The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Oculomotor abnormalities parallel cerebellar histopathology in autism
Open accessAbstract
OBJECTIVE: To investigate cerebellar function in autism by measuring visually guided saccades. METHODS: A visually guided saccade task was performed by 46 high-functioning individuals with autism with and without delayed language acquisition, and 104 age and IQ matched healthy individuals. RESULTS: Individuals with autism had increased variability in saccade accuracy, and only those without delayed language development showed a mild saccadic hypometria. Neither autistic group showed a disturbance in peak saccade velocity or latency. CONCLUSIONS: The observed saccadic abnormalities suggest a functional disturbance in the cerebellar vermis or its output through the fastigial nuclei, consistent with reported cerebellar histopathology in autism. The pattern of mild hypometria and variable saccade accuracy is consistent with chronic rather than acute effects of cerebellar vermis lesions reported in clinical and non-human primate studies, as might be expected in a neurodevelopmental disorder. The different patterns of oculomotor deficits in individuals with autism with and without delayed language development suggest that pathophysiology at the level of the cerebellum may differ depending on an individual's history of language development.
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“Gaze linked to cerebellar function [23] is characteristically atypical in individuals with AD and the observation of subtle oculomotor alterations suggests abnormalities in cortico-cerebellar connectivity [24, 25].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [24]
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“Findings of reduced smooth pursuit velocity [202], hypometric saccades, and increased trial-to-trial variability of saccade amplitude [24] implicate vermal dysfunction in AD.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [24]
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“The ASD group was found to have increased variability in saccade accuracy, together with mild saccadic hypometria in those without delayed language development.”
From Vision in autism spectrum disorders (2009) · cites this paper as Takarae et al. (2004)
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Robertson, C. E., & Baron-Cohen, S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.112 · Cited by 1,157
Vision in autism spectrum disorders
Simmons, D. R., Robertson, A. E., McKay, L. S., Toal, E., McAleer, P., & Pollick, F. E. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.005 · Cited by 827
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
Motor Abilities in Autism: A Review Using a Computational Context
Gowen, E., & Hamilton, A. F. D. C. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1574-0 · Cited by 453
Eye-movements reveal attention to social information in autism spectrum disorder
Fletcher‐Watson, S., Leekam, S. R., Benson, V., Frank, M. C., & Findlay, J. M. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.07.016 · Cited by 386
Metadata
- Authors
- Takarae, Y.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Takarae, Y
- ORCID
- Takarae, Y
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2004-09-01
- Volume
- 75
- Issue
- 9
- Pages
- 1359-1361
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1739220
- OpenAlex
- W2073701500
- Cited by
- 110
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HD35469)
- National Institute of Mental Health (MH01433, K02MH001433)
- National Institute of Neurological Disorders and Stroke (NS33355)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035469, HD35469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- autism spectrum disorder, cerebellum, eye movement disorders, saccades, cerebellar vermis, language delay, cerebellar histopathology, neurodevelopmental disorders
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Cerebellum, Child, Female, Humans, Male, Reaction Time, Saccades, Task Performance and Analysis
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