Mucosal microbiome dysbiosis in gastric carcinogenesis
Open accessAbstract
Objectives: We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. Design: We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi’an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China. Results: We observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q<0.05). Microbial network analysis showed increasing correlation strengths among them with disease progression (p<0.001). Five GC-enriched bacterial taxa whose species identifications correspond to Peptostreptococcus stomatis , Streptococcus anginosus , Parvimonas micra , Slackia exigua and Dialister pneumosintes had significant centralities in the GC ecological network (p<0.05) and classified GC from SG with an area under the receiver-operating curve (AUC) of 0.82. Moreover, stronger interactions among gastric microbes were observed in Helicobacter pylori -negative samples compared with H. pylori -positive samples in SG and IM. The fold changes of selected bacteria, and strengths of their interactions were successfully validated in the Inner Mongolian cohort, in which the five bacterial markers distinguished GC from SG with an AUC of 0.81. Conclusions: In addition to microbial compositional changes, we identified differences in bacterial interactions across stages of gastric carcinogenesis. The significant enrichments and network centralities suggest potentially important roles of P. stomatis , D. pneumosintes , S. exigua , P. micra and S. anginosus in GC progression.
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Through the induction of different metabolic pathways, such bacteria could have a role in gastric cancer (GC) progression.
“Through the induction of different metabolic pathways, such bacteria could have a role in gastric cancer (GC) progression[61].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [61]
High gastric pH values can give rise to a different bacterial balance characterized by a significant increase in oral bacteria, such as Peptostreptococcus stomatis, Streptococcus anginosus, Parvimonas micra, Slackia exigua and Dialister pneumosintes.
“Moreover, high gastric pH values can give rise to a different bacterial balance characterized by a significant increase in oral bacteria, such as Pepto-streptococcus stomatis, Streptococcus anginosus, Parvimonas micra, Slackia exigua and Dialister pneumosintes.”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [61]
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- Authors
- Coker, O. O., Dai, Z., Nie, Y., Zhao, G., Cao, L., Nakatsu, G., Wu, W. K., Wong, S. H., Chen, Z., Sung, J. J. Y., & Yu, J.
- Affiliations
- Chinese University of Hong Kong (HK)
- Xijing Hospital (CN)
- Inner Mongolia People's Hospital (CN)
- Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
- Corresponding author
- Yu, Jun
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2017-08-01
- Volume
- 67
- Issue
- 6
- Pages
- 1024-1032
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC5969346
- OpenAlex
- W2739778494
- Cited by
- 695
- References
- 52
- Citations by year
- 2026: 78 · 2025: 87 · 2024: 100 · 2023: 94 · 2022: 83 · 2021: 109 · 2020: 71 · 2019: 43 · 2018: 24 · 2017: 4
- FWCI
- 39.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gastric carcinogenesis, gastric microbiota, dysbiosis, gastric cancer, atrophic gastritis, intestinal metaplasia, superficial gastritis, Helicobacter pylori, bacterial interaction networks, Peptostreptococcus stomatis, Streptococcus anginosus, Parvimonas micra, Slackia exigua, Dialister pneumosintes, bacterial biomarkers, disease progression
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Transformation, Neoplastic, China, Female, Gastric Mucosa, Humans, Male, Middle Aged, RNA, Ribosomal, 16S, Stomach, Stomach Neoplasms, Area Under Curve, Young Adult, Carcinogenesis, Microbiota, Dysbiosis
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