The cell biology of bone metabolism

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224

Novel Regulators of Bone Formation: Molecular Clones and Activities

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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608

Functional interaction of β-catenin with the transcription factor LEF-1

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Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Endocrine regulation of energy metabolism by the skeleton

Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997

Transcriptional control by the TGF‐β/Smad signaling system

Massagué, J., & Wotton, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1745 · Cited by 1,990

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789

Controlling TGF-beta signaling.

Massagué, J., & Chen, Y. (2000) · PubMed · Cited by 1,780

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5703 · Cited by 1,709

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591

Controlling TGF-β signalingPreprint

Massagué, J., & Chen, Y. (2000) · Genes & Development · doi:10.1101/gad.14.6.627 · Cited by 1,589

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

Lam, J., Takeshita, S., Barker, J. E., Kanagawa, O., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11176 · Cited by 1,440 · cited 2×

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C. J., Munemitsu, S. M., & Polakis, P. G. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,420

Competing interests: none declared.

Hirsch, L. (2006) · Cited by 1,396

NFAT Signaling

Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323

Dickkopf-1 is a master regulator of joint remodeling

Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,308

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · cited 2×

Signaling through focal adhesion kinase

Schlaepfer, D. D., Hauck, C. R., & Sieg, D. J. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00052-2 · Cited by 1,181

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J.-P., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,128

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086

Inactivation of the β-catenin gene by Wnt1-Cre -mediated deletion results in dramatic brain malformation and failure of craniofacial development

Brault, V., Moore, R., Kutsch, S., Ishibashi, M., Rowitch, D. H., McMahon, A. P., Sommer, L., Boussadia, O., & Kemler, R. (2001) · Development · doi:10.1242/dev.128.8.1253 · Cited by 1,076

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

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Regulation of osteoblast differentiation by transcription factors

Komori, T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20958 · Cited by 1,027

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G., Zhu, G., Tamada, K., et al. (2001) · Nature Immunology · doi:10.1038/85339 · Cited by 1,013

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

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Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

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Mechanotransduction and the functional response of bone to mechanical strain

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OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

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Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

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Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

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Sequential roles of Hedgehog and Wnt signaling in osteoblast development

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A Twist Code Determines the Onset of Osteoblast Differentiation

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Id Proteins Id1 and Id2 Selectively Inhibit DNA Binding by One Class of Helix-Loop-Helix Proteins

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Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogPreprint

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Interleukin-1

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Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

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B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo

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Mechanotransduction and strain amplification in osteocyte cell processes

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Functional and structural diversity of the human Dickkopf gene family

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A frizzled homolog functions in a vertebrate Wnt signaling pathway

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Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

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The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

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Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

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Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation

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Removal of Osteoclast Bone Resorption Products by Transcytosis

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wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

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Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

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BMP-2-induced Runx2 Expression Is Mediated by Dlx5, and TGF-β1 Opposes the BMP-2-induced Osteoblast Differentiation by Suppression of Dlx5 Expression

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Integration of FGF and TWIST in calvarial bone and suture development

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B7x: A widely expressed B7 family member that inhibits T cell activation

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BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2

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AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

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dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

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Trafficking of Matrix Collagens Through Bone-Resorbing Osteoclasts

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Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis

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