Food Addiction and Cues in Prader-Willi Syndrome
Abstract
Obesity research has recognized that there are many factors contributing to this devastating disorder. Much debate has arisen among scientists to develop models that might be useful in understanding why obesity has become a major health problem and epidemic. However, much of the current debate has been fractious and causes of obesity have been attributed solely to behavior or fast food, personality issues, depression, addiction, or genetics. One of the neurohormonal and genetic causes has been found in Prader-Willi syndrome (PWS), which results in excessive, pathologic reinforcement of food. We have studied PWS to delineate the neurobiology so that environmental cue stimulation may be explained for PWS. Neuroimaging studies have shown that appetizing food and food cues are associated with appetite stimulation. Appetite control is poor in PWS, thus food cues play a major role in its regulation. Hence, PWS may be the genetic model of choice for obesity.
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Children with PWS show enhanced behavioral responses to food cues, which do not diminish after receiving a favorite food.
“Children with PWS show enhanced behavioral responses to food cues, which do not diminish after receiving a favorite food [675]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [675]
Genetic and other social and biological variables may contribute to vulnerability to obesity and weight gain.
“genetic and other social and biological variables may also contribute towards vulnerability to obesity and weight gain”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as von Deneen, Gold, & Liu, 2009
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- Authors
- von Deneen, K. M., Gold, M. S., & Liu, Y.
- Affiliations
- University of Florida (US)
- Venue
- Journal of Addiction Medicine
- Published
- 2009-03
- Volume
- 3
- Issue
- 1
- Pages
- 19-25
- ISSN
- 1932-0620 (ISSN-L)
- OpenAlex
- W1990290576
- Cited by
- 17
- References
- 75
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Addiction Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Prader-Willi syndrome, food addiction, food cues, obesity, appetite regulation, neurobiology of eating
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