Cited by 308Gastrointestinal motility and disordersMast cells and histamineInflammatory Bowel Disease

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The role of mast cells in functional GI disorders

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Wouters, Mira M, Vicario, Maria, Santos, Javier·2016·Gut

DOI 10.1136/gutjnl-2015-309151

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Abstract

Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16–26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity. These findings come to challenge the traditional view of FGIDs as pure functional disorders, and relate the origin to a tangible organic substrate. The mucosal inflammatory infiltrate is dominated by mast cells, eosinophils and intraepithelial lymphocytes in the intestine of FGIDs. It is well established that mast cell activation can generate epithelial and neuro-muscular dysfunction and promote visceral hypersensitivity and altered motility patterns in FGIDs, postoperative ileus, food allergy and inflammatory bowel disease. This review will discuss the role of mucosal mast cells in the gastrointestinal tract with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.

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Authors: Wouters, M. M., Vicario, M., & Santos, J.
Affiliations: Universitair Ziekenhuis Leuven (BE)
Neuro-immuno-gastroenterology Laboratory, Digestive Diseases Research Unit. Vall d'Hebron Institut de Recerca, Department of Gastroenterology, Hospital Universitari Vall d'Hebron & Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
Universitat Autònoma de Barcelona (ES)
ORCID: Wouters, Mira M
Santos, Javier
Venue: Gut
Publisher: BMJ
Published: 2015-07-20
Volume: 65
Issue: 1
Pages: 155-168
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2015-309151
OpenAlex: W1897161389
Cited by: 308
References: 144
Citations by year: 2026: 15 · 2025: 15 · 2024: 23 · 2023: 26 · 2022: 47 · 2021: 38 · 2020: 33 · 2019: 29 · 2018: 31 · 2017: 26 · 2016: 23 · 2015: 2
FWCI: 4.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
Funders: Fonds Wetenschappelijk Onderzoek (1248513 N)
Ministerio de Economía y Competitividad (CP10/00502 &amp, CP10/00502, PI14/, PI11/00716 &amp, PI11/00716, PI14/00944, PI13/00935)
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CB06/04/0021)
Instituto de Salud Carlos III (PI13/00935, CB06/04/0021, PI11/, PI14/)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: mast cells, functional gastrointestinal disorders, irritable bowel syndrome, functional dyspepsia, visceral hypersensitivity, intestinal motility, mucosal inflammation, epithelial barrier function, eosinophils, intraepithelial lymphocytes, gut-brain axis, postoperative ileus, food allergy, inflammatory bowel disease
MeSH terms: Dyspepsia, Gastrointestinal Motility, Humans, Hypersensitivity, Intestinal Mucosa, Mast Cells, Phenotype, Irritable Bowel Syndrome

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The role of mast cells in functional GI disorders

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