Ministerio de Economía y Competitividad (CP10/00502 &, CP10/00502, PI14/, PI11/00716 &, PI11/00716, PI14/00944, PI13/00935)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CB06/04/0021)
- Instituto de Salud Carlos III (PI13/00935, CB06/04/0021, PI11/, PI14/)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- mast cells, functional gastrointestinal disorders, irritable bowel syndrome, functional dyspepsia, visceral hypersensitivity, intestinal motility, mucosal inflammation, epithelial barrier function, eosinophils, intraepithelial lymphocytes, gut-brain axis, postoperative ileus, food allergy, inflammatory bowel disease
- MeSH terms
- Dyspepsia, Gastrointestinal Motility, Humans, Hypersensitivity, Intestinal Mucosa, Mast Cells, Phenotype, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
