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The cell biology of bone metabolism
Open accessAbstract
Contrary to the commonly held misconception, bone is a relatively dynamic organ that undergoes significant turnover as compared to other organs in the body. This review details how complex intercellular signalling, between the osteoprogenitor cells and mature osteoblasts, osteocytes and osteoclasts, regulates and balances activities of bone cells during remodelling and growth. Both systemic, as well as local autocrine and paracrine factors are discussed. A number of recent important advances in cell biology of bone have led to a new paradigm in understanding of the subject. In this regard, the interaction between the immune system and bone cells is of particular interest, leading to the emergence of a new discipline termed osteoimmunology. The role of lymphocytes and a number of key cytokines in the regulation of osteoclastogenesis and osteoblast function is critically examined. The intracellular signalling regulating key cellular pathways involved in cell differentiation and activity are outlined. The emerging evidence of osteocytes as mechanosensors as well as regulators of mineralisation is discussed.
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“Bone exerts important functions in the body, such as locomotion, support and protection of soft tissues, calcium and phosphate storage, and harboring of bone marrow [3, 4].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [4]
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Metadata
- Authors
- Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S.
- Affiliations
- Newcastle University (GB)
- Leeds General Infirmary (GB)
- James Cook University Hospital (GB)
- Corresponding author
- Datta, H K
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2008-04-25
- Volume
- 61
- Issue
- 5
- Pages
- 577-587
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2031883266
- Cited by
- 614
- References
- 170
- Citations by year
- 2026: 13 · 2025: 42 · 2024: 61 · 2023: 45 · 2022: 67 · 2021: 53 · 2020: 38 · 2019: 37 · 2018: 35 · 2017: 21 · 2016: 21 · 2015: 14 · 2014: 24 · 2013: 36 · 2012: 22
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- bone metabolism, bone turnover, osteoblasts, osteocytes, osteoclasts, osteoprogenitor cells, bone remodeling, bone growth, intercellular communication, osteoimmunology, lymphocytes, cytokines, osteoclastogenesis, osteogenic differentiation, intracellular signaling, mechanosensing, bone mineralization
- MeSH terms
- Bone and Bones, Cell Differentiation, Energy Metabolism, Humans, Osteoblasts, Osteoclasts, Osteocytes, Signal Transduction, Bone Remodeling
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