Satiety dysfunction in Prader-Willi syndrome demonstrated by fMRI
Open accessAbstract
The neurobiology relating to the insatiable appetite observed in Prader-Willi syndrome (PWS) has not been fully characterised. Two functional magnetic resonance imaging (fMRI) scans were performed on each of three adults with PWS. The scans were carried out pre- and post-treatment with the antiepileptic topiramate, which had little effect on body weight and appetite in these subjects. Subjects fasted overnight and drank a 75 g dextrose solution prior to fMRI scans for measurement of brain activation levels during/after glucose ingestion. Following glucose administration, there was a significant delay in activation at the hypothalamus and other brain regions associated with satiety compared with previous data on obese volunteers. These regions include the insula, ventromedial prefrontal cortex, and nucleus accumbens. Individuals with PWS showed a mean latency of 24 min while in a previous study obese volunteers had shown a latency of 15 min and lean volunteers a latency of 10 min in the hypothalamus. Our results provide evidence towards a satiety dysfunction in the central nervous system of PWS patients.
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Shapira et al. showed that in patients with PWS there was a temporal delay in response to glucose ingestion in the resting-state activity of a distributed network implicated in the regulation of hunger and satiation, namely the hypothalamus, insular cortex, ventral basal ganglia, and ventromedial prefrontal cortex.
“Shapira and colleagues [682] showed that in patients with PWS that there was a temporal delay in response to glucose ingestion in the resting-state activity of a distributed network implicated in the regulation of hunger and satiation, namely the hypothalamus, insular cortex, ventral basal ganglia, and ventromedial prefrontal cortex.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [682]
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- Authors
- Shapira, N. A.
- Affiliations
- University of Florida (US)
- Corresponding author
- Shapira, N A
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2005-02-01
- Volume
- 76
- Issue
- 2
- Pages
- 260-262
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1739487
- OpenAlex
- W2124140144
- Cited by
- 130
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 10 · 2019: 8 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Florida Department of Health
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R21NS045518, NS45518)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Prader-Willi syndrome, appetite, hypothalamus, glucose ingestion, topiramate, obesity, insula, ventromedial prefrontal cortex, nucleus accumbens
- MeSH terms
- Adult, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Prader-Willi Syndrome, Satiety Response
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