Cited by 614Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

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The cell biology of bone metabolism

Open access

Datta, H K, Ng, W F, Walker, J A, Tuck, S P, Varanasi, S S·2008·Journal of Clinical Pathology

DOI 10.1136/jcp.2007.048868

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Abstract

Contrary to the commonly held misconception, bone is a relatively dynamic organ that undergoes significant turnover as compared to other organs in the body. This review details how complex intercellular signalling, between the osteoprogenitor cells and mature osteoblasts, osteocytes and osteoclasts, regulates and balances activities of bone cells during remodelling and growth. Both systemic, as well as local autocrine and paracrine factors are discussed. A number of recent important advances in cell biology of bone have led to a new paradigm in understanding of the subject. In this regard, the interaction between the immune system and bone cells is of particular interest, leading to the emergence of a new discipline termed osteoimmunology. The role of lymphocytes and a number of key cytokines in the regulation of osteoclastogenesis and osteoblast function is critically examined. The intracellular signalling regulating key cellular pathways involved in cell differentiation and activity are outlined. The emerging evidence of osteocytes as mechanosensors as well as regulators of mineralisation is discussed.

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Authors: Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S.
Affiliations: Newcastle University (GB)
Leeds General Infirmary (GB)
James Cook University Hospital (GB)
Corresponding author: Datta, H K
ORCID: Datta, H K
Ng, W F
Tuck, S P
Venue: Journal of Clinical Pathology
Publisher: BMJ
Published: 2008-04-25
Volume: 61
Issue: 5
Pages: 577-587
ISSN: 0021-9746 (ISSN-L)
1472-4146
DOI: 10.1136/jcp.2007.048868
OpenAlex: W2031883266
Cited by: 614
References: 170
Citations by year: 2026: 13 · 2025: 42 · 2024: 61 · 2023: 45 · 2022: 67 · 2021: 53 · 2020: 38 · 2019: 37 · 2018: 35 · 2017: 21 · 2016: 21 · 2015: 14 · 2014: 24 · 2013: 36 · 2012: 22
FWCI: 11.42
Type: journal article
Language: en
Open access: green
doi.org
Locations: Journal of Clinical Pathology (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: bone metabolism, bone turnover, osteoblasts, osteocytes, osteoclasts, osteoprogenitor cells, bone remodeling, bone growth, intercellular communication, osteoimmunology, lymphocytes, cytokines, osteoclastogenesis, osteogenic differentiation, intracellular signaling, mechanosensing, bone mineralization
MeSH terms: Bone and Bones, Cell Differentiation, Energy Metabolism, Humans, Osteoblasts, Osteoclasts, Osteocytes, Signal Transduction, Bone Remodeling

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