Cited by 1,134Neurological disorders and treatmentsParkinson's Disease Mechanisms and TreatmentsNeural and Behavioral Psychology Studies

Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease

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Redgrave, Peter, Rodriguez, Manuel, Smith, Yoland, Rodriguez-Oroz, Maria C., Lehericy, Stephane, Bergman, Hagai, Agid, Yves, DeLong, Mahlon R. +1 more·2010·Nature reviews. Neuroscience

Abstract

Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.

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  1. [164]Denny-Brown D The Basal Ganglia 1962 Oxford Univ. Press Oxford

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Authors
Redgrave, P., Rodriguez, M., Smith, Y., Rodriguez-Oroz, M. C., Lehericy, S., Bergman, H., Agid, Y., DeLong, M. R., & Obeso, J. A.
Affiliations
  • University of Sheffield (GB)
  • Emory University (US)
  • Hebrew University of Jerusalem (IL)
  • Institut du Cerveau (FR)
  • Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
Corresponding author
  • Redgrave, Peter
  • Obeso, Jose A.
Venue
Nature reviews. Neuroscience
Published
2010-10-14
Volume
11
Issue
11
Pages
760-772
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2056061278
Cited by
1,134
References
178
Citations by year
2026: 59 · 2025: 78 · 2024: 74 · 2023: 70 · 2022: 90 · 2021: 78 · 2020: 75 · 2019: 122 · 2018: 64 · 2017: 62 · 2016: 73 · 2015: 65 · 2014: 72 · 2013: 68 · 2012: 47
FWCI
6.08
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
Funders
  • Wellcome Trust (091409)
  • Universidad de Navarra
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
basal ganglia, Parkinson's disease, goal-directed behavior, habitual behavior, dopamine depletion, posterior putamen, action control
MeSH terms
Animals, Basal Ganglia, Goals, Habituation, Psychophysiologic, Humans, Models, Neurological, Nerve Net, Neural Pathways, Parkinson Disease

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