Beyond and below the cortex: The contribution of striatal dysfunction to cognition and behaviour in neurodegeneration
Open accessAbstract
Investigations of cognitive and behavioural changes in neurodegeneration have been mostly focussed on how cortical changes can explain these symptoms. In the proposed review, we will argue that the striatum has been overlooked as a critical nexus in understanding the generation of such symptoms. Although the striatum is historically more associated with motor dysfunction, there is increasing evidence from functional neuroimaging studies in the healthy that striatal regions modulate behaviour and cognition. This should not be surprising, as the striatum has strong anatomical connections to many cortical regions including the frontal, temporal and insula lobes, as well as some subcortical regions (amygdala, hippocampus). To date, however, it is largely unclear to what extent striatal regions are affected in many neurodegenerative conditions-and if so, how striatal dysfunction can potentially influence cognition and behaviour. The proposed review will examine the existing evidence of striatal changes across selected neurodegenerative conditions (Parkinson's disease, progressive supranuclear palsy, Huntington's disease, motor neuron disease, frontotemporal dementia and Alzheimer's disease), and will document their link with the cognitive and behavioural impairments observed. Thus, by reviewing the varying degrees of cortical and striatal changes in these conditions, we can start outlining the contributions of the striatal nexus to cognitive and behavioural symptoms. In turn, this knowledge will inform future studies investigating corticostriatal networks and also diagnostic strategies, disease management and future therapeutics of neurodegenerative conditions.
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The frontal cortex and striatum have been previously shown to be susceptible to age-related neurodegenerative diseases.
“These brain regions have been previously shown to be susceptible to age-related neurodegenerative diseases.”
From Molecular and spatial signatures of mouse brain aging at single-cell resolution (2023) · cites this paper as [34]
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Flagged first, then by citations
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Cited by
Sorted by citations
Molecular and spatial signatures of mouse brain aging at single-cell resolution
Allen, W. E., Blosser, T. R., Sullivan, Z. A., Dulac, C., & Zhuang, X. (2023) · Cell · doi:10.1016/j.cell.2022.12.010 · Cited by 423 · see citing works
“These brain regions have been previously shown to be susceptible to age-related neurodegenerative diseases.(33,34) We sequenced 50,000 nuclei from two female animals at each age and performed unsupervised clustering analysis of the 80,000 cells that passed quality control (Figures S1A–S1F).”
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Self-citation
- Authors
- O'Callaghan, C., Bertoux, M., & Hornberger, M.
- Affiliations
- Sorbonne Université (FR)
- UNSW Sydney (AU)
- Corresponding author
- Hornberger, M.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2013-07-06
- Volume
- 85
- Issue
- 4
- Pages
- 371-378
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2168561180
- Cited by
- 131
- References
- 105
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 17 · 2020: 7 · 2019: 4 · 2018: 15 · 2017: 13 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Australian Research Council (DP110104202)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- striatal dysfunction, neurodegeneration, cognition, behavior, corticostriatal network, Parkinson's disease, progressive supranuclear palsy, Huntington's disease, motor neuron disease, frontotemporal dementia, Alzheimer's disease, cognitive impairment, behavioural symptoms
- MeSH terms
- Cerebral Cortex, Cognition Disorders, Corpus Striatum, Humans, Nerve Degeneration, Neural Pathways, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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